AFM Imaging Reveals Multiple Conformational States of ADAMTS13

AFM Imaging Reveals Multiple Conformational States of ADAMTS13

Abstract Background ADAMTS13 (A disintegrin and metalloprotease with a thrombospondin type 1 motif 13) cleaves Von Willebrand factor (VWF) to regulate its size, thereby preventing aberrant platelet aggregation and thrombus. Deficiency of ADAMTS13 caused by either genetic mutations or by inhibitory a...

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Bibliographic Details
Main Authors: Shanshan Yu, Wang Liu, Jinhua Fang, Xiaozhong Shi, Jianhua Wu, Ying Fang, Jiangguo Lin
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Journal of Biological Engineering
Subjects:
ADAMTS13
atomic force microscopy
conformational states
pH
Online Access:http://link.springer.com/article/10.1186/s13036-018-0102-y

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