Tobacco smoking associates with NF1 mutations exacerbating survival outcomes in gliomas
Abstract Tobacco smoking is associated with increased risks of nearly 20 types of cancer. Although the association between smoking and gliomas, the most prevalent type of adult brain tumor, is still unconclusive, here, we found that the frequency of NF1 mutations was significantly increased in the g...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | Biomarker Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40364-022-00430-z |
| _version_ | 1798018404844568576 |
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| author | Xi Li Han Yan Jun Wu Longbo Zhang |
| author_facet | Xi Li Han Yan Jun Wu Longbo Zhang |
| author_sort | Xi Li |
| collection | DOAJ |
| description | Abstract Tobacco smoking is associated with increased risks of nearly 20 types of cancer. Although the association between smoking and gliomas, the most prevalent type of adult brain tumor, is still unconclusive, here, we found that the frequency of NF1 mutations was significantly increased in the glioma patients with smoking history compared to non-smoking patients (24% vs. 10%, P = 0.021). NF1 acts as a tumor suppressor gene is highly mutated in gliomas. The TCGA data analysis indicated that glioma patients carrying NF1 somatic mutations have worse overall survival (median survival time: smoking 19.9 months vs. non-smoking 36.8 month; P = 0.0018). In addition, we revealed that the NF1 and IDH1 mutations were mutually exclusive suggesting NF1 mutation has independent molecular mechanism involved in glioma biology. |
| first_indexed | 2024-04-11T16:23:33Z |
| format | Article |
| id | doaj.art-989c1f96bf8b4237a915490e09c70e4c |
| institution | Directory Open Access Journal |
| issn | 2050-7771 |
| language | English |
| last_indexed | 2024-04-11T16:23:33Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Biomarker Research |
| spelling | doaj.art-989c1f96bf8b4237a915490e09c70e4c2022-12-22T04:14:15ZengBMCBiomarker Research2050-77712022-11-011011310.1186/s40364-022-00430-zTobacco smoking associates with NF1 mutations exacerbating survival outcomes in gliomasXi Li0Han Yan1Jun Wu2Longbo Zhang3Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South UniversityDepartment of Pharmacy, The Second Xiangya Hospital, Central South UniversityNational Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Central South UniversityDepartments of Neurosurgery, Xiangya Hospital, Central South UniversityAbstract Tobacco smoking is associated with increased risks of nearly 20 types of cancer. Although the association between smoking and gliomas, the most prevalent type of adult brain tumor, is still unconclusive, here, we found that the frequency of NF1 mutations was significantly increased in the glioma patients with smoking history compared to non-smoking patients (24% vs. 10%, P = 0.021). NF1 acts as a tumor suppressor gene is highly mutated in gliomas. The TCGA data analysis indicated that glioma patients carrying NF1 somatic mutations have worse overall survival (median survival time: smoking 19.9 months vs. non-smoking 36.8 month; P = 0.0018). In addition, we revealed that the NF1 and IDH1 mutations were mutually exclusive suggesting NF1 mutation has independent molecular mechanism involved in glioma biology.https://doi.org/10.1186/s40364-022-00430-zTobacco smokingGliomaNF1 gene |
| spellingShingle | Xi Li Han Yan Jun Wu Longbo Zhang Tobacco smoking associates with NF1 mutations exacerbating survival outcomes in gliomas Biomarker Research Tobacco smoking Glioma NF1 gene |
| title | Tobacco smoking associates with NF1 mutations exacerbating survival outcomes in gliomas |
| title_full | Tobacco smoking associates with NF1 mutations exacerbating survival outcomes in gliomas |
| title_fullStr | Tobacco smoking associates with NF1 mutations exacerbating survival outcomes in gliomas |
| title_full_unstemmed | Tobacco smoking associates with NF1 mutations exacerbating survival outcomes in gliomas |
| title_short | Tobacco smoking associates with NF1 mutations exacerbating survival outcomes in gliomas |
| title_sort | tobacco smoking associates with nf1 mutations exacerbating survival outcomes in gliomas |
| topic | Tobacco smoking Glioma NF1 gene |
| url | https://doi.org/10.1186/s40364-022-00430-z |
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