Drosophila macrophages switch to aerobic glycolysis to mount effective antibacterial defense

Drosophila macrophages switch to aerobic glycolysis to mount effective antibacterial defense

Macrophage-mediated phagocytosis and cytokine production represent the front lines of resistance to bacterial invaders. A key feature of this pro-inflammatory response in mammals is the complex remodeling of cellular metabolism towards aerobic glycolysis. Although the function of bactericidal macrop...

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Bibliographic Details
Main Authors: Gabriela Krejčová, Adéla Danielová, Pavla Nedbalová, Michalina Kazek, Lukáš Strych, Geetanjali Chawla, Jason M Tennessen, Jaroslava Lieskovská, Marek Jindra, Tomáš Doležal, Adam Bajgar
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-10-01
Series:eLife
Subjects:
aerobic glycolysis
Warburg effect
polarization of macrophages
bacterial infection
HIF1α
immunometabolism
Online Access:https://elifesciences.org/articles/50414

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