Epigenetics and environment in breast cancer: New paradigms for anti-cancer therapies
Breast cancer remains the most frequently diagnosed cancer in women worldwide. Delayed presentation of the disease, late stage at diagnosis, limited therapeutic options, metastasis, and relapse are the major factors contributing to breast cancer mortality. The development and progression of breast c...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.971288/full |
| _version_ | 1828410470764118016 |
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| author | Chitra Thakur Chitra Thakur Yiran Qiu Yao Fu Zhuoyue Bi Wenxuan Zhang Haoyan Ji Fei Chen Fei Chen |
| author_facet | Chitra Thakur Chitra Thakur Yiran Qiu Yao Fu Zhuoyue Bi Wenxuan Zhang Haoyan Ji Fei Chen Fei Chen |
| author_sort | Chitra Thakur |
| collection | DOAJ |
| description | Breast cancer remains the most frequently diagnosed cancer in women worldwide. Delayed presentation of the disease, late stage at diagnosis, limited therapeutic options, metastasis, and relapse are the major factors contributing to breast cancer mortality. The development and progression of breast cancer is a complex and multi-step process that incorporates an accumulation of several genetic and epigenetic alterations. External environmental factors and internal cellular microenvironmental cues influence the occurrence of these alterations that drives tumorigenesis. Here, we discuss state-of-the-art information on the epigenetics of breast cancer and how environmental risk factors orchestrate major epigenetic events, emphasizing the necessity for a multidisciplinary approach toward a better understanding of the gene-environment interactions implicated in breast cancer. Since epigenetic modifications are reversible and are susceptible to extrinsic and intrinsic stimuli, they offer potential avenues that can be targeted for designing robust breast cancer therapies. |
| first_indexed | 2024-12-10T12:12:02Z |
| format | Article |
| id | doaj.art-989518dbeb934ad3ab67485732bc5786 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-10T12:12:02Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-989518dbeb934ad3ab67485732bc57862022-12-22T01:49:20ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-09-011210.3389/fonc.2022.971288971288Epigenetics and environment in breast cancer: New paradigms for anti-cancer therapiesChitra Thakur0Chitra Thakur1Yiran Qiu2Yao Fu3Zhuoyue Bi4Wenxuan Zhang5Haoyan Ji6Fei Chen7Fei Chen8Department of Pathology, Stony Brook Cancer Center, Stony Brook, NY, United StatesDepartment of Pathology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, United StatesDepartment of Pathology, Stony Brook Cancer Center, Stony Brook, NY, United StatesDepartment of Pathology, Stony Brook Cancer Center, Stony Brook, NY, United StatesDepartment of Pathology, Stony Brook Cancer Center, Stony Brook, NY, United StatesDepartment of Pathology, Stony Brook Cancer Center, Stony Brook, NY, United StatesDepartment of Pathology, Stony Brook Cancer Center, Stony Brook, NY, United StatesDepartment of Pathology, Stony Brook Cancer Center, Stony Brook, NY, United StatesDepartment of Pathology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, United StatesBreast cancer remains the most frequently diagnosed cancer in women worldwide. Delayed presentation of the disease, late stage at diagnosis, limited therapeutic options, metastasis, and relapse are the major factors contributing to breast cancer mortality. The development and progression of breast cancer is a complex and multi-step process that incorporates an accumulation of several genetic and epigenetic alterations. External environmental factors and internal cellular microenvironmental cues influence the occurrence of these alterations that drives tumorigenesis. Here, we discuss state-of-the-art information on the epigenetics of breast cancer and how environmental risk factors orchestrate major epigenetic events, emphasizing the necessity for a multidisciplinary approach toward a better understanding of the gene-environment interactions implicated in breast cancer. Since epigenetic modifications are reversible and are susceptible to extrinsic and intrinsic stimuli, they offer potential avenues that can be targeted for designing robust breast cancer therapies.https://www.frontiersin.org/articles/10.3389/fonc.2022.971288/fullbreast cancerepigeneticsDNA methylationchromatin modificationmetabolismenvironment |
| spellingShingle | Chitra Thakur Chitra Thakur Yiran Qiu Yao Fu Zhuoyue Bi Wenxuan Zhang Haoyan Ji Fei Chen Fei Chen Epigenetics and environment in breast cancer: New paradigms for anti-cancer therapies Frontiers in Oncology breast cancer epigenetics DNA methylation chromatin modification metabolism environment |
| title | Epigenetics and environment in breast cancer: New paradigms for anti-cancer therapies |
| title_full | Epigenetics and environment in breast cancer: New paradigms for anti-cancer therapies |
| title_fullStr | Epigenetics and environment in breast cancer: New paradigms for anti-cancer therapies |
| title_full_unstemmed | Epigenetics and environment in breast cancer: New paradigms for anti-cancer therapies |
| title_short | Epigenetics and environment in breast cancer: New paradigms for anti-cancer therapies |
| title_sort | epigenetics and environment in breast cancer new paradigms for anti cancer therapies |
| topic | breast cancer epigenetics DNA methylation chromatin modification metabolism environment |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.971288/full |
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