Microencapsulated hawthorn berry polyphenols alleviate exercise fatigue in mice by regulating AMPK signaling pathway and balancing intestinal microflora
This study prepared hawthorn polyphenol microcapsules (HPM) by microencapsulation and revealed that its potential mechanism of action in fatigued mice involves regulation of AMPK signaling pathway and balancing the intestinal microflora. Spray drying process improved thermal stability of hawthorn po...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-10-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464622003255 |
| _version_ | 1811264969758474240 |
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| author | Jincheng Yu Wenhong Jiang Shuyu Wang Suwen Liu Donglin Shi Hao Wang Xuedong Chang |
| author_facet | Jincheng Yu Wenhong Jiang Shuyu Wang Suwen Liu Donglin Shi Hao Wang Xuedong Chang |
| author_sort | Jincheng Yu |
| collection | DOAJ |
| description | This study prepared hawthorn polyphenol microcapsules (HPM) by microencapsulation and revealed that its potential mechanism of action in fatigued mice involves regulation of AMPK signaling pathway and balancing the intestinal microflora. Spray drying process improved thermal stability of hawthorn polyphenol. After HPM treatment, the weight-bearing swimming ability of fatigued mice was significantly improved (p < 0.05). HPM can effectively improve skeletal muscle substrate consumption and product metabolism and enhance antioxidant capacity (p < 0.05 or p < 0.01). Supplementation with HPM can provide energy through regulation of the PI3K/AKT/GSK-3Β pathway. HPM activated the AMPK pathway (p < 0.05 or p < 0.01) to improve mitochondrial dysfunction and cell metabolism and inhibited the NF-κB inflammatory pathway (p < 0.05) in fatigued mice. In addition, HPM can exhibit an anti-fatigue effect by improving the diversity of gut microbial species. Therefore, HPM can be used as a potential anti-fatigue nutritional supplement in functional foods to alleviate exercise fatigue. |
| first_indexed | 2024-04-12T20:14:02Z |
| format | Article |
| id | doaj.art-989ccca4299d4f2ebe864950dcad52be |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-04-12T20:14:02Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-989ccca4299d4f2ebe864950dcad52be2022-12-22T03:18:10ZengElsevierJournal of Functional Foods1756-46462022-10-0197105255Microencapsulated hawthorn berry polyphenols alleviate exercise fatigue in mice by regulating AMPK signaling pathway and balancing intestinal microfloraJincheng Yu0Wenhong Jiang1Shuyu Wang2Suwen Liu3Donglin Shi4Hao Wang5Xuedong Chang6College of Food Science & Technology, Hebei Yanshan Special Industrial Technology Research Institute, Hebei Normal University of Science and Technology, Qinhuangdao, Hebei 066004, ChinaCollege of Food Science & Technology, Hebei Yanshan Special Industrial Technology Research Institute, Hebei Normal University of Science and Technology, Qinhuangdao, Hebei 066004, China; Cofco Great Wall Wine (Ningxia) Co, Ltd., Yinchuan, Ningxia 750100, ChinaCollege of Food Science & Technology, Hebei Yanshan Special Industrial Technology Research Institute, Hebei Normal University of Science and Technology, Qinhuangdao, Hebei 066004, ChinaCollege of Food Science & Technology, Hebei Yanshan Special Industrial Technology Research Institute, Hebei Normal University of Science and Technology, Qinhuangdao, Hebei 066004, China; Corresponding authors.Department of Physical Education, Hebei Sport University, Shijiazhuang, Hebei 050011, China; Corresponding authors.State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology (TUST), Tianjin 300457, ChinaCollege of Food Science & Technology, Hebei Yanshan Special Industrial Technology Research Institute, Hebei Normal University of Science and Technology, Qinhuangdao, Hebei 066004, ChinaThis study prepared hawthorn polyphenol microcapsules (HPM) by microencapsulation and revealed that its potential mechanism of action in fatigued mice involves regulation of AMPK signaling pathway and balancing the intestinal microflora. Spray drying process improved thermal stability of hawthorn polyphenol. After HPM treatment, the weight-bearing swimming ability of fatigued mice was significantly improved (p < 0.05). HPM can effectively improve skeletal muscle substrate consumption and product metabolism and enhance antioxidant capacity (p < 0.05 or p < 0.01). Supplementation with HPM can provide energy through regulation of the PI3K/AKT/GSK-3Β pathway. HPM activated the AMPK pathway (p < 0.05 or p < 0.01) to improve mitochondrial dysfunction and cell metabolism and inhibited the NF-κB inflammatory pathway (p < 0.05) in fatigued mice. In addition, HPM can exhibit an anti-fatigue effect by improving the diversity of gut microbial species. Therefore, HPM can be used as a potential anti-fatigue nutritional supplement in functional foods to alleviate exercise fatigue.http://www.sciencedirect.com/science/article/pii/S1756464622003255Hawthorn polyphenolMicrocapsuleAnti-fatigueIntestinal microfloraInflammation |
| spellingShingle | Jincheng Yu Wenhong Jiang Shuyu Wang Suwen Liu Donglin Shi Hao Wang Xuedong Chang Microencapsulated hawthorn berry polyphenols alleviate exercise fatigue in mice by regulating AMPK signaling pathway and balancing intestinal microflora Journal of Functional Foods Hawthorn polyphenol Microcapsule Anti-fatigue Intestinal microflora Inflammation |
| title | Microencapsulated hawthorn berry polyphenols alleviate exercise fatigue in mice by regulating AMPK signaling pathway and balancing intestinal microflora |
| title_full | Microencapsulated hawthorn berry polyphenols alleviate exercise fatigue in mice by regulating AMPK signaling pathway and balancing intestinal microflora |
| title_fullStr | Microencapsulated hawthorn berry polyphenols alleviate exercise fatigue in mice by regulating AMPK signaling pathway and balancing intestinal microflora |
| title_full_unstemmed | Microencapsulated hawthorn berry polyphenols alleviate exercise fatigue in mice by regulating AMPK signaling pathway and balancing intestinal microflora |
| title_short | Microencapsulated hawthorn berry polyphenols alleviate exercise fatigue in mice by regulating AMPK signaling pathway and balancing intestinal microflora |
| title_sort | microencapsulated hawthorn berry polyphenols alleviate exercise fatigue in mice by regulating ampk signaling pathway and balancing intestinal microflora |
| topic | Hawthorn polyphenol Microcapsule Anti-fatigue Intestinal microflora Inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S1756464622003255 |
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