Cellulose Acetate-Based Electrospun Materials with a Variety of Biological Potentials: Antibacterial, Antifungal and Anticancer
Novel eco-friendly fibrous materials with complex activities from cellulose acetate and cellulose acetate/polyethylene glycol (CA,PEG) containing 5-chloro-8-hydroxyquinoline as a model drug were obtained by electrospinning. Several methods, including scanning electron microscopy, X-ray diffraction a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/13/10/1631 |
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| author | Mariya Spasova Nevena Manolova Iliya Rashkov Petya Tsekova Ani Georgieva Reneta Toshkova Nadya Markova |
| author_facet | Mariya Spasova Nevena Manolova Iliya Rashkov Petya Tsekova Ani Georgieva Reneta Toshkova Nadya Markova |
| author_sort | Mariya Spasova |
| collection | DOAJ |
| description | Novel eco-friendly fibrous materials with complex activities from cellulose acetate and cellulose acetate/polyethylene glycol (CA,PEG) containing 5-chloro-8-hydroxyquinoline as a model drug were obtained by electrospinning. Several methods, including scanning electron microscopy, X-ray diffraction analysis, ultraviolet-visible spectroscopy, water contact angle measurements, and mechanical tests, were utilized to characterize the obtained materials. The incorporation of PEG into the fibers facilitated the drug release. The amounts of the released drug from CA/5-Cl8Q and CA,PEG/5-Cl8Q were 78 ± 3.38% and 86 ± 3.02%, respectively (for 175 min). The antibacterial and antifungal activities of the obtained materials were studied. The measured zones of inhibition of CA/5-Cl8Q and CA,PEG/5-Cl8Q mats were 4.0 ± 0.18 and 4.5 ± 0.2 cm against <i>S. aureus</i> and around 4.0 ± 0.15 and 4.1 ± 0.22 cm against <i>E. coli</i>, respectively. The complete inhibition of the <i>C. albicans</i> growth was detected. The cytotoxicity of the obtained mats was tested toward HeLa cancer cells, SH-4 melanoma skin cells, and mouse BALB/c 3T3 fibroblasts as well. The CA/5-Cl8Q and CA,PEG/5-Cl8Q materials exhibited anticancer activity and low normal cell toxicity. Thus, the obtained fibrous materials can be suitable candidates for wound dressing applications and for application in local cancer treatment. |
| first_indexed | 2024-03-10T11:19:15Z |
| format | Article |
| id | doaj.art-987b73c7efcf4c65b5ad5c4562ce5bb4 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T11:19:15Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-987b73c7efcf4c65b5ad5c4562ce5bb42023-11-21T20:10:41ZengMDPI AGPolymers2073-43602021-05-011310163110.3390/polym13101631Cellulose Acetate-Based Electrospun Materials with a Variety of Biological Potentials: Antibacterial, Antifungal and AnticancerMariya Spasova0Nevena Manolova1Iliya Rashkov2Petya Tsekova3Ani Georgieva4Reneta Toshkova5Nadya Markova6Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Akad. G. Bonchev St, bl. 103A, BG-1113 Sofia, BulgariaLaboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Akad. G. Bonchev St, bl. 103A, BG-1113 Sofia, BulgariaLaboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Akad. G. Bonchev St, bl. 103A, BG-1113 Sofia, BulgariaLaboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Akad. G. Bonchev St, bl. 103A, BG-1113 Sofia, BulgariaInstitute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Akad. G. Bonchev St, bl. 25, BG-1113 Sofia, BulgariaInstitute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Akad. G. Bonchev St, bl. 25, BG-1113 Sofia, BulgariaInstitute of Microbiology, Bulgarian Academy of Sciences, Akad. G. Bonchev St, bl. 26, BG-1113 Sofia, BulgariaNovel eco-friendly fibrous materials with complex activities from cellulose acetate and cellulose acetate/polyethylene glycol (CA,PEG) containing 5-chloro-8-hydroxyquinoline as a model drug were obtained by electrospinning. Several methods, including scanning electron microscopy, X-ray diffraction analysis, ultraviolet-visible spectroscopy, water contact angle measurements, and mechanical tests, were utilized to characterize the obtained materials. The incorporation of PEG into the fibers facilitated the drug release. The amounts of the released drug from CA/5-Cl8Q and CA,PEG/5-Cl8Q were 78 ± 3.38% and 86 ± 3.02%, respectively (for 175 min). The antibacterial and antifungal activities of the obtained materials were studied. The measured zones of inhibition of CA/5-Cl8Q and CA,PEG/5-Cl8Q mats were 4.0 ± 0.18 and 4.5 ± 0.2 cm against <i>S. aureus</i> and around 4.0 ± 0.15 and 4.1 ± 0.22 cm against <i>E. coli</i>, respectively. The complete inhibition of the <i>C. albicans</i> growth was detected. The cytotoxicity of the obtained mats was tested toward HeLa cancer cells, SH-4 melanoma skin cells, and mouse BALB/c 3T3 fibroblasts as well. The CA/5-Cl8Q and CA,PEG/5-Cl8Q materials exhibited anticancer activity and low normal cell toxicity. Thus, the obtained fibrous materials can be suitable candidates for wound dressing applications and for application in local cancer treatment.https://www.mdpi.com/2073-4360/13/10/16315-chloro-8-hydroxyquinolinecellulose acetateelectrospinningantibacterialantifungal and anticancer activities |
| spellingShingle | Mariya Spasova Nevena Manolova Iliya Rashkov Petya Tsekova Ani Georgieva Reneta Toshkova Nadya Markova Cellulose Acetate-Based Electrospun Materials with a Variety of Biological Potentials: Antibacterial, Antifungal and Anticancer Polymers 5-chloro-8-hydroxyquinoline cellulose acetate electrospinning antibacterial antifungal and anticancer activities |
| title | Cellulose Acetate-Based Electrospun Materials with a Variety of Biological Potentials: Antibacterial, Antifungal and Anticancer |
| title_full | Cellulose Acetate-Based Electrospun Materials with a Variety of Biological Potentials: Antibacterial, Antifungal and Anticancer |
| title_fullStr | Cellulose Acetate-Based Electrospun Materials with a Variety of Biological Potentials: Antibacterial, Antifungal and Anticancer |
| title_full_unstemmed | Cellulose Acetate-Based Electrospun Materials with a Variety of Biological Potentials: Antibacterial, Antifungal and Anticancer |
| title_short | Cellulose Acetate-Based Electrospun Materials with a Variety of Biological Potentials: Antibacterial, Antifungal and Anticancer |
| title_sort | cellulose acetate based electrospun materials with a variety of biological potentials antibacterial antifungal and anticancer |
| topic | 5-chloro-8-hydroxyquinoline cellulose acetate electrospinning antibacterial antifungal and anticancer activities |
| url | https://www.mdpi.com/2073-4360/13/10/1631 |
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