Evaluation of qualitative and quantitative data of Y-90 imaging in SPECT/CT and PET/CT phantom studies.
<h4>Introduction</h4>We aimed to assess the feasibility of SPECT and PET Y-90 imaging, and to compare these modalities by visualizing hot and cold foci in phantoms for varying isotope concentrations.<h4>Materials and methods</h4>The data was acquired from the Jaszczak and NEM...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0246848 |
| _version_ | 1819003503639527424 |
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| author | Agata Kubik Anna Budzyńska Krzysztof Kacperski Maciej Maciak Michał Kuć Piotr Piasecki Maciej Wiliński Marcin Konior Mirosław Dziuk Edward Iller |
| author_facet | Agata Kubik Anna Budzyńska Krzysztof Kacperski Maciej Maciak Michał Kuć Piotr Piasecki Maciej Wiliński Marcin Konior Mirosław Dziuk Edward Iller |
| author_sort | Agata Kubik |
| collection | DOAJ |
| description | <h4>Introduction</h4>We aimed to assess the feasibility of SPECT and PET Y-90 imaging, and to compare these modalities by visualizing hot and cold foci in phantoms for varying isotope concentrations.<h4>Materials and methods</h4>The data was acquired from the Jaszczak and NEMA phantoms. In the Jaszczak phantom Y-90 concentrations of 0.1 MBq/ml and 0.2 MBq/ml were used, while higher concentrations, up to 1.0 MBq/ml, were simulated by acquisition time extension with respect to the standard clinical protocol of 30 sec/projection for SPECT and 30 min/bed position for PET imaging. For NEMA phantom, the hot foci had concentrations of about 4 MB/ml and the background 0.1 or 0.0 MBq/ml. All of the acquired data was analysed both qualitatively and quantitatively. Qualitative assessment was conducted by six observers asked to identify the number of visible cold or hot foci. Inter-observer agreement was assessed. Quantitative analysis included calculations of contrast and contrast-to-noise ratio (CNR), and comparisons with the qualitative results.<h4>Results</h4>For SPECT data up to two cold foci were discernible, while for PET four foci were visible. We have shown that CNR (with Rose criterion) is a good measure of foci visibility for both modalities. We also found good concordance of qualitative results for the Jaszczak phantom studies between the observers (corresponding Krippendorf's alpha coefficients of 0.76 to 0.84). In the NEMA phantom without background activity all foci were visible in SPECT/CT images. With isotope in the background, 5 of 6 spheres were discernible (CNR of 3.0 for the smallest foci). For PET studies all hot spheres were visible, regardless of the background activity.<h4>Conclusions</h4>PET Y-90 imaging provided better results than Bremsstrahlung based SPECT imaging. This indicates that PET/CT might become the method of choice in Y-90 post radioembolization imaging for visualisation of both necrotic and hot lesions in the liver. |
| first_indexed | 2024-12-20T23:22:02Z |
| format | Article |
| id | doaj.art-987c0e1818394b47acf615ab8d5aff73 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T23:22:02Z |
| publishDate | 2021-01-01 |
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| spelling | doaj.art-987c0e1818394b47acf615ab8d5aff732022-12-21T19:23:29ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01162e024684810.1371/journal.pone.0246848Evaluation of qualitative and quantitative data of Y-90 imaging in SPECT/CT and PET/CT phantom studies.Agata KubikAnna BudzyńskaKrzysztof KacperskiMaciej MaciakMichał KućPiotr PiaseckiMaciej WilińskiMarcin KoniorMirosław DziukEdward Iller<h4>Introduction</h4>We aimed to assess the feasibility of SPECT and PET Y-90 imaging, and to compare these modalities by visualizing hot and cold foci in phantoms for varying isotope concentrations.<h4>Materials and methods</h4>The data was acquired from the Jaszczak and NEMA phantoms. In the Jaszczak phantom Y-90 concentrations of 0.1 MBq/ml and 0.2 MBq/ml were used, while higher concentrations, up to 1.0 MBq/ml, were simulated by acquisition time extension with respect to the standard clinical protocol of 30 sec/projection for SPECT and 30 min/bed position for PET imaging. For NEMA phantom, the hot foci had concentrations of about 4 MB/ml and the background 0.1 or 0.0 MBq/ml. All of the acquired data was analysed both qualitatively and quantitatively. Qualitative assessment was conducted by six observers asked to identify the number of visible cold or hot foci. Inter-observer agreement was assessed. Quantitative analysis included calculations of contrast and contrast-to-noise ratio (CNR), and comparisons with the qualitative results.<h4>Results</h4>For SPECT data up to two cold foci were discernible, while for PET four foci were visible. We have shown that CNR (with Rose criterion) is a good measure of foci visibility for both modalities. We also found good concordance of qualitative results for the Jaszczak phantom studies between the observers (corresponding Krippendorf's alpha coefficients of 0.76 to 0.84). In the NEMA phantom without background activity all foci were visible in SPECT/CT images. With isotope in the background, 5 of 6 spheres were discernible (CNR of 3.0 for the smallest foci). For PET studies all hot spheres were visible, regardless of the background activity.<h4>Conclusions</h4>PET Y-90 imaging provided better results than Bremsstrahlung based SPECT imaging. This indicates that PET/CT might become the method of choice in Y-90 post radioembolization imaging for visualisation of both necrotic and hot lesions in the liver.https://doi.org/10.1371/journal.pone.0246848 |
| spellingShingle | Agata Kubik Anna Budzyńska Krzysztof Kacperski Maciej Maciak Michał Kuć Piotr Piasecki Maciej Wiliński Marcin Konior Mirosław Dziuk Edward Iller Evaluation of qualitative and quantitative data of Y-90 imaging in SPECT/CT and PET/CT phantom studies. PLoS ONE |
| title | Evaluation of qualitative and quantitative data of Y-90 imaging in SPECT/CT and PET/CT phantom studies. |
| title_full | Evaluation of qualitative and quantitative data of Y-90 imaging in SPECT/CT and PET/CT phantom studies. |
| title_fullStr | Evaluation of qualitative and quantitative data of Y-90 imaging in SPECT/CT and PET/CT phantom studies. |
| title_full_unstemmed | Evaluation of qualitative and quantitative data of Y-90 imaging in SPECT/CT and PET/CT phantom studies. |
| title_short | Evaluation of qualitative and quantitative data of Y-90 imaging in SPECT/CT and PET/CT phantom studies. |
| title_sort | evaluation of qualitative and quantitative data of y 90 imaging in spect ct and pet ct phantom studies |
| url | https://doi.org/10.1371/journal.pone.0246848 |
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