Pandemic flu in Russia: special features of a clinical course and the absence of early etiotropic therapy as a risk factor of severe forms of the disease

Pandemic flu in Russia: special features of a clinical course and the absence of early etiotropic therapy as a risk factor of severe forms of the disease

Aim. To assess efficacy and safety of ingavirin in the treatment of the flu caused by pandemic virus of flu A (H1N1) sw1 in hospitalized patients compared with oseltamivir. Material and methods. A population-based comparative multicenter trial included 194 patients with verified diagnosis of the flu...

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Bibliographic Details
Main Authors: Lyudmila Vasil'evna Kolobukhina, L N Merkulova, M Yu Shchelkanov, E I Burtseva, V V Lavrishcheva, E I Samokhvalov, S V Al'khovskiy, A G Prilipov, E S Proshina, S N Avdeev, O A Sutochnikova, M V Bazarova, E I Kelli, N D Tserukalova, I A Blank, O M Shestakova, O N Kolivashko, T V Arseneva, O E Ambrosi, A A Shul'dyakov, A F Popov, A I Simakova, N A Malyshev, A G Chuchalin, D K L'vov, L V Kolobukhina, M Yu Schelkanov, V V Lavrischeva, S V Alkhovsky, A A Shuldyakov, D K Lvov
Format: Article
Language:Russian
Published: "Consilium Medicum" Publishing house 2011-09-01
Series:Терапевтический архив
Subjects:
flu
pandemia
ingavirin
oseltamivir
treatment efficacy
Online Access:https://ter-arkhiv.ru/0040-3660/article/view/30921
Description
Summary:Aim. To assess efficacy and safety of ingavirin in the treatment of the flu caused by pandemic virus of flu A (H1N1) sw1 in hospitalized patients compared with oseltamivir. Material and methods. A population-based comparative multicenter trial included 194 patients with verified diagnosis of the flu aged 18-60 years with marked clinical symptoms, body temperature over 38 °C and duration of the disease 48 hours maximum. The patients were randomized into 2 groups: group 1 (n = 152) received ingavirin (90 mg once a day), group 2 received oseltamivir (n = 42) in a dose 150 mg twice a day. Duration of the course was 5 days. Results. Ingavirin and oseltamivir normalized body temperature within treatment hours 24-36 if therapy was initiated in the first disease hours 27.0±10.0 and 31.9±10.4. Mean duration of the fever for ingavirin was 35.1±14.5 hours, for oseltamivir - 26.3±13.0 hours (p < 0.817). The antiviral medicines significantly reduced duration of intoxication (head ache, weakness), catarrhal symptoms (cough, tracheitis, rhinitis), rate of complication vs patients untreated with antivirus drugs (n = 30). Conclusion. The results of the treatment show safety and efficacy of ingavirin in uncomplicated flu caused by pandemic virus of flu A (H1N1) sw1 in inpatients. Early etiotropic therapy is a basic treatment policy able to reduce the number of severe complications and lethality.
ISSN:0040-3660
2309-5342

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