Safety and efficacy of Sofosbuvir therapy in chronic hepatitis C patients of Peshawar, Khyber Pakhtunkhwa, Pakistan
This study is designed to monitor the rapid virological response (RVR) for 8 weeks and sustained virological response (SVR) for 12 weeks during Sofosbuvir therapy in chronic hepatitis C patients in Peshawar, KPK, Pakistan. A total of 162 hepatitis C positive patients were enrolled in this study. A...
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| Format: | Article |
| Language: | English |
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Prince of Songkla University
2022-06-01
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| Series: | Songklanakarin Journal of Science and Technology (SJST) |
| Subjects: | |
| Online Access: | https://sjst.psu.ac.th/journal/44-3/13.pdf |
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| author | Muhammad Jawad Sobia Attaullah Sanaullah khan Faheem Ullah Muhammad Zahid Faisal Saeed Ayesha Rizwan Abdul Wahab |
| author_facet | Muhammad Jawad Sobia Attaullah Sanaullah khan Faheem Ullah Muhammad Zahid Faisal Saeed Ayesha Rizwan Abdul Wahab |
| author_sort | Muhammad Jawad |
| collection | DOAJ |
| description | This study is designed to monitor the rapid virological response (RVR) for 8 weeks and sustained virological response
(SVR) for 12 weeks during Sofosbuvir therapy in chronic hepatitis C patients in Peshawar, KPK, Pakistan. A total of 162
hepatitis C positive patients were enrolled in this study. After RNA isolation, Quantitative PCR was done to get viral load, and
Ohn et al., 1997 protocol were used for hepatitis virus different genotypes. Statistical analysis was performed using SPSS. A
Sample t-test was applied to compare gender and age. Chi Square test was applied to compare the RVR and SVR. In total 162
positive hepatitis C patients, 90 were male and 72 were female. High rate 153(94%) of RVR and 158(97%) SVR were achieved
during 8 and 12 weeks of sofosbuvir therapy. High SVR and RVR were achieved in the <30 and 31-40 age groups. High EVR
125(99%) by genotype 3 were achieved at 8 weeks of therapy and high SVR 126(100%) by genotype 3 and 28(93%) by genotype
1 were achieved at 12 weeks of sofosbuvir therapy. The current study reveals that high RVR and SVR rates were obtained by
shortening the SOF therapy's treatment time up to 8 and 12 weeks. We got a 98.7% response rate at the end of the treatment. |
| first_indexed | 2024-04-09T18:37:39Z |
| format | Article |
| id | doaj.art-9881283fc23549b58719145ce795d021 |
| institution | Directory Open Access Journal |
| issn | 0125-3395 |
| language | English |
| last_indexed | 2024-04-09T18:37:39Z |
| publishDate | 2022-06-01 |
| publisher | Prince of Songkla University |
| record_format | Article |
| series | Songklanakarin Journal of Science and Technology (SJST) |
| spelling | doaj.art-9881283fc23549b58719145ce795d0212023-04-11T07:21:28ZengPrince of Songkla UniversitySongklanakarin Journal of Science and Technology (SJST)0125-33952022-06-0144368368910.14456/sjst-psu.2022.93Safety and efficacy of Sofosbuvir therapy in chronic hepatitis C patients of Peshawar, Khyber Pakhtunkhwa, PakistanMuhammad Jawad0Sobia Attaullah1Sanaullah khan2Faheem Ullah3Muhammad Zahid4Faisal Saeed5Ayesha Rizwan6Abdul Wahab7Department of Zoology, Islamia College Peshawar, Khyber Pakhtunkhwa, 25120 PakistanDepartment of Zoology, Islamia College Peshawar, Khyber Pakhtunkhwa, 25120 PakistanDepartment of Zoology, University of Peshawar, Khyber Pakhtunkhwa, 25120 PakistanPediatrics Medicine (FCPS-II), Medical Officer, Type “C” Hospital, Takht-e-Nasrati, Karak, Khyber Pakhtunkhwa, 25120 PakistanDepartment of Zoology, Islamia College Peshawar, Khyber Pakhtunkhwa, 25120 PakistanDepartment of Zoology, Islamia College Peshawar, Khyber Pakhtunkhwa, 25120 PakistanDepartment of Zoology, University of Peshawar, Khyber Pakhtunkhwa, 25120 PakistanDepartment of Zoology, Islamia College Peshawar, Khyber Pakhtunkhwa, 25120 PakistanThis study is designed to monitor the rapid virological response (RVR) for 8 weeks and sustained virological response (SVR) for 12 weeks during Sofosbuvir therapy in chronic hepatitis C patients in Peshawar, KPK, Pakistan. A total of 162 hepatitis C positive patients were enrolled in this study. After RNA isolation, Quantitative PCR was done to get viral load, and Ohn et al., 1997 protocol were used for hepatitis virus different genotypes. Statistical analysis was performed using SPSS. A Sample t-test was applied to compare gender and age. Chi Square test was applied to compare the RVR and SVR. In total 162 positive hepatitis C patients, 90 were male and 72 were female. High rate 153(94%) of RVR and 158(97%) SVR were achieved during 8 and 12 weeks of sofosbuvir therapy. High SVR and RVR were achieved in the <30 and 31-40 age groups. High EVR 125(99%) by genotype 3 were achieved at 8 weeks of therapy and high SVR 126(100%) by genotype 3 and 28(93%) by genotype 1 were achieved at 12 weeks of sofosbuvir therapy. The current study reveals that high RVR and SVR rates were obtained by shortening the SOF therapy's treatment time up to 8 and 12 weeks. We got a 98.7% response rate at the end of the treatment.https://sjst.psu.ac.th/journal/44-3/13.pdfefficacyhepatitis c virussofosbuvirtherapypeshawarpakistan |
| spellingShingle | Muhammad Jawad Sobia Attaullah Sanaullah khan Faheem Ullah Muhammad Zahid Faisal Saeed Ayesha Rizwan Abdul Wahab Safety and efficacy of Sofosbuvir therapy in chronic hepatitis C patients of Peshawar, Khyber Pakhtunkhwa, Pakistan Songklanakarin Journal of Science and Technology (SJST) efficacy hepatitis c virus sofosbuvir therapy peshawar pakistan |
| title | Safety and efficacy of Sofosbuvir therapy in chronic hepatitis C patients of Peshawar, Khyber Pakhtunkhwa, Pakistan |
| title_full | Safety and efficacy of Sofosbuvir therapy in chronic hepatitis C patients of Peshawar, Khyber Pakhtunkhwa, Pakistan |
| title_fullStr | Safety and efficacy of Sofosbuvir therapy in chronic hepatitis C patients of Peshawar, Khyber Pakhtunkhwa, Pakistan |
| title_full_unstemmed | Safety and efficacy of Sofosbuvir therapy in chronic hepatitis C patients of Peshawar, Khyber Pakhtunkhwa, Pakistan |
| title_short | Safety and efficacy of Sofosbuvir therapy in chronic hepatitis C patients of Peshawar, Khyber Pakhtunkhwa, Pakistan |
| title_sort | safety and efficacy of sofosbuvir therapy in chronic hepatitis c patients of peshawar khyber pakhtunkhwa pakistan |
| topic | efficacy hepatitis c virus sofosbuvir therapy peshawar pakistan |
| url | https://sjst.psu.ac.th/journal/44-3/13.pdf |
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