Two Versatile Pencil Graphite–Polymer Sensor Electrodes Coupled with Potentiometry and Potentiometric Titration Methods: Profiling Determinations of Vitamin V in Tablets and Urine Samples
Herein, we developed a new pencil graphite ion-selective electrode strategy for the broadly used erectile dysfunction medication, sildenafil citrate (SC, vitamin V), for its automated potentiometry and potentiometric titration profiling in marketed tablets and human urine samples. The method was bas...
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MDPI AG
2022-11-01
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| Online Access: | https://www.mdpi.com/1424-8220/22/23/9128 |
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| author | Abeer M. E. Hassan Mohamed A. El Hamd Mahmoud H. El-Maghrabey Wael A. Mahdi Sultan Alshehri Hany A. Batakoushy |
| author_facet | Abeer M. E. Hassan Mohamed A. El Hamd Mahmoud H. El-Maghrabey Wael A. Mahdi Sultan Alshehri Hany A. Batakoushy |
| author_sort | Abeer M. E. Hassan |
| collection | DOAJ |
| description | Herein, we developed a new pencil graphite ion-selective electrode strategy for the broadly used erectile dysfunction medication, sildenafil citrate (SC, vitamin V), for its automated potentiometry and potentiometric titration profiling in marketed tablets and human urine samples. The method was based on ion-pair complexation between SC and sodium tetraphenylborate (Na-TPB) or phosphotungstic acid (PTA), embedded into a pencil-fabricated graphite sensor electrode coated with poly(vinyl chloride, PVC) matrix, which is pre-plasticized with two different pre-studied plasticizers. The modern fabricated electrodes have a proven fast near-Nernstian response for SC over the concentration range of 1.0 × 10<sup>−6</sup> to 1.0 × 10<sup>−2</sup> and 1.0 × 10<sup>−5</sup> to 1.0 × 10<sup>−2</sup> M, with LODs of 6.5 × 10<sup>−7</sup> and 5.5 × 10<sup>−6</sup> over a pH 3–6 for (SC-TPB)- and (SC-PTA)-based membrane sensors, of O-nitrophenyl octyl ether (O-NPOE) and dioctyl phthalate (DOP), respectively. The selectivity coefficients for different interferents, including many inorganic cations, sugars, and/or nitrogenous compounds, were tested and confirmed. Applications of the proposed method were conducted on the determination of SC in its tablets and urine samples under the proper conditions. The percent recovery values were compared with those obtained by an official method and showed an RSD ≤ 0.3% (<i>n</i> = 5). |
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| language | English |
| last_indexed | 2024-03-09T17:33:04Z |
| publishDate | 2022-11-01 |
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| series | Sensors |
| spelling | doaj.art-989707ccb7f84548a6e929cb3399b5f22023-11-24T12:08:55ZengMDPI AGSensors1424-82202022-11-012223912810.3390/s22239128Two Versatile Pencil Graphite–Polymer Sensor Electrodes Coupled with Potentiometry and Potentiometric Titration Methods: Profiling Determinations of Vitamin V in Tablets and Urine SamplesAbeer M. E. Hassan0Mohamed A. El Hamd1Mahmoud H. El-Maghrabey2Wael A. Mahdi3Sultan Alshehri4Hany A. Batakoushy5Department of Chemistry, Faculty of Pharmacy, 6 October University, 6th of October City 12585, EgyptDepartment of Pharmaceutical Sciences, College of Pharmacy, Shaqra University, Shaqra 11961, Saudi ArabiaDepartment of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, EgyptDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Menoufia University, Shebin Elkom 32511, EgyptHerein, we developed a new pencil graphite ion-selective electrode strategy for the broadly used erectile dysfunction medication, sildenafil citrate (SC, vitamin V), for its automated potentiometry and potentiometric titration profiling in marketed tablets and human urine samples. The method was based on ion-pair complexation between SC and sodium tetraphenylborate (Na-TPB) or phosphotungstic acid (PTA), embedded into a pencil-fabricated graphite sensor electrode coated with poly(vinyl chloride, PVC) matrix, which is pre-plasticized with two different pre-studied plasticizers. The modern fabricated electrodes have a proven fast near-Nernstian response for SC over the concentration range of 1.0 × 10<sup>−6</sup> to 1.0 × 10<sup>−2</sup> and 1.0 × 10<sup>−5</sup> to 1.0 × 10<sup>−2</sup> M, with LODs of 6.5 × 10<sup>−7</sup> and 5.5 × 10<sup>−6</sup> over a pH 3–6 for (SC-TPB)- and (SC-PTA)-based membrane sensors, of O-nitrophenyl octyl ether (O-NPOE) and dioctyl phthalate (DOP), respectively. The selectivity coefficients for different interferents, including many inorganic cations, sugars, and/or nitrogenous compounds, were tested and confirmed. Applications of the proposed method were conducted on the determination of SC in its tablets and urine samples under the proper conditions. The percent recovery values were compared with those obtained by an official method and showed an RSD ≤ 0.3% (<i>n</i> = 5).https://www.mdpi.com/1424-8220/22/23/9128sildenafil citrate (vitamin V)potentiometrypotentiometric titrationpencil-fabricated graphite sensor electrodeion-pair complexation |
| spellingShingle | Abeer M. E. Hassan Mohamed A. El Hamd Mahmoud H. El-Maghrabey Wael A. Mahdi Sultan Alshehri Hany A. Batakoushy Two Versatile Pencil Graphite–Polymer Sensor Electrodes Coupled with Potentiometry and Potentiometric Titration Methods: Profiling Determinations of Vitamin V in Tablets and Urine Samples Sensors sildenafil citrate (vitamin V) potentiometry potentiometric titration pencil-fabricated graphite sensor electrode ion-pair complexation |
| title | Two Versatile Pencil Graphite–Polymer Sensor Electrodes Coupled with Potentiometry and Potentiometric Titration Methods: Profiling Determinations of Vitamin V in Tablets and Urine Samples |
| title_full | Two Versatile Pencil Graphite–Polymer Sensor Electrodes Coupled with Potentiometry and Potentiometric Titration Methods: Profiling Determinations of Vitamin V in Tablets and Urine Samples |
| title_fullStr | Two Versatile Pencil Graphite–Polymer Sensor Electrodes Coupled with Potentiometry and Potentiometric Titration Methods: Profiling Determinations of Vitamin V in Tablets and Urine Samples |
| title_full_unstemmed | Two Versatile Pencil Graphite–Polymer Sensor Electrodes Coupled with Potentiometry and Potentiometric Titration Methods: Profiling Determinations of Vitamin V in Tablets and Urine Samples |
| title_short | Two Versatile Pencil Graphite–Polymer Sensor Electrodes Coupled with Potentiometry and Potentiometric Titration Methods: Profiling Determinations of Vitamin V in Tablets and Urine Samples |
| title_sort | two versatile pencil graphite polymer sensor electrodes coupled with potentiometry and potentiometric titration methods profiling determinations of vitamin v in tablets and urine samples |
| topic | sildenafil citrate (vitamin V) potentiometry potentiometric titration pencil-fabricated graphite sensor electrode ion-pair complexation |
| url | https://www.mdpi.com/1424-8220/22/23/9128 |
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