Block catiomers with flanking hydrolyzable tyrosinate groups enhance in vivo mRNA delivery via π–π stacking-assisted micellar assembly

Block catiomers with flanking hydrolyzable tyrosinate groups enhance in vivo mRNA delivery via π–π stacking-assisted micellar assembly

ABSTRACTMessenger RNA (mRNA) therapeutics have recently demonstrated high clinical potential with the accelerated approval of SARS-CoV-2 vaccines. To fulfill the promise of unprecedented mRNA-based treatments, the development of safe and efficient carriers is still necessary to achieve effective del...

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Bibliographic Details
Main Authors: Wenqian Yang, Takuya Miyazaki, Yasuhiro Nakagawa, Eger Boonstra, Keita Masuda, Yuki Nakashima, Pengwen Chen, Lucas Mixich, Kevin Barthelmes, Akira Matsumoto, Peng Mi, Satoshi Uchida, Horacio Cabral
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Science and Technology of Advanced Materials
Subjects:
Messenger RNA
nanomedicine
polymeric micelles
π–π interaction
poly(ethylene glycol)-poly(glycerol)
biocompatible
Online Access:https://www.tandfonline.com/doi/10.1080/14686996.2023.2170164

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