Causal relationship between gut microbiota and prostate cancer contributes to the gut-prostate axis: insights from a Mendelian randomization study
Abstract Background Changes in gut microbiota abundance have been linked to prostate cancer development. However, the causality of the gut-prostate axis remains unclear. Methods The genome-wide association study (GWAS) data for gut microbiota sourced from MiBioGen (n = 14,306), alongside prostate ca...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2024-03-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-024-00925-1 |
| _version_ | 1827327068281503744 |
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| author | Li Wang Yong-bo Zheng Shan Yin Kun-peng Li Jia-hao Wang Er-hao Bao Ping-yu Zhu |
| author_facet | Li Wang Yong-bo Zheng Shan Yin Kun-peng Li Jia-hao Wang Er-hao Bao Ping-yu Zhu |
| author_sort | Li Wang |
| collection | DOAJ |
| description | Abstract Background Changes in gut microbiota abundance have been linked to prostate cancer development. However, the causality of the gut-prostate axis remains unclear. Methods The genome-wide association study (GWAS) data for gut microbiota sourced from MiBioGen (n = 14,306), alongside prostate cancer summary data from PRACTICAL (n = 140,254) and FinnGen Consortium (n = 133,164). Inverse-variance-weighted (IVW) was mainly used to compute odds ratios (OR) and 95% confidence intervals (Cl), after diligently scrutinizing potential sources of heterogeneity and horizontal pleiotropy via the rigorous utilization of Cochran's Q test, the MR-PRESSO method, and MR-Egger. We used meta-analysis methods in random effects to combine the Mendelian randomization (MR) estimates from the two sources. Results The pooled analyses of MR results show that genus Eubacterium fissicatena (OR = 1.07, 95% CI 1.01 to 1.13, P = 0.011) and genus Odoribacter (OR = 1.14, 95% CI 1.01 to 1.27, P = 0.025) were positively associated with prostate cancer. However, genus Adlercreutzia (OR = 0.89, 95% CI 0.83 to 0.96, P = 0.002), Roseburia (OR = 0.90, 95% CI 0.83 to 0.99, P = 0.03), Holdemania (OR = 0.92, 95% CI 0.86 to 0.97, P = 0.005), Flavonifractor (OR = 0.85, 95% CI 0.74 to 0.98, P = 0.024) and Allisonella (OR = 0.93, 95% CI 0.89 to 0.98, P = 0.011) seems to be a protective factor for prostate cancer. Sensitivity analysis found no significant heterogeneity, horizontal pleiotropy, or reverse causal links in all causal associations. Conclusion This MR study lends support to a causal relationship between genetically predicted gut microbiota and prostate cancer. Research on the gut-prostate axis, along with further multi-omics analyses, holds significant implications for the prevention and treatment of prostate cancer. |
| first_indexed | 2024-03-07T14:54:42Z |
| format | Article |
| id | doaj.art-989d042d8ed14cfb89e1c427b91c41ca |
| institution | Directory Open Access Journal |
| issn | 2730-6011 |
| language | English |
| last_indexed | 2024-03-07T14:54:42Z |
| publishDate | 2024-03-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj.art-989d042d8ed14cfb89e1c427b91c41ca2024-03-05T19:30:24ZengSpringerDiscover Oncology2730-60112024-03-0115111010.1007/s12672-024-00925-1Causal relationship between gut microbiota and prostate cancer contributes to the gut-prostate axis: insights from a Mendelian randomization studyLi Wang0Yong-bo Zheng1Shan Yin2Kun-peng Li3Jia-hao Wang4Er-hao Bao5Ping-yu Zhu6Department of Urology, Affiliated Hospital of North Sichuan Medical CollegeDepartment of Urology, Affiliated Hospital of North Sichuan Medical CollegeDepartment of Urology, Affiliated Hospital of North Sichuan Medical CollegeDepartment of Urology, The Second Hospital of Lanzhou UniversityDepartment of Urology, Affiliated Hospital of North Sichuan Medical CollegeDepartment of Urology, Affiliated Hospital of North Sichuan Medical CollegeDepartment of Urology, Affiliated Hospital of North Sichuan Medical CollegeAbstract Background Changes in gut microbiota abundance have been linked to prostate cancer development. However, the causality of the gut-prostate axis remains unclear. Methods The genome-wide association study (GWAS) data for gut microbiota sourced from MiBioGen (n = 14,306), alongside prostate cancer summary data from PRACTICAL (n = 140,254) and FinnGen Consortium (n = 133,164). Inverse-variance-weighted (IVW) was mainly used to compute odds ratios (OR) and 95% confidence intervals (Cl), after diligently scrutinizing potential sources of heterogeneity and horizontal pleiotropy via the rigorous utilization of Cochran's Q test, the MR-PRESSO method, and MR-Egger. We used meta-analysis methods in random effects to combine the Mendelian randomization (MR) estimates from the two sources. Results The pooled analyses of MR results show that genus Eubacterium fissicatena (OR = 1.07, 95% CI 1.01 to 1.13, P = 0.011) and genus Odoribacter (OR = 1.14, 95% CI 1.01 to 1.27, P = 0.025) were positively associated with prostate cancer. However, genus Adlercreutzia (OR = 0.89, 95% CI 0.83 to 0.96, P = 0.002), Roseburia (OR = 0.90, 95% CI 0.83 to 0.99, P = 0.03), Holdemania (OR = 0.92, 95% CI 0.86 to 0.97, P = 0.005), Flavonifractor (OR = 0.85, 95% CI 0.74 to 0.98, P = 0.024) and Allisonella (OR = 0.93, 95% CI 0.89 to 0.98, P = 0.011) seems to be a protective factor for prostate cancer. Sensitivity analysis found no significant heterogeneity, horizontal pleiotropy, or reverse causal links in all causal associations. Conclusion This MR study lends support to a causal relationship between genetically predicted gut microbiota and prostate cancer. Research on the gut-prostate axis, along with further multi-omics analyses, holds significant implications for the prevention and treatment of prostate cancer.https://doi.org/10.1007/s12672-024-00925-1Mendelian randomizationProstate cancerRiskGut microbiotaGene |
| spellingShingle | Li Wang Yong-bo Zheng Shan Yin Kun-peng Li Jia-hao Wang Er-hao Bao Ping-yu Zhu Causal relationship between gut microbiota and prostate cancer contributes to the gut-prostate axis: insights from a Mendelian randomization study Discover Oncology Mendelian randomization Prostate cancer Risk Gut microbiota Gene |
| title | Causal relationship between gut microbiota and prostate cancer contributes to the gut-prostate axis: insights from a Mendelian randomization study |
| title_full | Causal relationship between gut microbiota and prostate cancer contributes to the gut-prostate axis: insights from a Mendelian randomization study |
| title_fullStr | Causal relationship between gut microbiota and prostate cancer contributes to the gut-prostate axis: insights from a Mendelian randomization study |
| title_full_unstemmed | Causal relationship between gut microbiota and prostate cancer contributes to the gut-prostate axis: insights from a Mendelian randomization study |
| title_short | Causal relationship between gut microbiota and prostate cancer contributes to the gut-prostate axis: insights from a Mendelian randomization study |
| title_sort | causal relationship between gut microbiota and prostate cancer contributes to the gut prostate axis insights from a mendelian randomization study |
| topic | Mendelian randomization Prostate cancer Risk Gut microbiota Gene |
| url | https://doi.org/10.1007/s12672-024-00925-1 |
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