Short course palliative radiotherapy in advanced solid tumors: a pooled analysis (the SHARON project)
Abstract Previous trials showed the tolerability and efficacy of a palliative radiotherapy (RT) regimen (SHARON) based on the 4 fractions delivered in 2 days in different oncological settings. In order to identify possible predictors of symptomatic response, the purpose of this study is to perform a...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-25602-7 |
| _version_ | 1811302199702061056 |
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| author | Costanza Maria Donati Gabriella Macchia Giambattista Siepe Alice Zamagni Anna Benini Francesco Cellini Milly Buwenge Savino Cilla Silvia Cammelli Stefania Rizzo Luciana Caravatta Tigeneh Wondemagegnhu A. F. M. Kamal Uddin Biniyam Tefera Deressa Mostafa A. Sumon Elisa Lodi Rizzini Alberto Bazzocchi Alessio G. Morganti Francesco Deodato Eleonora Farina |
| author_facet | Costanza Maria Donati Gabriella Macchia Giambattista Siepe Alice Zamagni Anna Benini Francesco Cellini Milly Buwenge Savino Cilla Silvia Cammelli Stefania Rizzo Luciana Caravatta Tigeneh Wondemagegnhu A. F. M. Kamal Uddin Biniyam Tefera Deressa Mostafa A. Sumon Elisa Lodi Rizzini Alberto Bazzocchi Alessio G. Morganti Francesco Deodato Eleonora Farina |
| author_sort | Costanza Maria Donati |
| collection | DOAJ |
| description | Abstract Previous trials showed the tolerability and efficacy of a palliative radiotherapy (RT) regimen (SHARON) based on the 4 fractions delivered in 2 days in different oncological settings. In order to identify possible predictors of symptomatic response, the purpose of this study is to perform a pooled analysis of previous trials. We analyzed the impact on symptomatic response of the following parameters: tumor site, histological type, performance status (ECOG), dominant symptom, and RT dose using the Chi-square test and Fisher’s exact test. One-hundred-eighty patients were analyzed. Median RT dose was 20 Gy (range: 14–20 Gy). The overall response rate was 88.8% (95% CI 83.3–92.7%) while pre- and post-treatment mean VAS was 5.3 (± 7.7) and 2.2 (± 2.2), respectively (p < 0.001). The overall response rate of pain, dyspnea, bleeding, dysphagia, and other symptoms was 86.2%, 90.9%, 100%, 87.5%, and 100%, respectively. Comparing the symptomatic effect based on the analyzed parameters no significant differences were recorded. However, patients with locally advanced disease showed a higher rate of symptomatic responses than metastatic ones (97.3% vs 83.0%; p = 0.021). Finally, the complete pain response rate was more than double in patients with mild to moderate (VAS: 4–7) compared to those with severe (VAS > 7) pain (36.0% vs 14.3%; p = 0.028). This pooled analysis showed high efficacy of the SHARON regimen in the relief of several cancer-related symptoms. The markedly and significantly higher complete pain response rate, in patients with mild-moderate pain, suggests early referral to palliative RT for patients with cancer-related pain. |
| first_indexed | 2024-04-13T07:23:47Z |
| format | Article |
| id | doaj.art-9881f89603e648d2807cb4803d4de83c |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T07:23:47Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-9881f89603e648d2807cb4803d4de83c2022-12-22T02:56:32ZengNature PortfolioScientific Reports2045-23222022-12-011211610.1038/s41598-022-25602-7Short course palliative radiotherapy in advanced solid tumors: a pooled analysis (the SHARON project)Costanza Maria Donati0Gabriella Macchia1Giambattista Siepe2Alice Zamagni3Anna Benini4Francesco Cellini5Milly Buwenge6Savino Cilla7Silvia Cammelli8Stefania Rizzo9Luciana Caravatta10Tigeneh Wondemagegnhu11A. F. M. Kamal Uddin12Biniyam Tefera Deressa13Mostafa A. Sumon14Elisa Lodi Rizzini15Alberto Bazzocchi16Alessio G. Morganti17Francesco Deodato18Eleonora Farina19Radiation Oncology, Department of Experimental, Diagnostic and Specialty Medicine-DIMES, Alma Mater Studiorum University of BolognaDipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro CuoreIRCCS Azienda Ospedaliero-Universitaria Di BolognaRadiation Oncology, Department of Experimental, Diagnostic and Specialty Medicine-DIMES, Alma Mater Studiorum University of BolognaRadiation Oncology, Department of Experimental, Diagnostic and Specialty Medicine-DIMES, Alma Mater Studiorum University of BolognaDipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro