Association between calcitonin receptor gene polymorphisms and calcium stone urolithiasis: A meta-analysis
ABSTRACT Purpose It has been reported that calcitonin receptor (CALCR) gene polymorphisms might be associated with calcium stone urolithiasis. Owing to mixed and inconclusive results, we conducted a meta-analysis to summarize and clarify this association. Materials and Methods A systematic search...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Urologia
2019-11-01
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| Series: | International Brazilian Journal of Urology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382019000500901&tlng=en |
| _version_ | 1798020113642815488 |
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| author | Jinchun Xing Jiaxuan Qin Zonglong Cai Bo Duan Peide Bai |
| author_facet | Jinchun Xing Jiaxuan Qin Zonglong Cai Bo Duan Peide Bai |
| author_sort | Jinchun Xing |
| collection | DOAJ |
| description | ABSTRACT Purpose It has been reported that calcitonin receptor (CALCR) gene polymorphisms might be associated with calcium stone urolithiasis. Owing to mixed and inconclusive results, we conducted a meta-analysis to summarize and clarify this association. Materials and Methods A systematic search of studies on the association between CALCR gene polymorphisms and calcium stone urolithiasis susceptibility was conducted in databases. Results Odds ratios and 95% confidence intervals were used to pool the effect size. Five articles were included in our meta-analysis. Conclusions CALCR rs1801197 might be associated with increased risk of calcium stone urolithiasis. There is insufficient data to fully confirm the association between CALCR rs1042138 and calcium stone urolithiasis susceptibility. Well-designed studies with larger sample size and more subgroups are required to validate the risk identified in the current meta-analysis. |
| first_indexed | 2024-04-11T16:52:24Z |
| format | Article |
| id | doaj.art-98986dcaf231459bbebcdb86792e7b7e |
| institution | Directory Open Access Journal |
| issn | 1677-6119 |
| language | English |
| last_indexed | 2024-04-11T16:52:24Z |
| publishDate | 2019-11-01 |
| publisher | Sociedade Brasileira de Urologia |
| record_format | Article |
| series | International Brazilian Journal of Urology |
| spelling | doaj.art-98986dcaf231459bbebcdb86792e7b7e2022-12-22T04:13:25ZengSociedade Brasileira de UrologiaInternational Brazilian Journal of Urology1677-61192019-11-0145590190910.1590/s1677-5538.ibju.2019.0061Association between calcitonin receptor gene polymorphisms and calcium stone urolithiasis: A meta-analysisJinchun Xinghttps://orcid.org/0000-0002-1651-5223Jiaxuan QinZonglong CaiBo DuanPeide BaiABSTRACT Purpose It has been reported that calcitonin receptor (CALCR) gene polymorphisms might be associated with calcium stone urolithiasis. Owing to mixed and inconclusive results, we conducted a meta-analysis to summarize and clarify this association. Materials and Methods A systematic search of studies on the association between CALCR gene polymorphisms and calcium stone urolithiasis susceptibility was conducted in databases. Results Odds ratios and 95% confidence intervals were used to pool the effect size. Five articles were included in our meta-analysis. Conclusions CALCR rs1801197 might be associated with increased risk of calcium stone urolithiasis. There is insufficient data to fully confirm the association between CALCR rs1042138 and calcium stone urolithiasis susceptibility. Well-designed studies with larger sample size and more subgroups are required to validate the risk identified in the current meta-analysis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382019000500901&tlng=enReceptors, CalcitoninUrolithiasisMeta-Analysis [Publication Type] |
| spellingShingle | Jinchun Xing Jiaxuan Qin Zonglong Cai Bo Duan Peide Bai Association between calcitonin receptor gene polymorphisms and calcium stone urolithiasis: A meta-analysis International Brazilian Journal of Urology Receptors, Calcitonin Urolithiasis Meta-Analysis [Publication Type] |
| title | Association between calcitonin receptor gene polymorphisms and calcium stone urolithiasis: A meta-analysis |
| title_full | Association between calcitonin receptor gene polymorphisms and calcium stone urolithiasis: A meta-analysis |
| title_fullStr | Association between calcitonin receptor gene polymorphisms and calcium stone urolithiasis: A meta-analysis |
| title_full_unstemmed | Association between calcitonin receptor gene polymorphisms and calcium stone urolithiasis: A meta-analysis |
| title_short | Association between calcitonin receptor gene polymorphisms and calcium stone urolithiasis: A meta-analysis |
| title_sort | association between calcitonin receptor gene polymorphisms and calcium stone urolithiasis a meta analysis |
| topic | Receptors, Calcitonin Urolithiasis Meta-Analysis [Publication Type] |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382019000500901&tlng=en |
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