Involvement of calcium in pain and antinociception
Calcium ions are widely recognized to play a fundamental role in the regulation of several biological processes. Transient changes in cytoplasmic calcium ion concentration represent a key step for neurotransmitter release and the modulation of cell membrane excitability. Evidence has accumulated for...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2001-04-01
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| Series: | Brazilian Journal of Medical and Biological Research |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000400003 |
| _version_ | 1818020658650546176 |
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| author | W.A. Prado |
| author_facet | W.A. Prado |
| author_sort | W.A. Prado |
| collection | DOAJ |
| description | Calcium ions are widely recognized to play a fundamental role in the regulation of several biological processes. Transient changes in cytoplasmic calcium ion concentration represent a key step for neurotransmitter release and the modulation of cell membrane excitability. Evidence has accumulated for the involvement of calcium ions also in nociception and antinociception, including the analgesic effects produced by opioids. The combination of opioids with drugs able to interfere with calcium ion functions in neurons has been pointed out as a useful alternative for safer clinical pain management. Alternatively, drugs that reduce the flux of calcium ions into neurons have been indicated as analgesic alternatives to opioids. This article reviews the manners by which calcium ions penetrate cell membranes and the changes in these mechanisms caused by opioids and calcium antagonists regarding nociceptive and antinociceptive events. |
| first_indexed | 2024-04-14T08:08:17Z |
| format | Article |
| id | doaj.art-98829d393ef8441b8a44a8647c1ccb42 |
| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-04-14T08:08:17Z |
| publishDate | 2001-04-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-98829d393ef8441b8a44a8647c1ccb422022-12-22T02:04:39ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X2001-04-0134444946110.1590/S0100-879X2001000400003Involvement of calcium in pain and antinociceptionW.A. PradoCalcium ions are widely recognized to play a fundamental role in the regulation of several biological processes. Transient changes in cytoplasmic calcium ion concentration represent a key step for neurotransmitter release and the modulation of cell membrane excitability. Evidence has accumulated for the involvement of calcium ions also in nociception and antinociception, including the analgesic effects produced by opioids. The combination of opioids with drugs able to interfere with calcium ion functions in neurons has been pointed out as a useful alternative for safer clinical pain management. Alternatively, drugs that reduce the flux of calcium ions into neurons have been indicated as analgesic alternatives to opioids. This article reviews the manners by which calcium ions penetrate cell membranes and the changes in these mechanisms caused by opioids and calcium antagonists regarding nociceptive and antinociceptive events.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000400003antinociceptionanalgesiacalcium ionscalcium antagonistsopioids |
| spellingShingle | W.A. Prado Involvement of calcium in pain and antinociception Brazilian Journal of Medical and Biological Research antinociception analgesia calcium ions calcium antagonists opioids |
| title | Involvement of calcium in pain and antinociception |
| title_full | Involvement of calcium in pain and antinociception |
| title_fullStr | Involvement of calcium in pain and antinociception |
| title_full_unstemmed | Involvement of calcium in pain and antinociception |
| title_short | Involvement of calcium in pain and antinociception |
| title_sort | involvement of calcium in pain and antinociception |
| topic | antinociception analgesia calcium ions calcium antagonists opioids |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000400003 |
| work_keys_str_mv | AT waprado involvementofcalciuminpainandantinociception |