Derivatives of Isoindoline, Synthesis and Biological Activity. II. Biological Activity of Derivatives of Isoindoline
The derivatives of isoindolines show different biological activity in vitro and in vivo and it is hopeful that some of the compounds of this group will develop into new efficient drugs for different types of diseases in the future. They are present in many natural and synthetic, biologically active...
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| Format: | Article |
| Language: | English |
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Croatian Society of Chemical Engineers
2014-05-01
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| Series: | Kemija u Industriji |
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| Online Access: | http://pierre.fkit.hr/hdki/kui/vol63/broj5-6/183.pdf |
| _version_ | 1828468327430750208 |
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| author | Sović, I. Karminski-Zamola, G. |
| author_facet | Sović, I. Karminski-Zamola, G. |
| author_sort | Sović, I. |
| collection | DOAJ |
| description | The derivatives of isoindolines show different biological activity in vitro and in vivo and it is hopeful that some of the compounds of this group will develop into new efficient drugs for different types of diseases in the future. They are present in many natural and synthetic, biologically active compounds, which have been reported to possess psycho-stimulant, analgesic, anti-inflammatory, antipyretic, antihypertensive, antifungal, and antitumor properties. Metal complexes of isondoline derivatives act as inhibitors of protein kinase and catalase. Among different biological activity, isoindoline derivatives also show activity against tumor cells of leukemia and are active on colon, epidermal and ovarian cancer. They also inhibit a number of enzymes responsible for cancer cell reproduction, such as histone deacetylase, tyrosine kinase receptor, and vascular endothelial growth factor receptor (VEGF-R2). |
| first_indexed | 2024-12-11T04:20:49Z |
| format | Article |
| id | doaj.art-9896014824e84c349732fdfa75e2c2af |
| institution | Directory Open Access Journal |
| issn | 0022-9830 1334-9090 |
| language | English |
| last_indexed | 2024-12-11T04:20:49Z |
| publishDate | 2014-05-01 |
| publisher | Croatian Society of Chemical Engineers |
| record_format | Article |
| series | Kemija u Industriji |
| spelling | doaj.art-9896014824e84c349732fdfa75e2c2af2022-12-22T01:21:07ZengCroatian Society of Chemical EngineersKemija u Industriji0022-98301334-90902014-05-01635-618319110.15255/KUI.2013.005Derivatives of Isoindoline, Synthesis and Biological Activity. II. Biological Activity of Derivatives of IsoindolineSović, I.0Karminski-Zamola, G.1Department of Organic Chemistry Faculty of Chemical Engineering and Technology University of Zagreb Marulićev trg 20, 10 000 Zagreb CroatiaDepartment of Organic Chemistry Faculty of Chemical Engineering and Technology University of Zagreb Marulićev trg 20, 10 000 Zagreb CroatiaThe derivatives of isoindolines show different biological activity in vitro and in vivo and it is hopeful that some of the compounds of this group will develop into new efficient drugs for different types of diseases in the future. They are present in many natural and synthetic, biologically active compounds, which have been reported to possess psycho-stimulant, analgesic, anti-inflammatory, antipyretic, antihypertensive, antifungal, and antitumor properties. Metal complexes of isondoline derivatives act as inhibitors of protein kinase and catalase. Among different biological activity, isoindoline derivatives also show activity against tumor cells of leukemia and are active on colon, epidermal and ovarian cancer. They also inhibit a number of enzymes responsible for cancer cell reproduction, such as histone deacetylase, tyrosine kinase receptor, and vascular endothelial growth factor receptor (VEGF-R2).http://pierre.fkit.hr/hdki/kui/vol63/broj5-6/183.pdfBiological activity of isoindolinesantitumor activityinhibition of enzymes |
| spellingShingle | Sović, I. Karminski-Zamola, G. Derivatives of Isoindoline, Synthesis and Biological Activity. II. Biological Activity of Derivatives of Isoindoline Kemija u Industriji Biological activity of isoindolines antitumor activity inhibition of enzymes |
| title | Derivatives of Isoindoline, Synthesis and Biological Activity. II. Biological Activity of Derivatives of Isoindoline |
| title_full | Derivatives of Isoindoline, Synthesis and Biological Activity. II. Biological Activity of Derivatives of Isoindoline |
| title_fullStr | Derivatives of Isoindoline, Synthesis and Biological Activity. II. Biological Activity of Derivatives of Isoindoline |
| title_full_unstemmed | Derivatives of Isoindoline, Synthesis and Biological Activity. II. Biological Activity of Derivatives of Isoindoline |
| title_short | Derivatives of Isoindoline, Synthesis and Biological Activity. II. Biological Activity of Derivatives of Isoindoline |
| title_sort | derivatives of isoindoline synthesis and biological activity ii biological activity of derivatives of isoindoline |
| topic | Biological activity of isoindolines antitumor activity inhibition of enzymes |
| url | http://pierre.fkit.hr/hdki/kui/vol63/broj5-6/183.pdf |
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