Overview of metabolomic markers used for diagnosing cardiovascular diseases
At present, metabolomics is an intensively developing approach to the specific diagnosis of cardiovascular diseases. Metabolic analysis allows the study of complete metabolomic profiles and their deviations resulting from changes, for example, gene and RNA expression, protein activity, or environmen...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Russian Academy of Sciences, Siberian Branch Publishing House
2022-02-01
|
| Series: | Сибирский научный медицинский журнал |
| Subjects: | |
| Online Access: | https://sibmed.elpub.ru/jour/article/view/719 |
| _version_ | 1797269543808139264 |
|---|---|
| author | O. V. Astafyeva Z. V. Zharkova A. L. Yasenyavskaya I. B. Nikitina I. V. Goretova I. V. Fedoseev O. A. Bashkina M. A. Samotrueva |
| author_facet | O. V. Astafyeva Z. V. Zharkova A. L. Yasenyavskaya I. B. Nikitina I. V. Goretova I. V. Fedoseev O. A. Bashkina M. A. Samotrueva |
| author_sort | O. V. Astafyeva |
| collection | DOAJ |
| description | At present, metabolomics is an intensively developing approach to the specific diagnosis of cardiovascular diseases. Metabolic analysis allows the study of complete metabolomic profiles and their deviations resulting from changes, for example, gene and RNA expression, protein activity, or environmental factors. Analysis of the metabolomic blood profile helps in solving a large number of scientific and clinical problems, one of which is the search for markers of diseases, in particular, cardiovascular diseases (CVD). Aim of the study was to investigate metabolomic markers used for the diagnosis of cardiovascular diseases on the basis of literature data. Material and methods. The literature data was analyzed for key words: cardiovascular diseases, metabolomics, metabolic profile, metabolomic markers in da- tabases PubMed, Scopus, Web of Science, CyberLeninka, PatentDB, Science Direct Open Access, eLibrary. Results. Analysis of literature data and patent search confirms the high importance of metabolomic markers in the diagnosis of CVD. In the patent literature, BNP/NT-proBNP is most common used as a metabolic marker of CVD (11.27 %). The use of CRP (8.99 %) and troponin (8.49 %) is also common. PICP (0.02 %), sVCAM-1 (0.09 %), stimulating growth factor ST-2 (0.12 %) and thrombomodulin (0.12 %) as metabolic markers of CVD. Conclusions. Against the backdrop of analytical methods, metabolomics is the most important diagnostic area. At the same time, it should be noted that by combining the results of the analysis of metabolic studies with others, for example, genomic and proteomic, one can get a complete picture of the pathogenesis of diseases, assess the risk of complications, and also determine the effectiveness of the treatment. |
| first_indexed | 2024-03-08T14:33:10Z |
| format | Article |
| id | doaj.art-988e80606cf2409e9e88fc60f3bde580 |
| institution | Directory Open Access Journal |
| issn | 2410-2512 2410-2520 |
| language | Russian |
| last_indexed | 2024-04-25T01:50:03Z |
| publishDate | 2022-02-01 |
| publisher | Russian Academy of Sciences, Siberian Branch Publishing House |
| record_format | Article |
| series | Сибирский научный медицинский журнал |
| spelling | doaj.art-988e80606cf2409e9e88fc60f3bde5802024-03-07T18:50:00ZrusRussian Academy of Sciences, Siberian Branch Publishing HouseСибирский научный медицинский журнал2410-25122410-25202022-02-01421132910.18699/SSMJ20220102402Overview of metabolomic markers used for diagnosing cardiovascular diseasesO. V. Astafyeva0Z. V. Zharkova1A. L. Yasenyavskaya2I. B. Nikitina3I. V. Goretova4I. V. Fedoseev5O. A. Bashkina6M. A. Samotrueva7Astrakhan State Medical University of Minzdrav of RussiaAstrakhan State Medical University of Minzdrav of RussiaAstrakhan State Medical University of Minzdrav of RussiaFederal Institute of Industrial Property of Federal Service for