Relationship between Maternal and First Year of Life Dispensations of Antibiotics and Antiasthmatics
Antibiotics are the most frequent prescription drugs used by pregnant women. Our objective was to investigate if the dispensation of antibiotics and antiasthmatics in children less than 1 year of age is associated with prenatal antibiotic exposure. A secondary aim was to explore the incidence of dis...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2018-09-01
|
| Series: | Antibiotics |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2079-6382/7/3/84 |
| _version_ | 1818675261671997440 |
|---|---|
| author | Guro Haugen Fossum Morten Lindbæk Svein Gjelstad Kari J. Kværner |
| author_facet | Guro Haugen Fossum Morten Lindbæk Svein Gjelstad Kari J. Kværner |
| author_sort | Guro Haugen Fossum |
| collection | DOAJ |
| description | Antibiotics are the most frequent prescription drugs used by pregnant women. Our objective was to investigate if the dispensation of antibiotics and antiasthmatics in children less than 1 year of age is associated with prenatal antibiotic exposure. A secondary aim was to explore the incidence of dispensed antibiotics in pregnancy and dispensed antibiotics and antiasthmatics in children. We conducted an observational study using the Peer Academic Detailing study database to select patients eligible for match in the Medical Birth Registry of Norway, a total of 7747 mother-and-child pairs. Details on antibiotic and antiasthmatic pharmacy dispensations were obtained from the Norwegian Prescription Database. One quarter (1948 of 7747) of the mothers in the study had been dispensed antibiotics during pregnancy. In their first year of life, 17% (1289) of the children had had an antibiotic dispensation, 23% (1747) an antiasthmatic dispensation, and 8% (619) of the children had had both. We found a significant association between dispensed antibiotics in pregnancy and dispensed antibiotics to the child during their first year of life; OR = 1.16 (95% CI: 1.002–1.351). The association was stronger when the mothers were dispensed antibiotics at all, independent of the pregnancy period; OR = 1.60 (95% CI: 1.32–1.94). We conclude that the probability for dispensation of antibiotics was increased in children when mothers were dispensed antibiotics, independent of pregnancy. Diagnostic challenges in the very young and parental doctor-seeking behavior may, at least in part, contribute to the association between dispensations in mothers and children below the age of one year. |
| first_indexed | 2024-12-17T08:24:46Z |
| format | Article |
| id | doaj.art-989d27f376614d4aab895de703e2d816 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-12-17T08:24:46Z |
| publishDate | 2018-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-989d27f376614d4aab895de703e2d8162022-12-21T21:56:49ZengMDPI AGAntibiotics2079-63822018-09-01738410.3390/antibiotics7030084antibiotics7030084Relationship between Maternal and First Year of Life Dispensations of Antibiotics and AntiasthmaticsGuro Haugen Fossum0Morten Lindbæk1Svein Gjelstad2Kari J. Kværner3Antibiotic Center for Primary Care, Department of General Practice, Institute of Health and Society, University of Oslo, P.O. Box 1130 Blindern, N-0318 Oslo, NorwayAntibiotic Center for Primary Care, Department of General Practice, Institute of Health and Society, University of Oslo, P.O. Box 1130 Blindern, N-0318 Oslo, NorwayAntibiotic Center for Primary Care, Department of General Practice, Institute of Health and Society, University of Oslo, P.O. Box 1130 Blindern, N-0318 Oslo, NorwayC3-Centre for Connected Care, Oslo University Hospital, N-0424 Oslo, NorwayAntibiotics are the most frequent prescription drugs used by pregnant women. Our objective was to investigate if the dispensation of antibiotics and antiasthmatics in children less than 1 year of age is associated with prenatal antibiotic exposure. A secondary aim was to explore the incidence of dispensed antibiotics in pregnancy and dispensed antibiotics and antiasthmatics in children. We conducted an observational study using the Peer Academic Detailing study database to select patients eligible for match in the Medical Birth Registry of Norway, a total of 7747 mother-and-child pairs. Details on antibiotic and antiasthmatic pharmacy dispensations were obtained from the Norwegian Prescription Database. One quarter (1948 of 7747) of the mothers in the study had been dispensed antibiotics during pregnancy. In their first year of life, 17% (1289) of the children had had an antibiotic dispensation, 23% (1747) an antiasthmatic dispensation, and 8% (619) of the children had had both. We found a significant association between dispensed antibiotics in pregnancy and dispensed antibiotics to the child during their first year of life; OR = 1.16 (95% CI: 1.002–1.351). The association was stronger when the mothers were dispensed antibiotics at all, independent of the pregnancy period; OR = 1.60 (95% CI: 1.32–1.94). We conclude that the probability for dispensation of antibiotics was increased in children when mothers were dispensed antibiotics, independent of pregnancy. Diagnostic challenges in the very young and parental doctor-seeking behavior may, at least in part, contribute to the association between dispensations in mothers and children below the age of one year.http://www.mdpi.com/2079-6382/7/3/84antibacterial agentspregnancychildrenasthma medicationpharmacoepidemiology |
| spellingShingle | Guro Haugen Fossum Morten Lindbæk Svein Gjelstad Kari J. Kværner Relationship between Maternal and First Year of Life Dispensations of Antibiotics and Antiasthmatics Antibiotics antibacterial agents pregnancy children asthma medication pharmacoepidemiology |
| title | Relationship between Maternal and First Year of Life Dispensations of Antibiotics and Antiasthmatics |
| title_full | Relationship between Maternal and First Year of Life Dispensations of Antibiotics and Antiasthmatics |
| title_fullStr | Relationship between Maternal and First Year of Life Dispensations of Antibiotics and Antiasthmatics |
| title_full_unstemmed | Relationship between Maternal and First Year of Life Dispensations of Antibiotics and Antiasthmatics |
| title_short | Relationship between Maternal and First Year of Life Dispensations of Antibiotics and Antiasthmatics |
| title_sort | relationship between maternal and first year of life dispensations of antibiotics and antiasthmatics |
| topic | antibacterial agents pregnancy children asthma medication pharmacoepidemiology |
| url | http://www.mdpi.com/2079-6382/7/3/84 |
| work_keys_str_mv | AT gurohaugenfossum relationshipbetweenmaternalandfirstyearoflifedispensationsofantibioticsandantiasthmatics AT mortenlindbæk relationshipbetweenmaternalandfirstyearoflifedispensationsofantibioticsandantiasthmatics AT sveingjelstad relationshipbetweenmaternalandfirstyearoflifedispensationsofantibioticsandantiasthmatics AT karijkværner relationshipbetweenmaternalandfirstyearoflifedispensationsofantibioticsandantiasthmatics |