A Compendium of Information on the Lysosome
For a long time, lysosomes were considered as mere waste bags for cellular constituents. Thankfully, studies carried out in the past 15 years were brimming with elegant and crucial breakthroughs in lysosome research, uncovering their complex roles as nutrient sensors and characterizing them as cruci...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.798262/full |
| _version_ | 1819176664334073856 |
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| author | Nadia Bouhamdani Nadia Bouhamdani Nadia Bouhamdani Dominique Comeau Dominique Comeau Sandra Turcotte Sandra Turcotte |
| author_facet | Nadia Bouhamdani Nadia Bouhamdani Nadia Bouhamdani Dominique Comeau Dominique Comeau Sandra Turcotte Sandra Turcotte |
| author_sort | Nadia Bouhamdani |
| collection | DOAJ |
| description | For a long time, lysosomes were considered as mere waste bags for cellular constituents. Thankfully, studies carried out in the past 15 years were brimming with elegant and crucial breakthroughs in lysosome research, uncovering their complex roles as nutrient sensors and characterizing them as crucial multifaceted signaling organelles. This review presents the scientific knowledge on lysosome physiology and functions, starting with their discovery and reviewing up to date ground-breaking discoveries highlighting their heterogeneous functions as well as pending questions that remain to be answered. We also review the roles of lysosomes in anti-cancer drug resistance and how they undergo a series of molecular and functional changes during malignant transformation which lead to tumor aggression, angiogenesis, and metastases. Finally, we discuss the strategy of targeting lysosomes in cancer which could lead to the development of new and effective targeted therapies. |
| first_indexed | 2024-12-22T21:14:14Z |
| format | Article |
| id | doaj.art-988e36504bac4d23b49574ab08014008 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-22T21:14:14Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-988e36504bac4d23b49574ab080140082022-12-21T18:12:25ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-12-01910.3389/fcell.2021.798262798262A Compendium of Information on the LysosomeNadia Bouhamdani0Nadia Bouhamdani1Nadia Bouhamdani2Dominique Comeau3Dominique Comeau4Sandra Turcotte5Sandra Turcotte6Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB, CanadaDr. Georges-L. Dumont University Hospital Centre, Clinical Research Sector, Vitalité Health Network, Moncton, NB, CanadaAtlantic Cancer Research Institute, Moncton, NB, CanadaDepartment of Chemistry and Biochemistry, Université de Moncton, Moncton, NB, CanadaAtlantic Cancer Research Institute, Moncton, NB, CanadaDepartment of Chemistry and Biochemistry, Université de Moncton, Moncton, NB, CanadaAtlantic Cancer Research Institute, Moncton, NB, CanadaFor a long time, lysosomes were considered as mere waste bags for cellular constituents. Thankfully, studies carried out in the past 15 years were brimming with elegant and crucial breakthroughs in lysosome research, uncovering their complex roles as nutrient sensors and characterizing them as crucial multifaceted signaling organelles. This review presents the scientific knowledge on lysosome physiology and functions, starting with their discovery and reviewing up to date ground-breaking discoveries highlighting their heterogeneous functions as well as pending questions that remain to be answered. We also review the roles of lysosomes in anti-cancer drug resistance and how they undergo a series of molecular and functional changes during malignant transformation which lead to tumor aggression, angiogenesis, and metastases. Finally, we discuss the strategy of targeting lysosomes in cancer which could lead to the development of new and effective targeted therapies.https://www.frontiersin.org/articles/10.3389/fcell.2021.798262/fulllysosomeautophagyendocytosisreformationcancerBORC |
| spellingShingle | Nadia Bouhamdani Nadia Bouhamdani Nadia Bouhamdani Dominique Comeau Dominique Comeau Sandra Turcotte Sandra Turcotte A Compendium of Information on the Lysosome Frontiers in Cell and Developmental Biology lysosome autophagy endocytosis reformation cancer BORC |
| title | A Compendium of Information on the Lysosome |
| title_full | A Compendium of Information on the Lysosome |
| title_fullStr | A Compendium of Information on the Lysosome |
| title_full_unstemmed | A Compendium of Information on the Lysosome |
| title_short | A Compendium of Information on the Lysosome |
| title_sort | compendium of information on the lysosome |
| topic | lysosome autophagy endocytosis reformation cancer BORC |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.798262/full |
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