Retracted: Effects of cardiac resynchronization therapy in patients with inotrope‐dependent class IV end‐stage heart failure
Abstract Background Cardiac resynchronization therapy (CRT) has been widely used for the treatment of refractory heart failure (HF). However, the efficacy of CRT is not well established in class IV HF patients on inotropic support. Methods Twenty‐six patients (age 55±18 years, 73% men) with inotrope...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-12-01
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| Series: | Journal of Arrhythmia |
| Subjects: | |
| Online Access: | https://doi.org/10.1016/j.joa.2013.05.007 |
| _version_ | 1818319762910871552 |
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| author | Ikutaro Nakajima Takashi Noda Hideaki Kanzaki Kohei Ishibashi Koji Miyamoto Yuko Yamada Hideo Okamura Kazuhiro Satomi Takeshi Aiba Shiro Kamakura Toshihisa Anzai Masaharu Ishihara Satoshi Yasuda Hisao Ogawa Wataru Shimizu |
| author_facet | Ikutaro Nakajima Takashi Noda Hideaki Kanzaki Kohei Ishibashi Koji Miyamoto Yuko Yamada Hideo Okamura Kazuhiro Satomi Takeshi Aiba Shiro Kamakura Toshihisa Anzai Masaharu Ishihara Satoshi Yasuda Hisao Ogawa Wataru Shimizu |
| author_sort | Ikutaro Nakajima |
| collection | DOAJ |
| description | Abstract Background Cardiac resynchronization therapy (CRT) has been widely used for the treatment of refractory heart failure (HF). However, the efficacy of CRT is not well established in class IV HF patients on inotropic support. Methods Twenty‐six patients (age 55±18 years, 73% men) with inotrope‐dependent HF were reviewed to evaluate the effectiveness of CRT in class IV HF patients on inotropic support. Results Intravenous inotropic therapy was administered for 72±56 days before CRT and consisted of dobutamine (n=24; 3.0±1.2 μg kg−1 min−1), dopamine (n=2; 4.5±2.1 μg kg−1 min−1), and/or milrinone (n=16; 0.12±0.09 μg kg−1 min−1). CRT did not produce significant reverse remodeling in eligible patients (left ventricular ejection fraction 23±7% to 25±9%; p=0.23, left ventricular end‐diastolic diameter 70±9 mm to 68±9 mm; p=0.14). After CRT device implantation, 13 (50%) patients experienced 1 or more episodes of ventricular tachyarrhythmia or sudden cardiac death. Twenty (77%) patients survived to hospital discharge with weaning from inotropic support (70±70 days after CRT implantation). The 1‐year survival rate was 81%. However, data from long‐term follow‐up showed that 68% of the study patients who attained survival discharge had an HF hospitalization event within the follow‐up period. Conclusion CRT did not result in significant reverse remodeling in patients with inotrope‐dependent class IV end‐stage HF. However, it contributed to dramatically improve the cardiovascular outcomes at least in the short‐term period in some patients. |
| first_indexed | 2024-12-13T10:14:16Z |
| format | Article |
| id | doaj.art-988020c2174e4cffadb161e04ae43818 |
| institution | Directory Open Access Journal |
| issn | 1880-4276 1883-2148 |
| language | English |
| last_indexed | 2024-12-13T10:14:16Z |
| publishDate | 2013-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Arrhythmia |
| spelling | doaj.art-988020c2174e4cffadb161e04ae438182022-12-21T23:51:21ZengWileyJournal of Arrhythmia1880-42761883-21482013-12-0129634234610.1016/j.joa.2013.05.007Retracted: Effects of cardiac resynchronization therapy in patients with inotrope‐dependent class IV end‐stage heart failureIkutaro Nakajima0Takashi Noda1Hideaki Kanzaki2Kohei Ishibashi3Koji Miyamoto4Yuko Yamada5Hideo Okamura6Kazuhiro Satomi7Takeshi Aiba8Shiro Kamakura9Toshihisa Anzai10Masaharu Ishihara11Satoshi Yasuda12Hisao Ogawa13Wataru Shimizu14Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, JapanDepartment of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, JapanDepartment of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, JapanDepartment of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, JapanDepartment of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, JapanDepartment of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, JapanDepartment of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, JapanDepartment of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, JapanDepartment of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, JapanDepartment of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, JapanDepartment of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, JapanDepartment of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, JapanDepartment of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, JapanDepartment of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, JapanDepartment of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, JapanAbstract Background Cardiac resynchronization therapy (CRT) has been widely used for the treatment of refractory heart failure (HF). However, the efficacy of CRT is not well established in class IV HF patients on inotropic support. Methods Twenty‐six patients (age 55±18 years, 73% men) with inotrope‐dependent HF were reviewed to evaluate the effectiveness of CRT in class IV HF patients on inotropic support. Results Intravenous inotropic therapy was administered for 72±56 days before CRT and consisted of dobutamine (n=24; 3.0±1.2 μg kg−1 min−1), dopamine (n=2; 4.5±2.1 μg kg−1 min−1), and/or milrinone (n=16; 0.12±0.09 μg kg−1 min−1). CRT did not produce significant reverse remodeling in eligible patients (left ventricular ejection fraction 23±7% to 25±9%; p=0.23, left ventricular end‐diastolic diameter 70±9 mm to 68±9 mm; p=0.14). After CRT device implantation, 13 (50%) patients experienced 1 or more episodes of ventricular tachyarrhythmia or sudden cardiac death. Twenty (77%) patients survived to hospital discharge with weaning from inotropic support (70±70 days after CRT implantation). The 1‐year survival rate was 81%. However, data from long‐term follow‐up showed that 68% of the study patients who attained survival discharge had an HF hospitalization event within the follow‐up period. Conclusion CRT did not result in significant reverse remodeling in patients with inotrope‐dependent class IV end‐stage HF. However, it contributed to dramatically improve the cardiovascular outcomes at least in the short‐term period in some patients.https://doi.org/10.1016/j.joa.2013.05.007Cardiac resynchronization therapyInotrope‐dependent heart failureSurvival |
| spellingShingle | Ikutaro Nakajima Takashi Noda Hideaki Kanzaki Kohei Ishibashi Koji Miyamoto Yuko Yamada Hideo Okamura Kazuhiro Satomi Takeshi Aiba Shiro Kamakura Toshihisa Anzai Masaharu Ishihara Satoshi Yasuda Hisao Ogawa Wataru Shimizu Retracted: Effects of cardiac resynchronization therapy in patients with inotrope‐dependent class IV end‐stage heart failure Journal of Arrhythmia Cardiac resynchronization therapy Inotrope‐dependent heart failure Survival |
| title | Retracted: Effects of cardiac resynchronization therapy in patients with inotrope‐dependent class IV end‐stage heart failure |
| title_full | Retracted: Effects of cardiac resynchronization therapy in patients with inotrope‐dependent class IV end‐stage heart failure |
| title_fullStr | Retracted: Effects of cardiac resynchronization therapy in patients with inotrope‐dependent class IV end‐stage heart failure |
| title_full_unstemmed | Retracted: Effects of cardiac resynchronization therapy in patients with inotrope‐dependent class IV end‐stage heart failure |
| title_short | Retracted: Effects of cardiac resynchronization therapy in patients with inotrope‐dependent class IV end‐stage heart failure |
| title_sort | retracted effects of cardiac resynchronization therapy in patients with inotrope dependent class iv end stage heart failure |
| topic | Cardiac resynchronization therapy Inotrope‐dependent heart failure Survival |
| url | https://doi.org/10.1016/j.joa.2013.05.007 |
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