HAT therapy for sepsis: A review of the therapeutic rationale and current clinical evaluation status
Vitamin C-based cluster therapy, which involves the combined application of hydrocortisone, vitamin C, and thiamine (HAT), is a recently proposed new treatment option for sepsis on top of conventional treatment. This therapy has a strong theoretical basis, but its clinical efficacy remains inconclus...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Journal of Intensive Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667100X23000294 |
| _version_ | 1797640281909100544 |
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| author | Yali Sun Yongfang Yang Zhuoyi Ye Tongwen Sun |
| author_facet | Yali Sun Yongfang Yang Zhuoyi Ye Tongwen Sun |
| author_sort | Yali Sun |
| collection | DOAJ |
| description | Vitamin C-based cluster therapy, which involves the combined application of hydrocortisone, vitamin C, and thiamine (HAT), is a recently proposed new treatment option for sepsis on top of conventional treatment. This therapy has a strong theoretical basis, but its clinical efficacy remains inconclusive. This review summarizes the rationale for HAT therapy for sepsis and describes the evaluation of its efficacy in clinical observational studies and randomized controlled trials, with the aim of providing a reference for the future clinical practice application of HAT therapy in sepsis. |
| first_indexed | 2024-03-11T13:28:42Z |
| format | Article |
| id | doaj.art-9894f6f7a872428cb3850e5e23ee19a7 |
| institution | Directory Open Access Journal |
| issn | 2667-100X |
| language | English |
| last_indexed | 2024-03-11T13:28:42Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Intensive Medicine |
| spelling | doaj.art-9894f6f7a872428cb3850e5e23ee19a72023-11-03T04:15:15ZengElsevierJournal of Intensive Medicine2667-100X2023-10-0134320325HAT therapy for sepsis: A review of the therapeutic rationale and current clinical evaluation statusYali Sun0Yongfang Yang1Zhuoyi Ye2Tongwen Sun3Department of General ICU, The First Affiliated Hospital of Zhengzhou University, Henan Key Laboratory of Critical Care Medicine, Zhengzhou Key Laboratory of Sepsis, Zhengzhou 450052, Henan, China; Henan Engineering Research Center for Critical Care Medicine, Department of General ICU, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, ChinaHenan Engineering Research Center for Critical Care Medicine, Department of General ICU, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, ChinaHenan Engineering Research Center for Critical Care Medicine, Department of General ICU, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, ChinaDepartment of General ICU, The First Affiliated Hospital of Zhengzhou University, Henan Key Laboratory of Critical Care Medicine, Zhengzhou Key Laboratory of Sepsis, Zhengzhou 450052, Henan, China; Henan Engineering Research Center for Critical Care Medicine, Department of General ICU, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China; Corresponding author: Tongwen Sun, Department of General ICU, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China.Vitamin C-based cluster therapy, which involves the combined application of hydrocortisone, vitamin C, and thiamine (HAT), is a recently proposed new treatment option for sepsis on top of conventional treatment. This therapy has a strong theoretical basis, but its clinical efficacy remains inconclusive. This review summarizes the rationale for HAT therapy for sepsis and describes the evaluation of its efficacy in clinical observational studies and randomized controlled trials, with the aim of providing a reference for the future clinical practice application of HAT therapy in sepsis.http://www.sciencedirect.com/science/article/pii/S2667100X23000294SepsisHAT therapyHydrocortisoneVitamin CThiamineMetabolic resuscitation |
| spellingShingle | Yali Sun Yongfang Yang Zhuoyi Ye Tongwen Sun HAT therapy for sepsis: A review of the therapeutic rationale and current clinical evaluation status Journal of Intensive Medicine Sepsis HAT therapy Hydrocortisone Vitamin C Thiamine Metabolic resuscitation |
| title | HAT therapy for sepsis: A review of the therapeutic rationale and current clinical evaluation status |
| title_full | HAT therapy for sepsis: A review of the therapeutic rationale and current clinical evaluation status |
| title_fullStr | HAT therapy for sepsis: A review of the therapeutic rationale and current clinical evaluation status |
| title_full_unstemmed | HAT therapy for sepsis: A review of the therapeutic rationale and current clinical evaluation status |
| title_short | HAT therapy for sepsis: A review of the therapeutic rationale and current clinical evaluation status |
| title_sort | hat therapy for sepsis a review of the therapeutic rationale and current clinical evaluation status |
| topic | Sepsis HAT therapy Hydrocortisone Vitamin C Thiamine Metabolic resuscitation |
| url | http://www.sciencedirect.com/science/article/pii/S2667100X23000294 |
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