Giant parathyroid adenoma presenting with multiple pathologic fractures: A case report
Key Clinical Message Hyperparathyroidism is a common endocrine disorder, which must be suspected in patients presenting with fatigue, history of pathologic fracture and the diagnosis can be confirmed by elevated calcium and PTH levels, and the preferred treatment option. Abstract Primary hyperparath...
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| Format: | Article |
| Language: | English |
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Wiley
2023-06-01
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| Series: | Clinical Case Reports |
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| Online Access: | https://doi.org/10.1002/ccr3.7474 |
| _version_ | 1797791672233361408 |
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| author | Hassan Abshirini Mahsa Heidari Ali Fahimi Parastoo Ghorbani Erfan Ghadirzadeh Sasan Shafiei |
| author_facet | Hassan Abshirini Mahsa Heidari Ali Fahimi Parastoo Ghorbani Erfan Ghadirzadeh Sasan Shafiei |
| author_sort | Hassan Abshirini |
| collection | DOAJ |
| description | Key Clinical Message Hyperparathyroidism is a common endocrine disorder, which must be suspected in patients presenting with fatigue, history of pathologic fracture and the diagnosis can be confirmed by elevated calcium and PTH levels, and the preferred treatment option. Abstract Primary hyperparathyroidism (PHPT), a common endocrine condition, with elevated parathormone production causes increased blood calcium levels. Parathyroid adenomas cause the majority of PHPT cases. Significant hypercalcemia can result from giant parathyroid adenomas. A calcium crisis may not always arise in these individuals, despite enormous parathyroid adenomas and high parathyroid hormone levels, and the masses may first be mistaken for a thyroid mass. In this article, we discuss the case of a 57‐year‐old Iranian man who suffered from PHPT due to a massive parathyroid adenoma and had a history of extreme fatigue and several traumatic fractures. As specialists, we should have a strong clinical suspicion of giant parathyroid adenoma as reason of hyperparathyroidism. In patients with multiple bone problems such as pain and multiple pathological fractures and elevated levels of calcium and PTH, the diagnosis of GPA must be considered and their preferred treatment is surgery. |
| first_indexed | 2024-03-13T02:23:14Z |
| format | Article |
| id | doaj.art-987bdc9ecfd142abb186fd561e38e785 |
| institution | Directory Open Access Journal |
| issn | 2050-0904 |
| language | English |
| last_indexed | 2024-03-13T02:23:14Z |
| publishDate | 2023-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj.art-987bdc9ecfd142abb186fd561e38e7852023-06-30T07:34:08ZengWileyClinical Case Reports2050-09042023-06-01116n/an/a10.1002/ccr3.7474Giant parathyroid adenoma presenting with multiple pathologic fractures: A case reportHassan Abshirini0Mahsa Heidari1Ali Fahimi2Parastoo Ghorbani3Erfan Ghadirzadeh4Sasan Shafiei5Department of Otorhinolaryngology, Imam Khomeini Hospital Jundishapur University of Medical Sciences Ahvaz IranDepartment of Otorhinolaryngology, Boalisina Hospital Mazandaran University of Medical Science Sari IranDepartment of Otorhinolaryngology, Boalisina Hospital Mazandaran University of Medical Science Sari IranDepartment of Internal Medicine, Faculty of Medicine Mazandaran University of Medical Science Sari IranGastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases Shahid Beheshti University of Medical Sciences Tehran IranSkull Base Research Center, Loghman Hakim Hospital Shahid Beheshti University of Medical Sciences Tehran IranKey Clinical Message Hyperparathyroidism is a common endocrine disorder, which must be suspected in patients presenting with fatigue, history of pathologic fracture and the diagnosis can be confirmed by elevated calcium and PTH levels, and the preferred treatment option. Abstract Primary hyperparathyroidism (PHPT), a common endocrine condition, with elevated parathormone production causes increased blood calcium levels. Parathyroid adenomas cause the majority of PHPT cases. Significant hypercalcemia can result from giant parathyroid adenomas. A calcium crisis may not always arise in these individuals, despite enormous parathyroid adenomas and high parathyroid hormone levels, and the masses may first be mistaken for a thyroid mass. In this article, we discuss the case of a 57‐year‐old Iranian man who suffered from PHPT due to a massive parathyroid adenoma and had a history of extreme fatigue and several traumatic fractures. As specialists, we should have a strong clinical suspicion of giant parathyroid adenoma as reason of hyperparathyroidism. In patients with multiple bone problems such as pain and multiple pathological fractures and elevated levels of calcium and PTH, the diagnosis of GPA must be considered and their preferred treatment is surgery.https://doi.org/10.1002/ccr3.7474hypercalcemiaparathyroid adenomaparathyroid hormoneprimary hyperparathyroidism |
| spellingShingle | Hassan Abshirini Mahsa Heidari Ali Fahimi Parastoo Ghorbani Erfan Ghadirzadeh Sasan Shafiei Giant parathyroid adenoma presenting with multiple pathologic fractures: A case report Clinical Case Reports hypercalcemia parathyroid adenoma parathyroid hormone primary hyperparathyroidism |
| title | Giant parathyroid adenoma presenting with multiple pathologic fractures: A case report |
| title_full | Giant parathyroid adenoma presenting with multiple pathologic fractures: A case report |
| title_fullStr | Giant parathyroid adenoma presenting with multiple pathologic fractures: A case report |
| title_full_unstemmed | Giant parathyroid adenoma presenting with multiple pathologic fractures: A case report |
| title_short | Giant parathyroid adenoma presenting with multiple pathologic fractures: A case report |
| title_sort | giant parathyroid adenoma presenting with multiple pathologic fractures a case report |
| topic | hypercalcemia parathyroid adenoma parathyroid hormone primary hyperparathyroidism |
| url | https://doi.org/10.1002/ccr3.7474 |
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