Birth Weight, Postnatal Weight Gain, and Childhood Adiposity in Relation to Lipid Profile and Blood Pressure During Early Adolescence
BackgroundDifferent pathways likely underlie the association between early weight gain and cardiovascular disease risk. We examined whether birth weight for length relationship and weight gain up to 2 years of age are associated with lipid profiles and blood pressure (BP) in early adolescence and de...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-08-01
|
| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.117.006302 |
| _version_ | 1828858201313902592 |
|---|---|
| author | Andraea Van Hulst Tracie A. Barnett Gilles Paradis Marie‐Hélène Roy‐Gagnon Lilianne Gomez‐Lopez Mélanie Henderson |
| author_facet | Andraea Van Hulst Tracie A. Barnett Gilles Paradis Marie‐Hélène Roy‐Gagnon Lilianne Gomez‐Lopez Mélanie Henderson |
| author_sort | Andraea Van Hulst |
| collection | DOAJ |
| description | BackgroundDifferent pathways likely underlie the association between early weight gain and cardiovascular disease risk. We examined whether birth weight for length relationship and weight gain up to 2 years of age are associated with lipid profiles and blood pressure (BP) in early adolescence and determined whether childhood adiposity mediates these associations. Methods and ResultsData from QUALITY (Quebec Adipose and Lifestyle Investigation in Youth), a cohort of white children with parental history of obesity, were analyzed (n=395). Sex‐specific weight for length z scores from birth to 2 years were computed. Rate of postnatal weight gain was estimated using individual slopes of weight for length z‐score measurements. Percentage of body fat was measured at 8 to 10 years. Fasting lipids and BP were measured at 10 to 12 years. Using path analysis, we found indirect effects of postnatal weight gain, through childhood adiposity, on all outcomes: Rate of postnatal weight for length gain was positively associated with childhood adiposity, which in turn was associated with unfavorable lipid and BP levels in early adolescence. In contrast, small beneficial direct effects on diastolic BP z scores, independent of weight at other time points, were found for birth weight for length (β=−0.05, 95% CI, −0.09 to −0.002) and for postnatal weight gain (β=−0.02, 95% CI, −0.03 to −0.002). ConclusionsAmong children with at least 1 obese parent, faster postnatal weight gain leads to cardiovascular risk factors in early adolescence through its effect on childhood adiposity. Although heavier newborns may have lower BP in early adolescence, this protective direct effect could be offset by a deleterious indirect effect linking birth weight to later adiposity. |
| first_indexed | 2024-12-13T01:52:16Z |
| format | Article |
| id | doaj.art-988e554479c242cfa8addd671b522632 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-12-13T01:52:16Z |
| publishDate | 2017-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-988e554479c242cfa8addd671b5226322022-12-22T00:03:29ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802017-08-016810.1161/JAHA.117.006302Birth Weight, Postnatal Weight Gain, and Childhood Adiposity in Relation to Lipid Profile and Blood Pressure During Early AdolescenceAndraea Van Hulst0Tracie A. Barnett1Gilles Paradis2Marie‐Hélène Roy‐Gagnon3Lilianne Gomez‐Lopez4Mélanie Henderson5Department of Epidemiology Biostatistics and Occupational Health, McGill University, Montreal, CanadaCentre de recherche du CHU Sainte‐Justine, Montreal, CanadaDepartment of Epidemiology Biostatistics and Occupational Health, McGill University, Montreal, CanadaSchool of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, CanadaCentre de recherche du CHU Sainte‐Justine, Montreal, CanadaCentre de recherche du CHU Sainte‐Justine, Montreal, CanadaBackgroundDifferent pathways likely underlie the association between early weight gain and cardiovascular disease risk. We examined whether birth weight for length relationship and weight gain up to 2 years of age are associated with lipid profiles and blood pressure (BP) in early adolescence and determined whether childhood adiposity mediates these associations. Methods and ResultsData from QUALITY (Quebec Adipose and Lifestyle Investigation in Youth), a cohort of white children with parental history of obesity, were analyzed (n=395). Sex‐specific weight for length z scores from birth to 2 years were computed. Rate of postnatal weight gain was estimated using individual slopes of weight for length z‐score measurements. Percentage of body fat was measured at 8 to 10 years. Fasting lipids and BP were measured at 10 to 12 years. Using path analysis, we found indirect effects of postnatal weight gain, through childhood adiposity, on all outcomes: Rate of postnatal weight for length gain was positively associated with childhood adiposity, which in turn was associated with unfavorable lipid and BP levels in early adolescence. In contrast, small beneficial direct effects on diastolic BP z scores, independent of weight at other time points, were found for birth weight for length (β=−0.05, 95% CI, −0.09 to −0.002) and for postnatal weight gain (β=−0.02, 95% CI, −0.03 to −0.002). ConclusionsAmong children with at least 1 obese parent, faster postnatal weight gain leads to cardiovascular risk factors in early adolescence through its effect on childhood adiposity. Although heavier newborns may have lower BP in early adolescence, this protective direct effect could be offset by a deleterious indirect effect linking birth weight to later adiposity.https://www.ahajournals.org/doi/10.1161/JAHA.117.006302birth weightblood pressurelipid profileobesitypostnatal weight gain |
| spellingShingle | Andraea Van Hulst Tracie A. Barnett Gilles Paradis Marie‐Hélène Roy‐Gagnon Lilianne Gomez‐Lopez Mélanie Henderson Birth Weight, Postnatal Weight Gain, and Childhood Adiposity in Relation to Lipid Profile and Blood Pressure During Early Adolescence Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease birth weight blood pressure lipid profile obesity postnatal weight gain |
| title | Birth Weight, Postnatal Weight Gain, and Childhood Adiposity in Relation to Lipid Profile and Blood Pressure During Early Adolescence |
| title_full | Birth Weight, Postnatal Weight Gain, and Childhood Adiposity in Relation to Lipid Profile and Blood Pressure During Early Adolescence |
| title_fullStr | Birth Weight, Postnatal Weight Gain, and Childhood Adiposity in Relation to Lipid Profile and Blood Pressure During Early Adolescence |
| title_full_unstemmed | Birth Weight, Postnatal Weight Gain, and Childhood Adiposity in Relation to Lipid Profile and Blood Pressure During Early Adolescence |
| title_short | Birth Weight, Postnatal Weight Gain, and Childhood Adiposity in Relation to Lipid Profile and Blood Pressure During Early Adolescence |
| title_sort | birth weight postnatal weight gain and childhood adiposity in relation to lipid profile and blood pressure during early adolescence |
| topic | birth weight blood pressure lipid profile obesity postnatal weight gain |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.117.006302 |
| work_keys_str_mv | AT andraeavanhulst birthweightpostnatalweightgainandchildhoodadiposityinrelationtolipidprofileandbloodpressureduringearlyadolescence AT tracieabarnett birthweightpostnatalweightgainandchildhoodadiposityinrelationtolipidprofileandbloodpressureduringearlyadolescence AT gillesparadis birthweightpostnatalweightgainandchildhoodadiposityinrelationtolipidprofileandbloodpressureduringearlyadolescence AT marieheleneroygagnon birthweightpostnatalweightgainandchildhoodadiposityinrelationtolipidprofileandbloodpressureduringearlyadolescence AT liliannegomezlopez birthweightpostnatalweightgainandchildhoodadiposityinrelationtolipidprofileandbloodpressureduringearlyadolescence AT melaniehenderson birthweightpostnatalweightgainandchildhoodadiposityinrelationtolipidprofileandbloodpressureduringearlyadolescence |