Orofacial granulomatosis: A case treated with azithromycin pulse therapy, review of the literature and an algorithm for diagnosis
Orofacial granulomatosis (OFG) describes a disease entity with recurrent or persistent edema within the orofacial region. Microscopically, non-necrotizing granulomas form in the affected tissues in the absence of any recognized systemic disease. The etiologies of OFG are still debatable and poorly u...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | IDCases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214250920302328 |
| _version_ | 1818601644109070336 |
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| author | Carter T. Bruett Bryan R. Trump David R. Adams Leslie R. Halpern |
| author_facet | Carter T. Bruett Bryan R. Trump David R. Adams Leslie R. Halpern |
| author_sort | Carter T. Bruett |
| collection | DOAJ |
| description | Orofacial granulomatosis (OFG) describes a disease entity with recurrent or persistent edema within the orofacial region. Microscopically, non-necrotizing granulomas form in the affected tissues in the absence of any recognized systemic disease. The etiologies of OFG are still debatable and poorly understood. Hypotheses are abundant as to the pathogenesis, which include genetic causes, allergic reactions to food or dental materials, infectious agents, and immunologic dysfunction. OFG also accounts for two other disease processes in a spectrum of nonspecific granulomatous diseases. Management of OFG is often challenging as there exists no singular medication which has been tested or approved for the treatment of the disease. We present an unusual case successfully treated with azithromycin pulse therapy, a literature review on the recent therapeutic options and an algorithm for the treatment of OFG. |
| first_indexed | 2024-12-16T12:54:39Z |
| format | Article |
| id | doaj.art-988531bdd8a64cfca436928b56534166 |
| institution | Directory Open Access Journal |
| issn | 2214-2509 |
| language | English |
| last_indexed | 2024-12-16T12:54:39Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IDCases |
| spelling | doaj.art-988531bdd8a64cfca436928b565341662022-12-21T22:31:03ZengElsevierIDCases2214-25092020-01-0121e00924Orofacial granulomatosis: A case treated with azithromycin pulse therapy, review of the literature and an algorithm for diagnosisCarter T. Bruett0Bryan R. Trump1David R. Adams2Leslie R. Halpern3University of Utah School of Dentistry, United StatesUniversity of Utah School of Dentistry, Section of Oral Pathology, United StatesUniversity of Utah School of Dentistry, Department of Oral Surgery, United StatesUniversity of Utah School of Dentistry, Department of Oral Surgery, United States; Corresponding author at: 530 S. Wakara Way, Salt Lake City, UT, 84108, United States.Orofacial granulomatosis (OFG) describes a disease entity with recurrent or persistent edema within the orofacial region. Microscopically, non-necrotizing granulomas form in the affected tissues in the absence of any recognized systemic disease. The etiologies of OFG are still debatable and poorly understood. Hypotheses are abundant as to the pathogenesis, which include genetic causes, allergic reactions to food or dental materials, infectious agents, and immunologic dysfunction. OFG also accounts for two other disease processes in a spectrum of nonspecific granulomatous diseases. Management of OFG is often challenging as there exists no singular medication which has been tested or approved for the treatment of the disease. We present an unusual case successfully treated with azithromycin pulse therapy, a literature review on the recent therapeutic options and an algorithm for the treatment of OFG.http://www.sciencedirect.com/science/article/pii/S2214250920302328Orofacial granulomatosisGranulomatous cheilitisAzithromycin pulse therapyRecurrent orofacial edema |
| spellingShingle | Carter T. Bruett Bryan R. Trump David R. Adams Leslie R. Halpern Orofacial granulomatosis: A case treated with azithromycin pulse therapy, review of the literature and an algorithm for diagnosis IDCases Orofacial granulomatosis Granulomatous cheilitis Azithromycin pulse therapy Recurrent orofacial edema |
| title | Orofacial granulomatosis: A case treated with azithromycin pulse therapy, review of the literature and an algorithm for diagnosis |
| title_full | Orofacial granulomatosis: A case treated with azithromycin pulse therapy, review of the literature and an algorithm for diagnosis |
| title_fullStr | Orofacial granulomatosis: A case treated with azithromycin pulse therapy, review of the literature and an algorithm for diagnosis |
| title_full_unstemmed | Orofacial granulomatosis: A case treated with azithromycin pulse therapy, review of the literature and an algorithm for diagnosis |
| title_short | Orofacial granulomatosis: A case treated with azithromycin pulse therapy, review of the literature and an algorithm for diagnosis |
| title_sort | orofacial granulomatosis a case treated with azithromycin pulse therapy review of the literature and an algorithm for diagnosis |
| topic | Orofacial granulomatosis Granulomatous cheilitis Azithromycin pulse therapy Recurrent orofacial edema |
| url | http://www.sciencedirect.com/science/article/pii/S2214250920302328 |
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