Thin bronchoscopic cryobiopsy using a nasobronchial tube
Abstract Background Transbronchial lung cryobiopsy is useful when diagnosing lung lesions. However, prevention of associated bleeding complications is essential. This study aimed to evaluate the safety and efficacy of our novel bronchoscopic cryobiopsy technique, which uses a long nasobronchial tube...
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| Format: | Article |
| Language: | English |
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BMC
2022-09-01
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| Series: | BMC Pulmonary Medicine |
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| Online Access: | https://doi.org/10.1186/s12890-022-02166-w |
| _version_ | 1828111754126688256 |
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| author | Masahide Oki Hideo Saka Yoshihito Kogure Hideyuki Niwa Akane Ishida Arisa Yamada Atsushi Torii Chiyoe Kitagawa |
| author_facet | Masahide Oki Hideo Saka Yoshihito Kogure Hideyuki Niwa Akane Ishida Arisa Yamada Atsushi Torii Chiyoe Kitagawa |
| author_sort | Masahide Oki |
| collection | DOAJ |
| description | Abstract Background Transbronchial lung cryobiopsy is useful when diagnosing lung lesions. However, prevention of associated bleeding complications is essential. This study aimed to evaluate the safety and efficacy of our novel bronchoscopic cryobiopsy technique, which uses a long nasobronchial tube to prevent blood flooding the central airway. Methods Patients with localized or diffuse lung lesions were prospectively enrolled and underwent cryobiopsy using a 1.9 mm diameter cryoprobe and a 4.0 mm diameter thin bronchoscope under conscious sedation. For cryobiopsy, a long silicone tube (inner diameter, 5.0 mm) was advanced through the nose to the target bronchus, then wedged to drain blood under thin-tube bronchoscopic control. The primary endpoint was the frequency of bleeding complications. Results Of the 80 patients initially enrolled, 73 that underwent at least one cryobiopsy were ultimately included. Mild bleeding during cryobiopsy occurred in 58 patients (79.5%), but there was no moderate or severe bleeding. Other complications occurred in four patients (two pneumothorax, one pneumomediastinum, and one pneumonia). Tube dislocation was noted in eight patients (11%). Cryobiopsy specimens were significantly larger than forceps biopsy specimens (9.0 mm2 vs. 2.7 mm2, P < .001) and allowed specific diagnoses in 50 patients (68.5%). Conclusions Thin bronchoscopic cryobiopsy using a nasobronchial tube in consciously sedated patients is safe and effective. Trial registration Date of registration: 24/06/2019. UMIN-Clinical Trials Registry; Identifier: UMIN000037156 https://www.umin.ac.jp/ctr/index.htm |
| first_indexed | 2024-04-11T11:39:14Z |
| format | Article |
| id | doaj.art-989544f9f5b744a2a90a776624b07480 |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-04-11T11:39:14Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-989544f9f5b744a2a90a776624b074802022-12-22T04:25:52ZengBMCBMC Pulmonary Medicine1471-24662022-09-012211810.1186/s12890-022-02166-wThin bronchoscopic cryobiopsy using a nasobronchial tubeMasahide Oki0Hideo Saka1Yoshihito Kogure2Hideyuki Niwa3Akane Ishida4Arisa Yamada5Atsushi Torii6Chiyoe Kitagawa7Department of Respiratory Medicine, National Hospital Organization Nagoya Medical CenterDepartment of Respiratory Medicine, National Hospital Organization Nagoya Medical CenterDepartment of Respiratory Medicine, National Hospital Organization Nagoya Medical CenterDepartment of Respiratory Medicine, National Hospital Organization Nagoya Medical CenterDepartment of Respiratory Medicine, National Hospital Organization Nagoya Medical CenterDepartment of Respiratory Medicine, National Hospital Organization Nagoya Medical CenterDepartment of Respiratory Medicine, National Hospital Organization Nagoya Medical CenterDepartment of Respiratory Medicine, National Hospital Organization Nagoya Medical CenterAbstract Background Transbronchial lung cryobiopsy is useful when diagnosing lung lesions. However, prevention of associated bleeding complications is essential. This study aimed to evaluate the safety and efficacy of our novel bronchoscopic cryobiopsy technique, which uses a long nasobronchial tube to prevent blood flooding the central airway. Methods Patients with localized or diffuse lung lesions were prospectively enrolled and underwent cryobiopsy using a 1.9 mm diameter cryoprobe and a 4.0 mm diameter thin bronchoscope under conscious sedation. For cryobiopsy, a long silicone tube (inner diameter, 5.0 mm) was advanced through the nose to the target bronchus, then wedged to drain blood under thin-tube bronchoscopic control. The primary endpoint was the frequency of bleeding complications. Results Of the 80 patients initially enrolled, 73 that underwent at least one cryobiopsy were ultimately included. Mild bleeding during cryobiopsy occurred in 58 patients (79.5%), but there was no moderate or severe bleeding. Other complications occurred in four patients (two pneumothorax, one pneumomediastinum, and one pneumonia). Tube dislocation was noted in eight patients (11%). Cryobiopsy specimens were significantly larger than forceps biopsy specimens (9.0 mm2 vs. 2.7 mm2, P < .001) and allowed specific diagnoses in 50 patients (68.5%). Conclusions Thin bronchoscopic cryobiopsy using a nasobronchial tube in consciously sedated patients is safe and effective. Trial registration Date of registration: 24/06/2019. UMIN-Clinical Trials Registry; Identifier: UMIN000037156 https://www.umin.ac.jp/ctr/index.htmhttps://doi.org/10.1186/s12890-022-02166-wBleedingBronchoscopyComplicationsCryobiopsyThin bronchoscope |
| spellingShingle | Masahide Oki Hideo Saka Yoshihito Kogure Hideyuki Niwa Akane Ishida Arisa Yamada Atsushi Torii Chiyoe Kitagawa Thin bronchoscopic cryobiopsy using a nasobronchial tube BMC Pulmonary Medicine Bleeding Bronchoscopy Complications Cryobiopsy Thin bronchoscope |
| title | Thin bronchoscopic cryobiopsy using a nasobronchial tube |
| title_full | Thin bronchoscopic cryobiopsy using a nasobronchial tube |
| title_fullStr | Thin bronchoscopic cryobiopsy using a nasobronchial tube |
| title_full_unstemmed | Thin bronchoscopic cryobiopsy using a nasobronchial tube |
| title_short | Thin bronchoscopic cryobiopsy using a nasobronchial tube |
| title_sort | thin bronchoscopic cryobiopsy using a nasobronchial tube |
| topic | Bleeding Bronchoscopy Complications Cryobiopsy Thin bronchoscope |
| url | https://doi.org/10.1186/s12890-022-02166-w |
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