Septin Assembly and Remodeling at the Cell Division Site During the Cell Cycle
The septin family of proteins can assemble into filaments that further organize into different higher order structures to perform a variety of different functions in different cell types and organisms. In the budding yeast Saccharomyces cerevisiae, the septins localize to the presumptive bud site as...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.793920/full |
| _version_ | 1818400632990597120 |
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| author | Joseph Marquardt Xi Chen Erfei Bi |
| author_facet | Joseph Marquardt Xi Chen Erfei Bi |
| author_sort | Joseph Marquardt |
| collection | DOAJ |
| description | The septin family of proteins can assemble into filaments that further organize into different higher order structures to perform a variety of different functions in different cell types and organisms. In the budding yeast Saccharomyces cerevisiae, the septins localize to the presumptive bud site as a cortical ring prior to bud emergence, expand into an hourglass at the bud neck (cell division site) during bud growth, and finally “split” into a double ring sandwiching the cell division machinery during cytokinesis. While much work has been done to understand the functions and molecular makeups of these structures, the mechanisms underlying the transitions from one structure to another have largely remained elusive. Recent studies involving advanced imaging and in vitro reconstitution have begun to reveal the vast complexity involved in the regulation of these structural transitions, which defines the focus of discussion in this mini-review. |
| first_indexed | 2024-12-14T07:39:40Z |
| format | Article |
| id | doaj.art-986d3eb47e6245cd825250ddeb7841a2 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-14T07:39:40Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-986d3eb47e6245cd825250ddeb7841a22022-12-21T23:11:04ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-11-01910.3389/fcell.2021.793920793920Septin Assembly and Remodeling at the Cell Division Site During the Cell CycleJoseph MarquardtXi ChenErfei BiThe septin family of proteins can assemble into filaments that further organize into different higher order structures to perform a variety of different functions in different cell types and organisms. In the budding yeast Saccharomyces cerevisiae, the septins localize to the presumptive bud site as a cortical ring prior to bud emergence, expand into an hourglass at the bud neck (cell division site) during bud growth, and finally “split” into a double ring sandwiching the cell division machinery during cytokinesis. While much work has been done to understand the functions and molecular makeups of these structures, the mechanisms underlying the transitions from one structure to another have largely remained elusive. Recent studies involving advanced imaging and in vitro reconstitution have begun to reveal the vast complexity involved in the regulation of these structural transitions, which defines the focus of discussion in this mini-review.https://www.frontiersin.org/articles/10.3389/fcell.2021.793920/fullseptinsseptin-associated proteinsRhoGEFanillinElm1Bud3 |
| spellingShingle | Joseph Marquardt Xi Chen Erfei Bi Septin Assembly and Remodeling at the Cell Division Site During the Cell Cycle Frontiers in Cell and Developmental Biology septins septin-associated proteins RhoGEF anillin Elm1 Bud3 |
| title | Septin Assembly and Remodeling at the Cell Division Site During the Cell Cycle |
| title_full | Septin Assembly and Remodeling at the Cell Division Site During the Cell Cycle |
| title_fullStr | Septin Assembly and Remodeling at the Cell Division Site During the Cell Cycle |
| title_full_unstemmed | Septin Assembly and Remodeling at the Cell Division Site During the Cell Cycle |
| title_short | Septin Assembly and Remodeling at the Cell Division Site During the Cell Cycle |
| title_sort | septin assembly and remodeling at the cell division site during the cell cycle |
| topic | septins septin-associated proteins RhoGEF anillin Elm1 Bud3 |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.793920/full |
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