A Novel Method to Determine the Cause of Left Internal Mammary Artery Instant Non-Patency Based on Transit Time Flow Measurement
Objective: After coronary artery bypass grafting (CABG) surgery, the main causes of poor instant patency of left internal mammary arteries (LIMAs) are competitive flow and anastomotic stenosis, but how to determine the cause of LIMA non-patency without interfering with the native coronary artery is...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.901280/full |
| _version_ | 1811329974119956480 |
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| author | Boyan Mao Yue Feng Yue Feng Mengyao Duan Yihang Dong Gaoyang Li Bao Li Jincheng Liu Yuting Guo Minghui Wei Zhou Zhao Youjun Liu |
| author_facet | Boyan Mao Yue Feng Yue Feng Mengyao Duan Yihang Dong Gaoyang Li Bao Li Jincheng Liu Yuting Guo Minghui Wei Zhou Zhao Youjun Liu |
| author_sort | Boyan Mao |
| collection | DOAJ |
| description | Objective: After coronary artery bypass grafting (CABG) surgery, the main causes of poor instant patency of left internal mammary arteries (LIMAs) are competitive flow and anastomotic stenosis, but how to determine the cause of LIMA non-patency without interfering with the native coronary artery is still a difficult problem to be solved urgently.Methods: In this study, a 0D-3D coupled multiscaled CABG model of anastomotic stenosis and competitive flow was constructed. After calculation, the flow waveform of the LIMA was extracted, and the waveform shape, common clinical parameters (average flow, PI, and DF), and graft flow FFT ratio results (F0/H1 and F0/H2) were analyzed.Results: For LIMA, these three common clinical parameters did not differ significantly between the anastomotic stenosis group and competitive flow group. However, the waveform shape and FFT ratio (especially F0/H2) of the competitive flow group were significantly different from those of the anastomotic stenosis group. When the cause was competitive flow, there was systolic backflow, and F0/H2 was too high (>14.89). When the cause was anastomotic stenosis, the waveform maintained a bimodal state and F0/H2 was in a normal state (about 1.17).Conclusion: When poor instant patency of the LIMA is found after CABG, the causes can be determined by graft flow waveform shape and F0/H2. |
| first_indexed | 2024-04-13T15:54:20Z |
| format | Article |
| id | doaj.art-988f6da6751d417eaed202d7f7e7a440 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-13T15:54:20Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-988f6da6751d417eaed202d7f7e7a4402022-12-22T02:40:46ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-06-011310.3389/fphys.2022.901280901280A Novel Method to Determine the Cause of Left Internal Mammary Artery Instant Non-Patency Based on Transit Time Flow MeasurementBoyan Mao0Yue Feng1Yue Feng2Mengyao Duan3Yihang Dong4Gaoyang Li5Bao Li6Jincheng Liu7Yuting Guo8Minghui Wei9Zhou Zhao10Youjun Liu11School of Life Sciences, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Biomedical Engineering, Faculty of Environment and Life, Beijing University of Technology, Beijing, ChinaMedical Equipment Department, Peking University First Hospital, Beijing, ChinaSchool of Life Sciences, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Life Sciences, Beijing University of Chinese Medicine, Beijing, ChinaInstitute of Fluid Science, Tohoku University, Sendai, JapanDepartment of Biomedical Engineering, Faculty of Environment and Life, Beijing University of Technology, Beijing, ChinaDepartment of Biomedical Engineering, Faculty of Environment and Life, Beijing University of Technology, Beijing, ChinaInstitute of Fluid Science, Tohoku University, Sendai, JapanSchool of Life Sciences, Beijing University of Chinese Medicine, Beijing, ChinaCardiac Surgery Department, Peking University People’s Hospital, Beijing, ChinaDepartment of Biomedical Engineering, Faculty of Environment and Life, Beijing University of Technology, Beijing, ChinaObjective: After coronary artery bypass grafting (CABG) surgery, the main causes of poor instant patency of left internal mammary arteries (LIMAs) are competitive flow and anastomotic stenosis, but how to determine the cause of LIMA non-patency without interfering with the native coronary artery is still a difficult problem to be solved urgently.Methods: In this study, a 0D-3D coupled multiscaled CABG model of anastomotic stenosis and competitive flow was constructed. After calculation, the flow waveform of the LIMA was extracted, and the waveform shape, common clinical parameters (average flow, PI, and DF), and graft flow FFT ratio results (F0/H1 and F0/H2) were analyzed.Results: For LIMA, these three common clinical parameters did not differ significantly between the anastomotic stenosis group and competitive flow group. However, the waveform shape and FFT ratio (especially F0/H2) of the competitive flow group were significantly different from those of the anastomotic stenosis group. When the cause was competitive flow, there was systolic backflow, and F0/H2 was too high (>14.89). When the cause was anastomotic stenosis, the waveform maintained a bimodal state and F0/H2 was in a normal state (about 1.17).Conclusion: When poor instant patency of the LIMA is found after CABG, the causes can be determined by graft flow waveform shape and F0/H2.https://www.frontiersin.org/articles/10.3389/fphys.2022.901280/fullcomputational fluid dynamicsmultiscaled modelcoronary artery bypass graftinggraft patencylumped parameter model |
| spellingShingle | Boyan Mao Yue Feng Yue Feng Mengyao Duan Yihang Dong Gaoyang Li Bao Li Jincheng Liu Yuting Guo Minghui Wei Zhou Zhao Youjun Liu A Novel Method to Determine the Cause of Left Internal Mammary Artery Instant Non-Patency Based on Transit Time Flow Measurement Frontiers in Physiology computational fluid dynamics multiscaled model coronary artery bypass grafting graft patency lumped parameter model |
| title | A Novel Method to Determine the Cause of Left Internal Mammary Artery Instant Non-Patency Based on Transit Time Flow Measurement |
| title_full | A Novel Method to Determine the Cause of Left Internal Mammary Artery Instant Non-Patency Based on Transit Time Flow Measurement |
| title_fullStr | A Novel Method to Determine the Cause of Left Internal Mammary Artery Instant Non-Patency Based on Transit Time Flow Measurement |
| title_full_unstemmed | A Novel Method to Determine the Cause of Left Internal Mammary Artery Instant Non-Patency Based on Transit Time Flow Measurement |
| title_short | A Novel Method to Determine the Cause of Left Internal Mammary Artery Instant Non-Patency Based on Transit Time Flow Measurement |
| title_sort | novel method to determine the cause of left internal mammary artery instant non patency based on transit time flow measurement |
| topic | computational fluid dynamics multiscaled model coronary artery bypass grafting graft patency lumped parameter model |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2022.901280/full |
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