Trabeculopuncture as a predictive test of distal outflow resistance in canal-based surgery
Abstract We investigated whether trabeculopuncture (TP) could detect distal outflow resistance to predict the outcome of canal-based glaucoma surgery such as ab interno trabeculectomy (AIT). These procedures have a high utilization in open angle glaucoma, but fail in eyes with an unidentified distal...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-13990-9 |
| _version_ | 1811334272559087616 |
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| author | R. Verma-Fuehring M. Dakroub H. Han J. Hillenkamp N. A. Loewen |
| author_facet | R. Verma-Fuehring M. Dakroub H. Han J. Hillenkamp N. A. Loewen |
| author_sort | R. Verma-Fuehring |
| collection | DOAJ |
| description | Abstract We investigated whether trabeculopuncture (TP) could detect distal outflow resistance to predict the outcome of canal-based glaucoma surgery such as ab interno trabeculectomy (AIT). These procedures have a high utilization in open angle glaucoma, but fail in eyes with an unidentified distal outflow resistance. We assigned 81 porcine eyes to two groups: trial (n = 42) and control (n = 39). At 24 h, four YAG-laser trabeculopunctures were placed nasally, followed by a 180° AIT at the same site at 48 h. The proportion of TP responders between both AIT groups was compared. Histology and outflow canalograms were determined. Both post-TP and post-AIT IOPs were lower than baseline IOP (p = 0.015 and p < 0.01, respectively). The success rates of TP and AIT were 69% and 85.7%, respectively. Sensitivity and specificity values of TP as predictive test for AIT success were 77.7% and 83.3%, respectively. The positive and negative predictive values were 96.6% and 38.5%, respectively. We conclude that a 10% reduction in IOP after TP can be used as a predictor for the success (> 20% IOP decrease) of 180° AIT in porcine eyes. |
| first_indexed | 2024-04-13T17:06:13Z |
| format | Article |
| id | doaj.art-987e5a3738544714a21265f10a45d957 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T17:06:13Z |
| publishDate | 2022-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-987e5a3738544714a21265f10a45d9572022-12-22T02:38:28ZengNature PortfolioScientific Reports2045-23222022-06-011211810.1038/s41598-022-13990-9Trabeculopuncture as a predictive test of distal outflow resistance in canal-based surgeryR. Verma-Fuehring0M. Dakroub1H. Han2J. Hillenkamp3N. A. Loewen4Department of Ophthalmology, University of WürzburgDepartment of Ophthalmology, University of WürzburgDepartment of Ophthalmology, University of WürzburgDepartment of Ophthalmology, University of WürzburgDepartment of Ophthalmology, University of WürzburgAbstract We investigated whether trabeculopuncture (TP) could detect distal outflow resistance to predict the outcome of canal-based glaucoma surgery such as ab interno trabeculectomy (AIT). These procedures have a high utilization in open angle glaucoma, but fail in eyes with an unidentified distal outflow resistance. We assigned 81 porcine eyes to two groups: trial (n = 42) and control (n = 39). At 24 h, four YAG-laser trabeculopunctures were placed nasally, followed by a 180° AIT at the same site at 48 h. The proportion of TP responders between both AIT groups was compared. Histology and outflow canalograms were determined. Both post-TP and post-AIT IOPs were lower than baseline IOP (p = 0.015 and p < 0.01, respectively). The success rates of TP and AIT were 69% and 85.7%, respectively. Sensitivity and specificity values of TP as predictive test for AIT success were 77.7% and 83.3%, respectively. The positive and negative predictive values were 96.6% and 38.5%, respectively. We conclude that a 10% reduction in IOP after TP can be used as a predictor for the success (> 20% IOP decrease) of 180° AIT in porcine eyes.https://doi.org/10.1038/s41598-022-13990-9 |
| spellingShingle | R. Verma-Fuehring M. Dakroub H. Han J. Hillenkamp N. A. Loewen Trabeculopuncture as a predictive test of distal outflow resistance in canal-based surgery Scientific Reports |
| title | Trabeculopuncture as a predictive test of distal outflow resistance in canal-based surgery |
| title_full | Trabeculopuncture as a predictive test of distal outflow resistance in canal-based surgery |
| title_fullStr | Trabeculopuncture as a predictive test of distal outflow resistance in canal-based surgery |
| title_full_unstemmed | Trabeculopuncture as a predictive test of distal outflow resistance in canal-based surgery |
| title_short | Trabeculopuncture as a predictive test of distal outflow resistance in canal-based surgery |
| title_sort | trabeculopuncture as a predictive test of distal outflow resistance in canal based surgery |
| url | https://doi.org/10.1038/s41598-022-13990-9 |
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