Pulmonary function three to five months after hospital discharge for COVID-19: a single centre cohort study
Abstract Some COVID-19 survivors suffer from persistent pulmonary function impairment, but the extent and associated factors are unclear. This study aimed to characterize pulmonary function impairment three to five months after hospital discharge and the association with disease severity. Survivors...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-27879-8 |
| _version_ | 1797952564100071424 |
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| author | Tina Krueger Janelle van den Heuvel Vivian van Kampen-van den Boogaart Roel van Zeeland D. Jannet Mehagnoul-Schipper Dennis G. Barten Lieve Knarren Arno F. G. Maas Caroline E. Wyers Debbie Gach Annemie M. W. J. Schols Rosanne J. H. C. G. Beijers Joop P. van den Bergh Frits H. M. van Osch |
| author_facet | Tina Krueger Janelle van den Heuvel Vivian van Kampen-van den Boogaart Roel van Zeeland D. Jannet Mehagnoul-Schipper Dennis G. Barten Lieve Knarren Arno F. G. Maas Caroline E. Wyers Debbie Gach Annemie M. W. J. Schols Rosanne J. H. C. G. Beijers Joop P. van den Bergh Frits H. M. van Osch |
| author_sort | Tina Krueger |
| collection | DOAJ |
| description | Abstract Some COVID-19 survivors suffer from persistent pulmonary function impairment, but the extent and associated factors are unclear. This study aimed to characterize pulmonary function impairment three to five months after hospital discharge and the association with disease severity. Survivors of COVID-19 after hospitalization to the VieCuri Medical Centre between February and December 2020 were invited for follow-up, three to five months after discharge. Dynamic and static lung volumes, respiratory muscle strength and diffusion capacity were measured. The cohort comprised 257 patients after a moderate (n = 33), severe (n = 151) or critical (n = 73) COVID-19 infection with a median follow-up of 112 days (interquartile range 96–134 days). The main sequelae included reduced diffusion capacity (36%) and reduced maximal expiratory pressure (24%). Critically ill patients were more likely to have reduced diffusion capacity than moderate (OR 8.00, 95% CI 2.46–26.01) and severe cases (OR 3.74, 95% CI 1.88–7.44) and lower forced vital capacity (OR 3.29, 95% CI 1.20–9.06) compared to severe cases. Many COVID-19 survivors, especially after a critical disease course, showed pulmonary function sequelae, mainly DLCO impairments, three to five months after discharge. Monitoring is needed to investigate the persistence of these symptoms and the longer-term implications of the COVID-19 burden. |
| first_indexed | 2024-04-10T22:49:33Z |
| format | Article |
| id | doaj.art-98737c29297c47508c636234bbcaaf82 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-10T22:49:33Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-98737c29297c47508c636234bbcaaf822023-01-15T12:08:56ZengNature PortfolioScientific Reports2045-23222023-01-011311810.1038/s41598-023-27879-8Pulmonary function three to five months after hospital discharge for COVID-19: a single centre cohort studyTina Krueger0Janelle van den Heuvel1Vivian van Kampen-van den Boogaart2Roel van Zeeland3D. Jannet Mehagnoul-Schipper4Dennis G. Barten5Lieve Knarren6Arno F. G. Maas7Caroline E. Wyers8Debbie Gach9Annemie M. W. J. Schols10Rosanne J. H. C. G. Beijers11Joop P. van den Bergh12Frits H. M. van Osch13Department of Clinical Epidemiology, VieCuri Medical CentreDepartment of Clinical Epidemiology, VieCuri Medical CentreDepartment of Pulmonology, VieCuri Medical CentreDepartment of Pulmonology, VieCuri Medical CentreDepartment of Intensive Care, VieCuri Medical CentreDepartment of Emergency Medicine, VieCuri Medical CentreDepartment of Internal Medicine, VieCuri Medical CentreDepartment of Internal Medicine, VieCuri Medical CentreDepartment of Internal Medicine, VieCuri Medical CentreDepartment of Clinical Epidemiology, VieCuri Medical CentreDepartment of Respiratory Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+Department of Respiratory Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+Department of Internal Medicine, VieCuri Medical CentreDepartment of Clinical Epidemiology, VieCuri Medical CentreAbstract Some COVID-19 survivors suffer from persistent pulmonary function impairment, but the extent and associated factors are unclear. This study aimed to characterize pulmonary function impairment three to five months after hospital discharge and the association with disease severity. Survivors of COVID-19 after hospitalization to the VieCuri Medical Centre between February and December 2020 were invited for follow-up, three to five months after discharge. Dynamic and static lung volumes, respiratory muscle strength and diffusion capacity were measured. The cohort comprised 257 patients after a moderate (n = 33), severe (n = 151) or critical (n = 73) COVID-19 infection with a median follow-up of 112 days (interquartile range 96–134 days). The main sequelae included reduced diffusion capacity (36%) and reduced maximal expiratory pressure (24%). Critically ill patients were more likely to have reduced diffusion capacity than moderate (OR 8.00, 95% CI 2.46–26.01) and severe cases (OR 3.74, 95% CI 1.88–7.44) and lower forced vital capacity (OR 3.29, 95% CI 1.20–9.06) compared to severe cases. Many COVID-19 survivors, especially after a critical disease course, showed pulmonary function sequelae, mainly DLCO impairments, three to five months after discharge. Monitoring is needed to investigate the persistence of these symptoms and the longer-term implications of the COVID-19 burden.https://doi.org/10.1038/s41598-023-27879-8 |
| spellingShingle | Tina Krueger Janelle van den Heuvel Vivian van Kampen-van den Boogaart Roel van Zeeland D. Jannet Mehagnoul-Schipper Dennis G. Barten Lieve Knarren Arno F. G. Maas Caroline E. Wyers Debbie Gach Annemie M. W. J. Schols Rosanne J. H. C. G. Beijers Joop P. van den Bergh Frits H. M. van Osch Pulmonary function three to five months after hospital discharge for COVID-19: a single centre cohort study Scientific Reports |
| title | Pulmonary function three to five months after hospital discharge for COVID-19: a single centre cohort study |
| title_full | Pulmonary function three to five months after hospital discharge for COVID-19: a single centre cohort study |
| title_fullStr | Pulmonary function three to five months after hospital discharge for COVID-19: a single centre cohort study |
| title_full_unstemmed | Pulmonary function three to five months after hospital discharge for COVID-19: a single centre cohort study |
| title_short | Pulmonary function three to five months after hospital discharge for COVID-19: a single centre cohort study |
| title_sort | pulmonary function three to five months after hospital discharge for covid 19 a single centre cohort study |
| url | https://doi.org/10.1038/s41598-023-27879-8 |
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