Synthesis and Antiproliferative Evaluation of Novel Longifolene-Derived Tetralone Derivatives Bearing 1,2,4-Triazole Moiety

Synthesis and Antiproliferative Evaluation of Novel Longifolene-Derived Tetralone Derivatives Bearing 1,2,4-Triazole Moiety

Seventeen novel 2-(5-amino-1-(substituted sulfonyl)-1<i>H</i>-1,2,4-triazol-3-ylthio)-6- isopropyl-4,4-dimethyl-3,4-dihydronaphthalen-1(2<i>H</i>)-one compounds were synthesized from the abundant and naturally renewable longifolene and their structures were confirmed by FT-IR...

Full description

Bibliographic Details
Main Authors:	Xia-Ping Zhu, Gui-Shan Lin, Wen-Gui Duan, Qing-Min Li, Fang-Yao Li, Shun-Zhong Lu
Format:	Article
Language:	English
Published:	MDPI AG 2020-02-01
Series:	Molecules
Subjects:	longifolene-derived tetralone 1,2,4-triazole antiproliferative activity synthesis
Online Access:	https://www.mdpi.com/1420-3049/25/4/986

Similar Items

Exploration of Cytotoxic Potential of Longifolene/Junipene Isolated from <i>Chrysopogon zizanioides</i>
by: Madhuri Grover, et al.
Published: (2022-09-01)

Synthesis, Antifungal Activity, 3D-QSAR and Controlled Release on Hydrotalcite Study of Longifolene-Derived Diphenyl Ether Carboxylic Acid Compounds
by: Xiaocui Wu, et al.
Published: (2023-02-01)

Anti-Trypanosomal and Antimalarial Properties of Tetralone Derivatives and Structurally Related Benzocycloalkanones
by: Richard M. Beteck, et al.
Published: (2019-05-01)

New 1,2,3-Triazole/1,2,4-triazole Hybrids as Aromatase Inhibitors: Design, Synthesis, and Apoptotic Antiproliferative Activity
by: Mohamed T-E Maghraby, et al.
Published: (2023-10-01)

Synthesis and Crystal Structure of Novel Sulfone Derivatives Containing 1,2,4-Triazole Moieties
by: Deyu Hu, et al.
Published: (2010-02-01)

The Effect of 1,2,4-Triazole-3-thiol Derivatives Bearing Hydrazone Moiety on Cancer Cell Migration and Growth of Melanoma, Breast, and Pancreatic Cancer Spheroids
by: Aida Šermukšnytė, et al.
Published: (2022-08-01)

Tetralone derivatives are MIF tautomerase inhibitors and attenuate macrophage activation and amplify the hypothermic response in endotoxemic mice
by: János Garai, et al.
Published: (2021-01-01)

Theoretical Study of Tautomeric Conformations for 1,2,4-Triazole Derivatives
by: Radia Mahboub
Published: (2021-03-01)

New S-alkylated 1,2,4-triazoles incorporating diphenyl sulfone moieties with potential antibacterial activity
by: Barbuceanu Stefania F., et al.
Published: (2009-01-01)

An easy and direct method for the synthesis of 1,2,4-triazole derivatives through carboxylic acids and hydrazinophthalazine
by: Gildardo Rivera, et al.
Published: (2008-01-01)

Design, Synthesis and Fungicidal Activity of New 1,2,4-Triazole Derivatives Containing Oxime Ether and Phenoxyl Pyridinyl Moiety
by: Hui Bai, et al.
Published: (2020-12-01)

Synthesis, Antifungal Activity, 3D-QSAR, and Molecular Docking Study of Novel Menthol-Derived 1,2,4-Triazole-thioether Compounds
by: Mei Huang, et al.
Published: (2021-11-01)

Synthesis and Biological Activity of Substituted Urea and Thiourea Derivatives Containing 1,2,4-Triazole Moieties
by: David E. Wedge, et al.
Published: (2013-03-01)

Design, Synthesis and Biological Activity Evaluation of S-Substituted 1H-5-Mercapto-1,2,4-Triazole Derivatives as Antiproliferative Agents in Colorectal Cancer
by: Marius Mioc, et al.
Published: (2018-08-01)

Microwave-Assisted Synthesis and Antifungal Activity of Some Novel Thioethers Containing 1,2,4-Triazole Moiety
by: Li-Jing Min, et al.
Published: (2015-11-01)

Synthesis and Antifungal Activity of Novel Myrtenal-Based 4-Methyl-1,2,4-triazole-thioethers
by: Gui-Shan Lin, et al.
Published: (2017-01-01)

Determination of antimicrobial activity of some 1,2,4-triazole derivatives
by: M. S. M. Alrawashdeh
Published: (2018-04-01)

(S)-2-[(S)-2,2,2-Trifluoro-1-hydroxyethyl]-1-tetralone
by: Klemen Motaln, et al.
Published: (2023-01-01)

