Effectiveness of highly active antiretroviral therapy (HAART) used concomitantly with rifampicin in patients with tuberculosis and AIDS
This study evaluated the effectiveness of two HAART regimens concomitant to rifampicin based tuberculosis (TB) treatment. Patients with TB/HIV diagnosis followed at the TB program between June 2000 and March 2005 were prospectively evaluated. The different HAART regimens in antiretrovirals (ARV) tre...
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| Format: | Article |
| Language: | English |
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Elsevier
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| Series: | Brazilian Journal of Infectious Diseases |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500010&lng=en&tlng=en |
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| author | Flávia Marinho Sant'Anna Luciane Velasque Marli Jane Costa Carolina Arana Schmaltz Mariza Gonçalves Morgado Maria Cristina Lourenço Beatriz Grinsztejn Valéria Cavalcanti Rolla |
| author_facet | Flávia Marinho Sant'Anna Luciane Velasque Marli Jane Costa Carolina Arana Schmaltz Mariza Gonçalves Morgado Maria Cristina Lourenço Beatriz Grinsztejn Valéria Cavalcanti Rolla |
| author_sort | Flávia Marinho Sant'Anna |
| collection | DOAJ |
| description | This study evaluated the effectiveness of two HAART regimens concomitant to rifampicin based tuberculosis (TB) treatment. Patients with TB/HIV diagnosis followed at the TB program between June 2000 and March 2005 were prospectively evaluated. The different HAART regimens in antiretrovirals (ARV) treatment naïve and ARV experienced patients were compared. The effectiveness of HAART was defined as a VL <80 copies/mL from month 4 to month 10 after TB treatment. One hundred and forty-two patients were included. Among these, 68 (47%) were treatment naïve and 76 (53%) previously exposed. Odds ratio (OR) in naïve patients treated with efavirenz (EFV) based regimen (n=42) compared to ritonavir/saquinavir (RTV/SQV) based regimen (n=26) was 8.0 (CI=1.67-38.35, p=0.008). OR from ARV experienced patients treated with RTV/SQV based regimen compared to EFV was 3.08 (CI=0.65-14.6, p=0.15), although with no statistical significance. Better effectiveness and tolerability were observed in antiretrovirals treatment naïve patients using EFV based regimens. Although not statistically significant, a favorable virologic response and a better tolerability were observed in the ARV experienced patients group who received a RTV/SQV based regimen. |
| first_indexed | 2024-12-23T10:27:13Z |
| format | Article |
| id | doaj.art-986fb4a17937447da19897bb3c0181af |
| institution | Directory Open Access Journal |
| issn | 1678-4391 |
| language | English |
| last_indexed | 2024-12-23T10:27:13Z |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-986fb4a17937447da19897bb3c0181af2022-12-21T17:50:31ZengElsevierBrazilian Journal of Infectious Diseases1678-439113536236610.1590/S1413-86702009000500010S1413-86702009000500010Effectiveness of highly active antiretroviral therapy (HAART) used concomitantly with rifampicin in patients with tuberculosis and AIDSFlávia Marinho Sant'Anna0Luciane Velasque1Marli Jane Costa2Carolina Arana Schmaltz3Mariza Gonçalves Morgado4Maria Cristina Lourenço5Beatriz Grinsztejn6Valéria Cavalcanti Rolla7Fundação Oswaldo CruzFundação Oswaldo CruzFundação Oswaldo CruzFundação Oswaldo CruzFundação Oswaldo CruzFundação Oswaldo CruzFundação Oswaldo CruzFundação Oswaldo CruzThis study evaluated the effectiveness of two HAART regimens concomitant to rifampicin based tuberculosis (TB) treatment. Patients with TB/HIV diagnosis followed at the TB program between June 2000 and March 2005 were prospectively evaluated. The different HAART regimens in antiretrovirals (ARV) treatment naïve and ARV experienced patients were compared. The effectiveness of HAART was defined as a VL <80 copies/mL from month 4 to month 10 after TB treatment. One hundred and forty-two patients were included. Among these, 68 (47%) were treatment naïve and 76 (53%) previously exposed. Odds ratio (OR) in naïve patients treated with efavirenz (EFV) based regimen (n=42) compared to ritonavir/saquinavir (RTV/SQV) based regimen (n=26) was 8.0 (CI=1.67-38.35, p=0.008). OR from ARV experienced patients treated with RTV/SQV based regimen compared to EFV was 3.08 (CI=0.65-14.6, p=0.15), although with no statistical significance. Better effectiveness and tolerability were observed in antiretrovirals treatment naïve patients using EFV based regimens. Although not statistically significant, a favorable virologic response and a better tolerability were observed in the ARV experienced patients group who received a RTV/SQV based regimen.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500010&lng=en&tlng=enTuberculosisAIDSHAARTrifampicineffectiveness |
| spellingShingle | Flávia Marinho Sant'Anna Luciane Velasque Marli Jane Costa Carolina Arana Schmaltz Mariza Gonçalves Morgado Maria Cristina Lourenço Beatriz Grinsztejn Valéria Cavalcanti Rolla Effectiveness of highly active antiretroviral therapy (HAART) used concomitantly with rifampicin in patients with tuberculosis and AIDS Brazilian Journal of Infectious Diseases Tuberculosis AIDS HAART rifampicin effectiveness |
| title | Effectiveness of highly active antiretroviral therapy (HAART) used concomitantly with rifampicin in patients with tuberculosis and AIDS |
| title_full | Effectiveness of highly active antiretroviral therapy (HAART) used concomitantly with rifampicin in patients with tuberculosis and AIDS |
| title_fullStr | Effectiveness of highly active antiretroviral therapy (HAART) used concomitantly with rifampicin in patients with tuberculosis and AIDS |
| title_full_unstemmed | Effectiveness of highly active antiretroviral therapy (HAART) used concomitantly with rifampicin in patients with tuberculosis and AIDS |
| title_short | Effectiveness of highly active antiretroviral therapy (HAART) used concomitantly with rifampicin in patients with tuberculosis and AIDS |
| title_sort | effectiveness of highly active antiretroviral therapy haart used concomitantly with rifampicin in patients with tuberculosis and aids |
| topic | Tuberculosis AIDS HAART rifampicin effectiveness |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500010&lng=en&tlng=en |
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