Causal relationship between affect disorders and endometrial cancer: a Mendelian randomisation study
AbstractBackground The aim was to assess the causal relationship between depression and anxiety disorders and endometrial cancer.Method We performed two-sample Mendelian randomisation analysis using summary statistics from genome-wide association studies to assess associations of major depressive di...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Journal of Obstetrics and Gynaecology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/01443615.2024.2321321 |
| _version_ | 1797289675424006144 |
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| author | Yewu Sun Shuo Geng Chunmeng Fu Xiaoyan Song Hua Lin Yidan Xu |
| author_facet | Yewu Sun Shuo Geng Chunmeng Fu Xiaoyan Song Hua Lin Yidan Xu |
| author_sort | Yewu Sun |
| collection | DOAJ |
| description | AbstractBackground The aim was to assess the causal relationship between depression and anxiety disorders and endometrial cancer.Method We performed two-sample Mendelian randomisation analysis using summary statistics from genome-wide association studies to assess associations of major depressive disorder, anxiety and stress-related disorders with endometrial cancer. The genome-wide association studies(GWASs) data were derived from participants of predominantly European ancestry included in the Genome-wide Association Research Collaboration. Inverse variance-weighted, MR-Egger and weighted median MR analyses were performed, together with a range of sensitivity analyses.Results Mendelian randomisation analysis showed no statistically significant genetic responsibility effect of anxiety and stress-related disorders on any pathological type of endometrial cancer. Only the effect of major depressive disorder under the inverse variance weighting method increasing the risk of endometrial endometrial cancer (effect 0.004 p = 0.047) and the effect of major depressive disorder under the MR-Egger method decreasing endometrial cancer of all pathology types (effect −0.691 p = 0.015) were statistically significant. Other Mendelian randomisation analyses did not show a statistically significant effect.Conclusion Major depressive disorder(MDD), anxiety and stress-related disorders(ASRD) are not genetically responsible for endometrial cancer. We consider that emotional disorders may affect endometrial cancer indirectly by affecting body mass index. This study provides us with new insights to better understand the aetiology of endometrial cancer and inform prevention strategies. |
| first_indexed | 2024-03-07T19:08:32Z |
| format | Article |
| id | doaj.art-989ab4ff2941416e8ea003d707473ff8 |
| institution | Directory Open Access Journal |
| issn | 0144-3615 1364-6893 |
| language | English |
| last_indexed | 2024-03-07T19:08:32Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Obstetrics and Gynaecology |
| spelling | doaj.art-989ab4ff2941416e8ea003d707473ff82024-03-01T05:56:53ZengTaylor & Francis GroupJournal of Obstetrics and Gynaecology0144-36151364-68932024-12-0144110.1080/01443615.2024.2321321Causal relationship between affect disorders and endometrial cancer: a Mendelian randomisation studyYewu Sun0Shuo Geng1Chunmeng Fu2Xiaoyan Song3Hua Lin4Yidan Xu5Department of Gynaecology, The Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Clinical Psychology, The Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Anesthesiology, The Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Gynaecology, The Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Endocrinology, The Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Orthopedics, The Affiliated Hospital of Qingdao University, Qingdao, ChinaAbstractBackground The aim was to assess the causal relationship between depression and anxiety disorders and endometrial cancer.Method We performed two-sample Mendelian randomisation analysis using summary statistics from genome-wide association studies to assess associations of major depressive disorder, anxiety and stress-related disorders with endometrial cancer. The genome-wide association studies(GWASs) data were derived from participants of predominantly European ancestry included in the Genome-wide Association Research Collaboration. Inverse variance-weighted, MR-Egger and weighted median MR analyses were performed, together with a range of sensitivity analyses.Results Mendelian randomisation analysis showed no statistically significant genetic responsibility effect of anxiety and stress-related disorders on any pathological type of endometrial cancer. Only the effect of major depressive disorder under the inverse variance weighting method increasing the risk of endometrial endometrial cancer (effect 0.004 p = 0.047) and the effect of major depressive disorder under the MR-Egger method decreasing endometrial cancer of all pathology types (effect −0.691 p = 0.015) were statistically significant. Other Mendelian randomisation analyses did not show a statistically significant effect.Conclusion Major depressive disorder(MDD), anxiety and stress-related disorders(ASRD) are not genetically responsible for endometrial cancer. We consider that emotional disorders may affect endometrial cancer indirectly by affecting body mass index. This study provides us with new insights to better understand the aetiology of endometrial cancer and inform prevention strategies.https://www.tandfonline.com/doi/10.1080/01443615.2024.2321321Affect disorderdepressionanxietyrisk factorMendelian randomisation |
| spellingShingle | Yewu Sun Shuo Geng Chunmeng Fu Xiaoyan Song Hua Lin Yidan Xu Causal relationship between affect disorders and endometrial cancer: a Mendelian randomisation study Journal of Obstetrics and Gynaecology Affect disorder depression anxiety risk factor Mendelian randomisation |
| title | Causal relationship between affect disorders and endometrial cancer: a Mendelian randomisation study |
| title_full | Causal relationship between affect disorders and endometrial cancer: a Mendelian randomisation study |
| title_fullStr | Causal relationship between affect disorders and endometrial cancer: a Mendelian randomisation study |
| title_full_unstemmed | Causal relationship between affect disorders and endometrial cancer: a Mendelian randomisation study |
| title_short | Causal relationship between affect disorders and endometrial cancer: a Mendelian randomisation study |
| title_sort | causal relationship between affect disorders and endometrial cancer a mendelian randomisation study |
| topic | Affect disorder depression anxiety risk factor Mendelian randomisation |
| url | https://www.tandfonline.com/doi/10.1080/01443615.2024.2321321 |
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