Design, synthesis, and apoptotic antiproliferative action of new 1,2,3-triazole/1,2,4-oxadiazole hybrids as dual EGFR/VEGFR-2 inhibitors
by: Mohamed A. Mahmoud, et al.
Published: (2024-12-01)

Synthesis of 1,6-bis(semicarbazide)hexanes and 1,6-bis(1,2,4-triazol-5-one)hexanes and their antiproliferative and antimicrobial activity
by: Pitucha M., et al.
Published: (2012-01-01)

1,2,4-Triazoles as Important Antibacterial Agents
by: Małgorzata Strzelecka, et al.
Published: (2021-03-01)

Synthesis, antitumor activity, antimicrobial evaluation and molecular docking studies of some hydrazone, 1,3,4-oxadiazole, 1,2,4-triazole and pyrazole derivatives bearing nicotinoyl moiety
by: Abdel-Rahman Farghaly, et al.
Published: (2024-01-01)

Synthesis and Antiproliferative Activity of Triazoles Based on 2-Azabicycloalkanes
by: Franz Steppeler, et al.
Published: (2021-04-01)

Design, synthesis and evaluation of novel 1,2,4-triazole derivatives as promising anticancer agents
by: Leila Emami, et al.
Published: (2022-11-01)

Synthesis and Antiproliferative Evaluation of Novel Hybrids of Dehydroabietic Acid Bearing 1,2,3-Triazole Moiety
by: Fang-Yao Li, et al.
Published: (2019-11-01)

Design, Synthesis, in vitro Antiproliferative Activity, Binding Modeling of 1,2,4,-Triazoles as New Anti-Breast Cancer Agents
by: Murat Genc, et al.
Published: (2016-11-01)

SINTEZA ȘI CERCETAREA PROPRIETĂȚILOR BIOLOGICE ALE UNOR DERIVAȚI AI 4-AMINO-5-METIL-4H-1,2,4-TRIAZOLULUI-3-TIOL
by: Anna RUSNAC, et al.
Published: (2017-03-01)

Novel Coumarin Derivatives Containing 1,2,4-Triazole, 4,5-Dicyanoimidazole and Purine Moieties: Synthesis and Evaluation of Their Cytostatic Activity
by: Mladen Mintas, et al.
Published: (2012-09-01)

Novel agonists of benzodiazepine receptors: Design, synthesis, binding assay and pharmacological evaluation of diphenyl-1,2,4-triazole derivatives
by: Hossein Fasihi, et al.
Published: (2024-01-01)

Elucidation of potential anticancer, antioxidant and antimicrobial properties of some new triazole compounds bearing pyridine-4-yl moiety and cyclobutane ring
by: Pelin Koparir, et al.
Published: (2022-07-01)

Simple and Efficient Synthesis of Racemic 2-(tert-Butoxycarbon-ylamino)-2-methyl-3-(1H-1,2,4-triazol-1-yl)propanoic Acid, a New Derivative of β-(1,2,4-Triazol-1-yl)alanine
by: Abdelali Kerbal, et al.
Published: (2011-04-01)

Synthesis, Structural Analysis and Thermal Behavior of New 1,2,4-Triazole Derivative and Its Transition Metal Complexes
by: Ali Taleb Bader, et al.
Published: (2021-12-01)

Design, Synthesis and Structure-Activity Relationships of Novel Chalcone-1,2,3-triazole-azole Derivates as Antiproliferative Agents
by: Sai-Yang Zhang, et al.
Published: (2016-05-01)

Synthesis, Antioxidant and Antiproliferative Actions of 4-(1,2,3-Triazol-1-yl)quinolin-2(1<i>H</i>)-ones as Multi-Target Inhibitors
by: Essmat M. El-Sheref, et al.
Published: (2023-08-01)

Synthesis methods of 1,2,3-/1,2,4-triazoles: A review
by: Jinlian Dai, et al.
Published: (2022-09-01)

Microwave Assisted Synthesis, Antifungal Activity and DFT Theoretical Study of Some Novel 1,2,4-Triazole Derivatives Containing the 1,2,3-Thiadiazole Moiety
by: Cheng-Xia Tan, et al.
Published: (2013-10-01)

PREDICTION OF ANTIFUNGAL ACTIVITY OF 1,2,4-TRIAZOLE DERIVATIVES USING QSAR MODELS
by: Alexander L. Osipov
Published: (2023-12-01)

Organophosphorus Chemistry: Synthesis of New Phosphonic Acid Derivatives Bearing a Triazole Moiety
by: Esteban Bjerg, et al.
Published: (2022-11-01)

Combination of 1,2,3-triazole and 1,2,4-triazole frameworks for new high-energy and low-sensitivity compounds
by: Wenjing Yao, et al.
Published: (2021-06-01)

Synthesis of new derivatives of hydrazinecarbothioamides and 1,2,4-triazoles and evaluation of their antimicrobial activities
by: Socea Laura I., et al.
Published: (2015-01-01)