Leveraging Quantitative Systems Pharmacology Approach into Development of Human Recombinant Follistatin Fusion Protein for Duchenne Muscular Dystrophy

Leveraging Quantitative Systems Pharmacology Approach into Development of Human Recombinant Follistatin Fusion Protein for Duchenne Muscular Dystrophy

Quantitative understanding about the dynamics of drug–target interactions in biological systems is essential, especially in rare disease programs with small patient populations. Follistatin, by antagonism of myostatin and activin, which are negative regulators of skeletal muscle and inflammatory res...

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Bibliographic Details
Main Authors: Hoa Q. Nguyen, Andrea Iskenderian, David Ehmann, Paul Jasper, Zhiwei Zhang, Haojing Rong, Devin Welty, Rangaraj Narayanan
Format: Article
Language:English
Published: Wiley 2020-06-01
Series:CPT: Pharmacometrics & Systems Pharmacology
Online Access:https://doi.org/10.1002/psp4.12518

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