Association between Serum Triglycerides and Prostate Specific Antigen (PSA) among U.S. Males: National Health and Nutrition Examination Survey (NHANES), 2003–2010
(1) Background: Increasing evidence indicates that lipid metabolism may influence the concentration of prostate-specific antigen (PSA). However, the association between triglycerides and PSA remains unclear and complicated. Hence, we evaluated the correlation between triglycerides and PSA based on t...
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MDPI AG
2022-03-01
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| Online Access: | https://www.mdpi.com/2072-6643/14/7/1325 |
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| author | Chengcheng Wei Liang Tian Bo Jia Miao Wang Ming Xiong Bo Hu Changqi Deng Yaxin Hou Teng Hou Xiong Yang Zhaohui Chen |
| author_facet | Chengcheng Wei Liang Tian Bo Jia Miao Wang Ming Xiong Bo Hu Changqi Deng Yaxin Hou Teng Hou Xiong Yang Zhaohui Chen |
| author_sort | Chengcheng Wei |
| collection | DOAJ |
| description | (1) Background: Increasing evidence indicates that lipid metabolism may influence the concentration of prostate-specific antigen (PSA). However, the association between triglycerides and PSA remains unclear and complicated. Hence, we evaluated the correlation between triglycerides and PSA based on the U.S. National Health and Nutrition Examination Survey (NHANES) database. (2) Methods: A total of 2910 participants out of 41,156 participants fit into our study after conducting the screening from the 2003 to 2010 NHANES survey. Serum triglycerides were the independent variable of our study, and PSA was the dependent variable; (3) Results: In our study, the average age of chosen participants was 59.7 years (±12.7). After adjusting for covariates, the result indicated that for each additional unit of serum triglyceride (mg/dL), the PSA concentrations were reduced by 0.0043 ng/mL (−0.0082, −0.0005) with a statistical difference. Furthermore, we used machine learning of the XGBoost model to determine the relative importance of selected variables as well as constructed a smooth curve based on the fully adjusted model to investigate the possible linear relationship between the triglyceride and PSA concentrations. (4) Conclusions: The serum triglyceride is independently and negatively correlated with PSA among American males, which may make it hard to detect asymptomatic prostate cancer and diagnose at an advance stage with higher triglycerides due to detection bias. |
| first_indexed | 2024-03-09T11:33:43Z |
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| id | doaj.art-988ac3745b2b46528ba5613fc4275a24 |
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| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T11:33:43Z |
| publishDate | 2022-03-01 |
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| spelling | doaj.art-988ac3745b2b46528ba5613fc4275a242023-11-30T23:46:38ZengMDPI AGNutrients2072-66432022-03-01147132510.3390/nu14071325Association between Serum Triglycerides and Prostate Specific Antigen (PSA) among U.S. Males: National Health and Nutrition Examination Survey (NHANES), 2003–2010Chengcheng Wei0Liang Tian1Bo Jia2Miao Wang3Ming Xiong4Bo Hu5Changqi Deng6Yaxin Hou7Teng Hou8Xiong Yang9Zhaohui Chen10Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, ChinaDepartment of Urology, Wuhan Red Cross Hospital, Wuhan 430015, ChinaPeople’s Hospital of Dongxihu District, Wuhan 430040, ChinaDepartment of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, ChinaDepartment of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, ChinaPeople’s Hospital of Dongxihu District, Wuhan 430040, ChinaDepartment of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, ChinaDepartment of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, ChinaDepartment of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, ChinaDepartment of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, ChinaDepartment of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, China(1) Background: Increasing evidence indicates that lipid metabolism may influence the concentration of prostate-specific antigen (PSA). However, the association between triglycerides and PSA remains unclear and complicated. Hence, we evaluated the correlation between triglycerides and PSA based on the U.S. National Health and Nutrition Examination Survey (NHANES) database. (2) Methods: A total of 2910 participants out of 41,156 participants fit into our study after conducting the screening from the 2003 to 2010 NHANES survey. Serum triglycerides were the independent variable of our study, and PSA was the dependent variable; (3) Results: In our study, the average age of chosen participants was 59.7 years (±12.7). After adjusting for covariates, the result indicated that for each additional unit of serum triglyceride (mg/dL), the PSA concentrations were reduced by 0.0043 ng/mL (−0.0082, −0.0005) with a statistical difference. Furthermore, we used machine learning of the XGBoost model to determine the relative importance of selected variables as well as constructed a smooth curve based on the fully adjusted model to investigate the possible linear relationship between the triglyceride and PSA concentrations. (4) Conclusions: The serum triglyceride is independently and negatively correlated with PSA among American males, which may make it hard to detect asymptomatic prostate cancer and diagnose at an advance stage with higher triglycerides due to detection bias.https://www.mdpi.com/2072-6643/14/7/1325prostate-specific antigentriglyceridesNational Health and Nutrition Examination Survey (NHANES)prostate cancermachine learning |
| spellingShingle | Chengcheng Wei Liang Tian Bo Jia Miao Wang Ming Xiong Bo Hu Changqi Deng Yaxin Hou Teng Hou Xiong Yang Zhaohui Chen Association between Serum Triglycerides and Prostate Specific Antigen (PSA) among U.S. Males: National Health and Nutrition Examination Survey (NHANES), 2003–2010 Nutrients prostate-specific antigen triglycerides National Health and Nutrition Examination Survey (NHANES) prostate cancer machine learning |
| title | Association between Serum Triglycerides and Prostate Specific Antigen (PSA) among U.S. Males: National Health and Nutrition Examination Survey (NHANES), 2003–2010 |
| title_full | Association between Serum Triglycerides and Prostate Specific Antigen (PSA) among U.S. Males: National Health and Nutrition Examination Survey (NHANES), 2003–2010 |
| title_fullStr | Association between Serum Triglycerides and Prostate Specific Antigen (PSA) among U.S. Males: National Health and Nutrition Examination Survey (NHANES), 2003–2010 |
| title_full_unstemmed | Association between Serum Triglycerides and Prostate Specific Antigen (PSA) among U.S. Males: National Health and Nutrition Examination Survey (NHANES), 2003–2010 |
| title_short | Association between Serum Triglycerides and Prostate Specific Antigen (PSA) among U.S. Males: National Health and Nutrition Examination Survey (NHANES), 2003–2010 |
| title_sort | association between serum triglycerides and prostate specific antigen psa among u s males national health and nutrition examination survey nhanes 2003 2010 |
| topic | prostate-specific antigen triglycerides National Health and Nutrition Examination Survey (NHANES) prostate cancer machine learning |
| url | https://www.mdpi.com/2072-6643/14/7/1325 |
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