Markers and regulatory mechanisms in ovarian carcinoma
Оvarian carcinoma is one of widely spread malignant diseases of female reproductive system. Mortality rate from it is much higher than from other female malignant diseases. During last 20 years the level of ovarian carcinoma in Ukraine and vast majority of other countries remains high manifesting n...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2014-08-01
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| Series: | The Ukrainian Biochemical Journal |
| Subjects: | |
| Online Access: | http://ukrbiochemjournal.org/wp-content/uploads/2015/06/Paryzhak_4_14.pdf |
| _version_ | 1797428323995877376 |
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| author | S. Ya. Paryzhak O. I. Yakubets Z. D. Vorobets |
| author_facet | S. Ya. Paryzhak O. I. Yakubets Z. D. Vorobets |
| author_sort | S. Ya. Paryzhak |
| collection | DOAJ |
| description | Оvarian carcinoma is one of widely spread malignant diseases of female reproductive system. Mortality rate from it is much higher than from other female malignant diseases. During last 20 years the level of ovarian carcinoma in Ukraine and vast majority of other countries remains high manifesting no signs of decrease. This arouses interest of researchers to development of new methods of early diagnosis, therapeutic approach, prognostic criteria, especially biochemical ones, and means of prophylaxis of this pathology in medical scientific society. At present there are no specific diagnostic tests which would allow revealing the tumor on the initial stages of its development. In spite of vide arsenal of tumor markers, the only reliable test for ovarian carcinoma is determination of antigen СА 125. The results of basic modern research are discussed in this survey. They are aimed at finding out regulatory mechanisms connected with metabolism of L-arginine, activities of ATP-hydrolase systems and searching new markers of ovarian carcinoma. The main possible candidates for this role are determined. |
| first_indexed | 2024-03-09T08:56:23Z |
| format | Article |
| id | doaj.art-988b126cfb08462698b1bc1676baaecb |
| institution | Directory Open Access Journal |
| issn | 2409-4943 2413-5003 |
| language | English |
| last_indexed | 2024-03-09T08:56:23Z |
| publishDate | 2014-08-01 |
| publisher | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry |
| record_format | Article |
| series | The Ukrainian Biochemical Journal |
| spelling | doaj.art-988b126cfb08462698b1bc1676baaecb2023-12-02T12:56:57ZengNational Academy of Sciences of Ukraine, Palladin Institute of BiochemistryThe Ukrainian Biochemical Journal2409-49432413-50032014-08-01864365010.15407/ubj86.04.036Markers and regulatory mechanisms in ovarian carcinomaS. Ya. Paryzhak0 O. I. Yakubets1 Z. D. Vorobets2Lviv Danylo Halytsky National Medical University, Ukraine;Lviv Danylo Halytsky National Medical University, Ukraine;Lviv Danylo Halytsky National Medical University, Ukraine;Оvarian carcinoma is one of widely spread malignant diseases of female reproductive system. Mortality rate from it is much higher than from other female malignant diseases. During last 20 years the level of ovarian carcinoma in Ukraine and vast majority of other countries remains high manifesting no signs of decrease. This arouses interest of researchers to development of new methods of early diagnosis, therapeutic approach, prognostic criteria, especially biochemical ones, and means of prophylaxis of this pathology in medical scientific society. At present there are no specific diagnostic tests which would allow revealing the tumor on the initial stages of its development. In spite of vide arsenal of tumor markers, the only reliable test for ovarian carcinoma is determination of antigen СА 125. The results of basic modern research are discussed in this survey. They are aimed at finding out regulatory mechanisms connected with metabolism of L-arginine, activities of ATP-hydrolase systems and searching new markers of ovarian carcinoma. The main possible candidates for this role are determined.http://ukrbiochemjournal.org/wp-content/uploads/2015/06/Paryzhak_4_14.pdfactivities of ATP-hydrolasesantigen CA-125L-arginine metabolismregulatory mechanismstumor markersоvarian carcinoma |
| spellingShingle | S. Ya. Paryzhak O. I. Yakubets Z. D. Vorobets Markers and regulatory mechanisms in ovarian carcinoma The Ukrainian Biochemical Journal activities of ATP-hydrolases antigen CA-125 L-arginine metabolism regulatory mechanisms tumor markers оvarian carcinoma |
| title | Markers and regulatory mechanisms in ovarian carcinoma |
| title_full | Markers and regulatory mechanisms in ovarian carcinoma |
| title_fullStr | Markers and regulatory mechanisms in ovarian carcinoma |
| title_full_unstemmed | Markers and regulatory mechanisms in ovarian carcinoma |
| title_short | Markers and regulatory mechanisms in ovarian carcinoma |
| title_sort | markers and regulatory mechanisms in ovarian carcinoma |
| topic | activities of ATP-hydrolases antigen CA-125 L-arginine metabolism regulatory mechanisms tumor markers оvarian carcinoma |
| url | http://ukrbiochemjournal.org/wp-content/uploads/2015/06/Paryzhak_4_14.pdf |
| work_keys_str_mv | AT syaparyzhak markersandregulatorymechanismsinovariancarcinoma AT oiyakubets markersandregulatorymechanismsinovariancarcinoma AT zdvorobets markersandregulatorymechanismsinovariancarcinoma |