Design and Synthesis of Novel N-Benzylidenesulfonohydrazide Inhibitors of MurC and MurD as Potential Antibacterial Agents
A series of novel N-benzylidenesulfonohydrazide compounds were designedand synthesized as inhibitors of UDP-N-acetylmuramic acid:L-alanine ligase (MurC) andUDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase (MurD) from E. coli, involved inthe biosynthesis of bacterial cell-walls. Some compounds posse...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2008-01-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/13/1/11/ |
| _version_ | 1818424916093960192 |
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| author | AleÅ¡ Obreza Slavko PeÄÂar Stanislav Gobec Didier Blanot Andreja KovaÄ Rok Frlan |
| author_facet | AleÅ¡ Obreza Slavko PeÄÂar Stanislav Gobec Didier Blanot Andreja KovaÄ Rok Frlan |
| author_sort | Aleš Obreza |
| collection | DOAJ |
| description | A series of novel N-benzylidenesulfonohydrazide compounds were designedand synthesized as inhibitors of UDP-N-acetylmuramic acid:L-alanine ligase (MurC) andUDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase (MurD) from E. coli, involved inthe biosynthesis of bacterial cell-walls. Some compounds possessed inhibitory activityagainst both enzymes with IC50 values as low as 30 μM. In addition, a new, one-potsynthesis of amidobenzaldehydes is reported. |
| first_indexed | 2024-12-14T14:05:38Z |
| format | Article |
| id | doaj.art-988857da4db046daacec8dc29ac56b1a |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-14T14:05:38Z |
| publishDate | 2008-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-988857da4db046daacec8dc29ac56b1a2022-12-21T22:58:32ZengMDPI AGMolecules1420-30492008-01-01131113010.3390/molecules13010011Design and Synthesis of Novel N-Benzylidenesulfonohydrazide Inhibitors of MurC and MurD as Potential Antibacterial AgentsAleÅ¡ ObrezaSlavko PeÄÂarStanislav GobecDidier BlanotAndreja KovaÄÂRok FrlanA series of novel N-benzylidenesulfonohydrazide compounds were designedand synthesized as inhibitors of UDP-N-acetylmuramic acid:L-alanine ligase (MurC) andUDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase (MurD) from E. coli, involved inthe biosynthesis of bacterial cell-walls. Some compounds possessed inhibitory activityagainst both enzymes with IC50 values as low as 30 μM. In addition, a new, one-potsynthesis of amidobenzaldehydes is reported.http://www.mdpi.com/1420-3049/13/1/11/MurCMurDamidobenzaldehydeinhibitorsantibacterialhydrazide. |
| spellingShingle | AleÅ¡ Obreza Slavko PeÄÂar Stanislav Gobec Didier Blanot Andreja KovaÄ Rok Frlan Design and Synthesis of Novel N-Benzylidenesulfonohydrazide Inhibitors of MurC and MurD as Potential Antibacterial Agents Molecules MurC MurD amidobenzaldehyde inhibitors antibacterial hydrazide. |
| title | Design and Synthesis of Novel N-Benzylidenesulfonohydrazide Inhibitors of MurC and MurD as Potential Antibacterial Agents |
| title_full | Design and Synthesis of Novel N-Benzylidenesulfonohydrazide Inhibitors of MurC and MurD as Potential Antibacterial Agents |
| title_fullStr | Design and Synthesis of Novel N-Benzylidenesulfonohydrazide Inhibitors of MurC and MurD as Potential Antibacterial Agents |
| title_full_unstemmed | Design and Synthesis of Novel N-Benzylidenesulfonohydrazide Inhibitors of MurC and MurD as Potential Antibacterial Agents |
| title_short | Design and Synthesis of Novel N-Benzylidenesulfonohydrazide Inhibitors of MurC and MurD as Potential Antibacterial Agents |
| title_sort | design and synthesis of novel n benzylidenesulfonohydrazide inhibitors of murc and murd as potential antibacterial agents |
| topic | MurC MurD amidobenzaldehyde inhibitors antibacterial hydrazide. |
| url | http://www.mdpi.com/1420-3049/13/1/11/ |
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