Clinical applications of gonadotropin-releasing hormone analogues: a broad impact on reproductive medicine
Gonadotropin-releasing hormone (GnRH) is central to the control of the entire hypothalamic-pituitary-gonadal axis. Manipulation of GnRH, in turn, regulates pituitary response and ovarian hormone production. Gonadotropin-releasing hormone analogues have revolutionized assisted reproductive technology...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | F&S Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666334123000089 |
| _version_ | 1797829085983932416 |
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| author | Farrah L. Saleh, M.D. Hugh S. Taylor, M.D. |
| author_facet | Farrah L. Saleh, M.D. Hugh S. Taylor, M.D. |
| author_sort | Farrah L. Saleh, M.D. |
| collection | DOAJ |
| description | Gonadotropin-releasing hormone (GnRH) is central to the control of the entire hypothalamic-pituitary-gonadal axis. Manipulation of GnRH, in turn, regulates pituitary response and ovarian hormone production. Gonadotropin-releasing hormone analogues have revolutionized assisted reproductive technology and gynecologic practice. The recent advent of oral GnRH antagonists with an inherent rapid onset of action continues to transform the treatment options available for several common gynecologic conditions, including endometriosis and fibroids. Herein, we review neuroendocrine GnRH activity and discuss modulation of the reproductive axis by GnRH analogues for diverse clinical applications. |
| first_indexed | 2024-04-09T13:14:49Z |
| format | Article |
| id | doaj.art-9885d3d926184592bb9fcbcd6673d12b |
| institution | Directory Open Access Journal |
| issn | 2666-3341 |
| language | English |
| last_indexed | 2024-04-09T13:14:49Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | F&S Reports |
| spelling | doaj.art-9885d3d926184592bb9fcbcd6673d12b2023-05-12T04:17:14ZengElsevierF&S Reports2666-33412023-06-01428387Clinical applications of gonadotropin-releasing hormone analogues: a broad impact on reproductive medicineFarrah L. Saleh, M.D.0Hugh S. Taylor, M.D.1Section of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, ConnecticutReprint requests: Hugh S. Taylor, M.D., Section of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520.; Section of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, ConnecticutGonadotropin-releasing hormone (GnRH) is central to the control of the entire hypothalamic-pituitary-gonadal axis. Manipulation of GnRH, in turn, regulates pituitary response and ovarian hormone production. Gonadotropin-releasing hormone analogues have revolutionized assisted reproductive technology and gynecologic practice. The recent advent of oral GnRH antagonists with an inherent rapid onset of action continues to transform the treatment options available for several common gynecologic conditions, including endometriosis and fibroids. Herein, we review neuroendocrine GnRH activity and discuss modulation of the reproductive axis by GnRH analogues for diverse clinical applications.http://www.sciencedirect.com/science/article/pii/S2666334123000089Gonadotropin-releasing hormoneGnRHGnRH analogueinfertilityendometriosis |
| spellingShingle | Farrah L. Saleh, M.D. Hugh S. Taylor, M.D. Clinical applications of gonadotropin-releasing hormone analogues: a broad impact on reproductive medicine F&S Reports Gonadotropin-releasing hormone GnRH GnRH analogue infertility endometriosis |
| title | Clinical applications of gonadotropin-releasing hormone analogues: a broad impact on reproductive medicine |
| title_full | Clinical applications of gonadotropin-releasing hormone analogues: a broad impact on reproductive medicine |
| title_fullStr | Clinical applications of gonadotropin-releasing hormone analogues: a broad impact on reproductive medicine |
| title_full_unstemmed | Clinical applications of gonadotropin-releasing hormone analogues: a broad impact on reproductive medicine |
| title_short | Clinical applications of gonadotropin-releasing hormone analogues: a broad impact on reproductive medicine |
| title_sort | clinical applications of gonadotropin releasing hormone analogues a broad impact on reproductive medicine |
| topic | Gonadotropin-releasing hormone GnRH GnRH analogue infertility endometriosis |
| url | http://www.sciencedirect.com/science/article/pii/S2666334123000089 |
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