Nuanced role for dendritic cell intrinsic IRE1 RNase in the regulation of antitumor adaptive immunity

Nuanced role for dendritic cell intrinsic IRE1 RNase in the regulation of antitumor adaptive immunity

In cancer, activation of the IRE1/XBP1s axis of the unfolded protein response (UPR) promotes immunosuppression and tumor growth, by acting in cancer cells and tumor infiltrating immune cells. However, the role of IRE1/XBP1s in dendritic cells (DCs) in tumors, particularly in conventional type 1 DCs...

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Bibliographic Details
Main Authors: Felipe Flores-Santibañez, Sofie Rennen, Dominique Fernández, Clint De Nolf, Evelien Van De Velde, Sandra Gaete González, Camila Fuentes, Carolina Moreno, Diego Figueroa, Álvaro Lladser, Takao Iwawaki, María Rosa Bono, Sophie Janssens, Fabiola Osorio
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Immunology
Subjects:
dendritic cells
immunity
IRE1
melanoma
unfolded protein response
XBP1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1209588/full

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