Síntese de amidas e sulfonamidas de beta-D-galactopiranosilamina e beta-lactosilamina e avaliação de suas interações com lectinas de Erythrina cristagalli e de Ricinus communis Synthesis of amides and sulfonamides of beta-D- galactopyranosylamine and beta-lactosylamine and evaluation of their interactions with the lectins from Erythrina cristagalli and Ricinus communis
<abstract language="eng">We report herein the synthesis of some beta-D-galactopyranosylamine and beta-lactosylamine amides and sulfonamides. The interactions of these compounds with lectins from the seeds of Erythrina cristagalli (LEC) and Ricinus communis (RCA120) were evaluated in...
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| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Química
2007-10-01
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| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422007000500040 |
| _version_ | 1818968251586052096 |
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| author | Anna Paola Butera José Dias de Souza Filho Diogo Teixeira Carvalho Rute Cunha Figueiredo Luiz Carlos Alves de Faria Maria Angélica Nunes Maria Auxiliadora Fontes Prado Ricardo José Alves Milton Hércules Guerra de Andrade Karina Taciana Santos Silva |
| author_facet | Anna Paola Butera José Dias de Souza Filho Diogo Teixeira Carvalho Rute Cunha Figueiredo Luiz Carlos Alves de Faria Maria Angélica Nunes Maria Auxiliadora Fontes Prado Ricardo José Alves Milton Hércules Guerra de Andrade Karina Taciana Santos Silva |
| author_sort | Anna Paola Butera |
| collection | DOAJ |
| description | <abstract language="eng">We report herein the synthesis of some beta-D-galactopyranosylamine and beta-lactosylamine amides and sulfonamides. The interactions of these compounds with lectins from the seeds of Erythrina cristagalli (LEC) and Ricinus communis (RCA120) were evaluated in a hemagglutination inhibitory activity assay. D-Galactose and lactose were used as reference compounds. The beta-lactosylamine amides and sulfonamides were nearly as active as lactose in inhibiting LEC mediated hemagglutination and were less active against RCA120 agglutinin. The beta-D-galactopyranosylamine amides and sulfonamides were, with one exception, considerably less active than D-galactose in the assay with both lectins. |
| first_indexed | 2024-12-20T14:01:43Z |
| format | Article |
| id | doaj.art-98888ab86c474aae92fb8159ea83e2f3 |
| institution | Directory Open Access Journal |
| issn | 0100-4042 1678-7064 |
| language | English |
| last_indexed | 2024-12-20T14:01:43Z |
| publishDate | 2007-10-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-98888ab86c474aae92fb8159ea83e2f32022-12-21T19:38:21ZengSociedade Brasileira de QuímicaQuímica Nova0100-40421678-70642007-10-013051267127410.1590/S0100-40422007000500040Síntese de amidas e sulfonamidas de beta-D-galactopiranosilamina e beta-lactosilamina e avaliação de suas interações com lectinas de Erythrina cristagalli e de Ricinus communis Synthesis of amides and sulfonamides of beta-D- galactopyranosylamine and beta-lactosylamine and evaluation of their interactions with the lectins from Erythrina cristagalli and Ricinus communisAnna Paola ButeraJosé Dias de Souza FilhoDiogo Teixeira CarvalhoRute Cunha FigueiredoLuiz Carlos Alves de FariaMaria Angélica NunesMaria Auxiliadora Fontes PradoRicardo José AlvesMilton Hércules Guerra de AndradeKarina Taciana Santos Silva<abstract language="eng">We report herein the synthesis of some beta-D-galactopyranosylamine and beta-lactosylamine amides and sulfonamides. The interactions of these compounds with lectins from the seeds of Erythrina cristagalli (LEC) and Ricinus communis (RCA120) were evaluated in a hemagglutination inhibitory activity assay. D-Galactose and lactose were used as reference compounds. The beta-lactosylamine amides and sulfonamides were nearly as active as lactose in inhibiting LEC mediated hemagglutination and were less active against RCA120 agglutinin. The beta-D-galactopyranosylamine amides and sulfonamides were, with one exception, considerably less active than D-galactose in the assay with both lectins.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422007000500040carbohydratesplant lectinsamides |
| spellingShingle | Anna Paola Butera José Dias de Souza Filho Diogo Teixeira Carvalho Rute Cunha Figueiredo Luiz Carlos Alves de Faria Maria Angélica Nunes Maria Auxiliadora Fontes Prado Ricardo José Alves Milton Hércules Guerra de Andrade Karina Taciana Santos Silva Síntese de amidas e sulfonamidas de beta-D-galactopiranosilamina e beta-lactosilamina e avaliação de suas interações com lectinas de Erythrina cristagalli e de Ricinus communis Synthesis of amides and sulfonamides of beta-D- galactopyranosylamine and beta-lactosylamine and evaluation of their interactions with the lectins from Erythrina cristagalli and Ricinus communis Química Nova carbohydrates plant lectins amides |
| title | Síntese de amidas e sulfonamidas de beta-D-galactopiranosilamina e beta-lactosilamina e avaliação de suas interações com lectinas de Erythrina cristagalli e de Ricinus communis Synthesis of amides and sulfonamides of beta-D- galactopyranosylamine and beta-lactosylamine and evaluation of their interactions with the lectins from Erythrina cristagalli and Ricinus communis |
| title_full | Síntese de amidas e sulfonamidas de beta-D-galactopiranosilamina e beta-lactosilamina e avaliação de suas interações com lectinas de Erythrina cristagalli e de Ricinus communis Synthesis of amides and sulfonamides of beta-D- galactopyranosylamine and beta-lactosylamine and evaluation of their interactions with the lectins from Erythrina cristagalli and Ricinus communis |
| title_fullStr | Síntese de amidas e sulfonamidas de beta-D-galactopiranosilamina e beta-lactosilamina e avaliação de suas interações com lectinas de Erythrina cristagalli e de Ricinus communis Synthesis of amides and sulfonamides of beta-D- galactopyranosylamine and beta-lactosylamine and evaluation of their interactions with the lectins from Erythrina cristagalli and Ricinus communis |
| title_full_unstemmed | Síntese de amidas e sulfonamidas de beta-D-galactopiranosilamina e beta-lactosilamina e avaliação de suas interações com lectinas de Erythrina cristagalli e de Ricinus communis Synthesis of amides and sulfonamides of beta-D- galactopyranosylamine and beta-lactosylamine and evaluation of their interactions with the lectins from Erythrina cristagalli and Ricinus communis |
| title_short | Síntese de amidas e sulfonamidas de beta-D-galactopiranosilamina e beta-lactosilamina e avaliação de suas interações com lectinas de Erythrina cristagalli e de Ricinus communis Synthesis of amides and sulfonamides of beta-D- galactopyranosylamine and beta-lactosylamine and evaluation of their interactions with the lectins from Erythrina cristagalli and Ricinus communis |
| title_sort | sintese de amidas e sulfonamidas de beta d galactopiranosilamina e beta lactosilamina e avaliacao de suas interacoes com lectinas de erythrina cristagalli e de ricinus communis synthesis of amides and sulfonamides of beta d galactopyranosylamine and beta lactosylamine and evaluation of their interactions with the lectins from erythrina cristagalli and ricinus communis |
| topic | carbohydrates plant lectins amides |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422007000500040 |
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