Clinicopathologic characteristics of early-onset colorectal cancer
Purpose The aim of this study was to analysis of the clinicopathological characteristics and prognosis of colorectal cancer (CRC) under the age of 50 years. Methods Between January 2009 and December 2018, 1,126 primary CRC patients were included from National Health Insurance Service Ilsan Hospital....
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Society of Coloproctology
2022-10-01
|
| Series: | Annals of Coloproctology |
| Subjects: | |
| Online Access: | http://coloproctol.org/upload/pdf/ac-2021-00976-0139.pdf |
| _version_ | 1811179560319844352 |
|---|---|
| author | Kui Seon Park Young Ki Hong Yoon Jung Choi Jung Gu Kang |
| author_facet | Kui Seon Park Young Ki Hong Yoon Jung Choi Jung Gu Kang |
| author_sort | Kui Seon Park |
| collection | DOAJ |
| description | Purpose The aim of this study was to analysis of the clinicopathological characteristics and prognosis of colorectal cancer (CRC) under the age of 50 years. Methods Between January 2009 and December 2018, 1,126 primary CRC patients were included from National Health Insurance Service Ilsan Hospital. The patients were divided into group 1 (n=111, ≤50 years) and group 2 (n=1,015, >50 years). The clinicopathologic features and prognostic outcomes were compared. In addition, to analyze whether there were any differences of those characteristics in 3 groups, patients aged under 50 years were divided into their 20s, 30s, and 40s. Results Group 1 had a slightly higher distribution in the left colon and rectum, lower T stage I and higher T stage IV rate, and a significantly higher distribution in stage N2 than group 2 (30.6%:16.3%, P<0.001). Poor histological differentiation of tumors was significantly high in group 1 (P=0.003). The 5-year survival rate for those in their 30s (69.2%) and 40s (91.6%) was higher than those in their 20s who died immediately after surgery (P<0.001). The 5-year disease-free survival rate was also confirmed to be meaningful for each age group, with 0% in their 20s, 53.8% in their 30s, 79.2% in their 40s (P<0.001). Conclusion Although the age was not an independent prognostic factor for overall survival in this study, the early onset group of CRCs is more advanced at the time of diagnosis and has a more aggressive histologic type. |
| first_indexed | 2024-04-11T06:36:22Z |
| format | Article |
| id | doaj.art-9890f7cbfe0348c69e6427497f4787b4 |
| institution | Directory Open Access Journal |
| issn | 2287-9714 2287-9722 |
| language | English |
| last_indexed | 2024-04-11T06:36:22Z |
| publishDate | 2022-10-01 |
| publisher | Korean Society of Coloproctology |
| record_format | Article |
| series | Annals of Coloproctology |
| spelling | doaj.art-9890f7cbfe0348c69e6427497f4787b42022-12-22T04:39:41ZengKorean Society of ColoproctologyAnnals of Coloproctology2287-97142287-97222022-10-0138536236910.3393/ac.2021.00976.01391916Clinicopathologic characteristics of early-onset colorectal cancerKui Seon Park0Young Ki Hong1Yoon Jung Choi2Jung Gu Kang3 Department of Surgery, CHA Ilsan Medical Center, CHA University, Goyang, Korea Department of Surgery, National Health Insurance Service Ilsan Hospital, Goyang, Korea Department of Pathology, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea Department of Surgery, CHA Ilsan Medical Center, CHA University, Goyang, KoreaPurpose The aim of this study was to analysis of the clinicopathological characteristics and prognosis of colorectal cancer (CRC) under the age of 50 years. Methods Between January 2009 and December 2018, 1,126 primary CRC patients were included from National Health Insurance Service Ilsan Hospital. The patients were divided into group 1 (n=111, ≤50 years) and group 2 (n=1,015, >50 years). The clinicopathologic features and prognostic outcomes were compared. In addition, to analyze whether there were any differences of those characteristics in 3 groups, patients aged under 50 years were divided into their 20s, 30s, and 40s. Results Group 1 had a slightly higher distribution in the left colon and rectum, lower T stage I and higher T stage IV rate, and a significantly higher distribution in stage N2 than group 2 (30.6%:16.3%, P<0.001). Poor histological differentiation of tumors was significantly high in group 1 (P=0.003). The 5-year survival rate for those in their 30s (69.2%) and 40s (91.6%) was higher than those in their 20s who died immediately after surgery (P<0.001). The 5-year disease-free survival rate was also confirmed to be meaningful for each age group, with 0% in their 20s, 53.8% in their 30s, 79.2% in their 40s (P<0.001). Conclusion Although the age was not an independent prognostic factor for overall survival in this study, the early onset group of CRCs is more advanced at the time of diagnosis and has a more aggressive histologic type.http://coloproctol.org/upload/pdf/ac-2021-00976-0139.pdfcolorectal cancerprognosisscreeningyoung adult |
| spellingShingle | Kui Seon Park Young Ki Hong Yoon Jung Choi Jung Gu Kang Clinicopathologic characteristics of early-onset colorectal cancer Annals of Coloproctology colorectal cancer prognosis screening young adult |
| title | Clinicopathologic characteristics of early-onset colorectal cancer |
| title_full | Clinicopathologic characteristics of early-onset colorectal cancer |
| title_fullStr | Clinicopathologic characteristics of early-onset colorectal cancer |
| title_full_unstemmed | Clinicopathologic characteristics of early-onset colorectal cancer |
| title_short | Clinicopathologic characteristics of early-onset colorectal cancer |
| title_sort | clinicopathologic characteristics of early onset colorectal cancer |
| topic | colorectal cancer prognosis screening young adult |
| url | http://coloproctol.org/upload/pdf/ac-2021-00976-0139.pdf |
| work_keys_str_mv | AT kuiseonpark clinicopathologiccharacteristicsofearlyonsetcolorectalcancer AT youngkihong clinicopathologiccharacteristicsofearlyonsetcolorectalcancer AT yoonjungchoi clinicopathologiccharacteristicsofearlyonsetcolorectalcancer AT junggukang clinicopathologiccharacteristicsofearlyonsetcolorectalcancer |