CuoreRadiation Oncology, Department of Experimental, Diagnostic and Specialty Medicine-DIMES, Alma Mater Studiorum University of BolognaMedical Physics Unit, Gemelli Molise Hospital-Università Cattolica del Sacro CuoreRadiation Oncology, Department of Experimental, Diagnostic and Specialty Medicine-DIMES, Alma Mater Studiorum University of BolognaService of Radiology, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale (EOC)Department of Radiation Oncology, Santissima Annunziata Hospital, Gabriele D’Annunzio University of Chieti-PescaraRadiotherapy Department, Tikur Anbessa Specialized Hospital, Department of Clinical Oncology, College of Medicine and Health Sciences, University of GondarDepartment of Radiation Oncology, United Hospital LimitedRadiotherapy Department, Tikur Anbessa Specialized Hospital, Department of Clinical Oncology, College of Medicine and Health Sciences, University of GondarDepartment of Radiation Oncology, United Hospital LimitedIRCCS Azienda Ospedaliero-Universitaria Di BolognaDiagnostic and Interventional Radiology, IRCCS Istituto Ortopedico RizzoliRadiation Oncology, Department of Experimental, Diagnostic and Specialty Medicine-DIMES, Alma Mater Studiorum University of BolognaDipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro CuoreRadiotherapy Unit, Azienda Ospedaliero-Universitaria Di FerraraAbstract Previous trials showed the tolerability and efficacy of a palliative radiotherapy (RT) regimen (SHARON) based on the 4 fractions delivered in 2 days in different oncological settings. In order to identify possible predictors of symptomatic response, the purpose of this study is to perform a pooled analysis of previous trials. We analyzed the impact on symptomatic response of the following parameters: tumor site, histological type, performance status (ECOG), dominant symptom, and RT dose using the Chi-square test and Fisher’s exact test. One-hundred-eighty patients were analyzed. Median RT dose was 20 Gy (range: 14–20 Gy). The overall response rate was 88.8% (95% CI 83.3–92.7%) while pre- and post-treatment mean VAS was 5.3 (± 7.7) and 2.2 (± 2.2), respectively (p < 0.001). The overall response rate of pain, dyspnea, bleeding, dysphagia, and other symptoms was 86.2%, 90.9%, 100%, 87.5%, and 100%, respectively. Comparing the symptomatic effect based on the analyzed parameters no significant differences were recorded. However, patients with locally advanced disease showed a higher rate of symptomatic responses than metastatic ones (97.3% vs 83.0%; p = 0.021). Finally, the complete pain response rate was more than double in patients with mild to moderate (VAS: 4–7) compared to those with severe (VAS > 7) pain (36.0% vs 14.3%; p = 0.028). This pooled analysis showed high efficacy of the SHARON regimen in the relief of several cancer-related symptoms. The markedly and significantly higher complete pain response rate, in patients with mild-moderate pain, suggests early referral to palliative RT for patients with cancer-related pain.https://doi.org/10.1038/s41598-022-25602-7 |
| spellingShingle | Costanza Maria Donati Gabriella Macchia Giambattista Siepe Alice Zamagni Anna Benini Francesco Cellini Milly Buwenge Savino Cilla Silvia Cammelli Stefania Rizzo Luciana Caravatta Tigeneh Wondemagegnhu A. F. M. Kamal Uddin Biniyam Tefera Deressa Mostafa A. Sumon Elisa Lodi Rizzini Alberto Bazzocchi Alessio G. Morganti Francesco Deodato Eleonora Farina Short course palliative radiotherapy in advanced solid tumors: a pooled analysis (the SHARON project) Scientific Reports |
| title | Short course palliative radiotherapy in advanced solid tumors: a pooled analysis (the SHARON project) |
| title_full | Short course palliative radiotherapy in advanced solid tumors: a pooled analysis (the SHARON project) |
| title_fullStr | Short course palliative radiotherapy in advanced solid tumors: a pooled analysis (the SHARON project) |
| title_full_unstemmed | Short course palliative radiotherapy in advanced solid tumors: a pooled analysis (the SHARON project) |
| title_short | Short course palliative radiotherapy in advanced solid tumors: a pooled analysis (the SHARON project) |
| title_sort | short course palliative radiotherapy in advanced solid tumors a pooled analysis the sharon project |
| url | https://doi.org/10.1038/s41598-022-25602-7 |
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