Intellectual PropertyFederal Institute of Industrial Property of Federal Service for Intellectual PropertyFederal Institute of Industrial Property of Federal Service for Intellectual PropertyAstrakhan State Medical University of Minzdrav of RussiaAstrakhan State Medical University of Minzdrav of RussiaAt present, metabolomics is an intensively developing approach to the specific diagnosis of cardiovascular diseases. Metabolic analysis allows the study of complete metabolomic profiles and their deviations resulting from changes, for example, gene and RNA expression, protein activity, or environmental factors. Analysis of the metabolomic blood profile helps in solving a large number of scientific and clinical problems, one of which is the search for markers of diseases, in particular, cardiovascular diseases (CVD). Aim of the study was to investigate metabolomic markers used for the diagnosis of cardiovascular diseases on the basis of literature data. Material and methods. The literature data was analyzed for key words: cardiovascular diseases, metabolomics, metabolic profile, metabolomic markers in da- tabases PubMed, Scopus, Web of Science, CyberLeninka, PatentDB, Science Direct Open Access, eLibrary. Results. Analysis of literature data and patent search confirms the high importance of metabolomic markers in the diagnosis of CVD. In the patent literature, BNP/NT-proBNP is most common used as a metabolic marker of CVD (11.27 %). The use of CRP (8.99 %) and troponin (8.49 %) is also common. PICP (0.02 %), sVCAM-1 (0.09 %), stimulating growth factor ST-2 (0.12 %) and thrombomodulin (0.12 %) as metabolic markers of CVD. Conclusions. Against the backdrop of analytical methods, metabolomics is the most important diagnostic area. At the same time, it should be noted that by combining the results of the analysis of metabolic studies with others, for example, genomic and proteomic, one can get a complete picture of the pathogenesis of diseases, assess the risk of complications, and also determine the effectiveness of the treatment.https://sibmed.elpub.ru/jour/article/view/719cardiovascular diseasesmetabolomicsmetabolomic profilemetabolomic markers. |
| spellingShingle | O. V. Astafyeva Z. V. Zharkova A. L. Yasenyavskaya I. B. Nikitina I. V. Goretova I. V. Fedoseev O. A. Bashkina M. A. Samotrueva Overview of metabolomic markers used for diagnosing cardiovascular diseases Сибирский научный медицинский журнал cardiovascular diseases metabolomics metabolomic profile metabolomic markers. |
| title | Overview of metabolomic markers used for diagnosing cardiovascular diseases |
| title_full | Overview of metabolomic markers used for diagnosing cardiovascular diseases |
| title_fullStr | Overview of metabolomic markers used for diagnosing cardiovascular diseases |
| title_full_unstemmed | Overview of metabolomic markers used for diagnosing cardiovascular diseases |
| title_short | Overview of metabolomic markers used for diagnosing cardiovascular diseases |
| title_sort | overview of metabolomic markers used for diagnosing cardiovascular diseases |
| topic | cardiovascular diseases metabolomics metabolomic profile metabolomic markers. |
| url | https://sibmed.elpub.ru/jour/article/view/719 |
| work_keys_str_mv | AT ovastafyeva overviewofmetabolomicmarkersusedfordiagnosingcardiovasculardiseases AT zvzharkova overviewofmetabolomicmarkersusedfordiagnosingcardiovasculardiseases AT alyasenyavskaya overviewofmetabolomicmarkersusedfordiagnosingcardiovasculardiseases AT ibnikitina overviewofmetabolomicmarkersusedfordiagnosingcardiovasculardiseases AT ivgoretova overviewofmetabolomicmarkersusedfordiagnosingcardiovasculardiseases AT ivfedoseev overviewofmetabolomicmarkersusedfordiagnosingcardiovasculardiseases AT oabashkina overviewofmetabolomicmarkersusedfordiagnosingcardiovasculardiseases AT masamotrueva overviewofmetabolomicmarkersusedfordiagnosingcardiovasculardiseases |