Deacetylated Sialic Acid Sensitizes Lung and Colon Cancers to Novel Cucurbitacin-Inspired Estrone Epidermal Growth Factor Receptor (EGFR) Inhibitor Analogs

Deacetylated Sialic Acid Sensitizes Lung and Colon Cancers to Novel Cucurbitacin-Inspired Estrone Epidermal Growth Factor Receptor (EGFR) Inhibitor Analogs

Cancers utilize sugar residues such as sialic acids (Sia) to improve their ability to survive. Sia presents a variety of functional group alterations, including O-acetylation on the C6 hydroxylated tail. Previously, sialylation has been reported to suppress EGFR activation and increase cancer cell s...

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Bibliographic Details
Main Authors: Mathias T. Anim, Isaac Tuffour, Rylan Willis, Matthew Schell, Trevor Ostlund, Mater H. Mahnashi, Fathi Halaweish, Rachel Willand-Charnley
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Molecules
Subjects:
sialic acid
CASD1
apoptosis
estrone analogs
Epidermal Growth Factor Receptor (EGFR)
Online Access:https://www.mdpi.com/1420-3049/28/17/6257

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