Analysis of Adverse Effects of COVID-19 Vaccines Experienced by Healthcare Workers at Guizhou Provincial Staff Hospital, China
Objective: A retrospective survey was conducted of adverse events following immunization (AEFI) experienced by health care workers (HCWs) in a relatively remote ethnic region in southwest China (Guizhou Province) who received COVID-19 vaccines. Methods: From 18 January 2021 to 21 January 2022, all H...
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MDPI AG
2022-09-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/9/1449 |
| _version_ | 1797481637362008064 |
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| author | Yunhua Wei Yan Wang Lin Liu Yan Zha Yuqi Yang Yuanlin Wang Neil Roberts Yaying Li |
| author_facet | Yunhua Wei Yan Wang Lin Liu Yan Zha Yuqi Yang Yuanlin Wang Neil Roberts Yaying Li |
| author_sort | Yunhua Wei |
| collection | DOAJ |
| description | Objective: A retrospective survey was conducted of adverse events following immunization (AEFI) experienced by health care workers (HCWs) in a relatively remote ethnic region in southwest China (Guizhou Province) who received COVID-19 vaccines. Methods: From 18 January 2021 to 21 January 2022, all HCWs of Guizhou Provincial Staff Hospital, China, who received at least one dose of inactivated COVID-19 vaccine (Vero cell), recombinant novel coronavirus vaccine (CHO cell), or one dose of adenovirus type-5 (Ad5) vectored COVID-19 vaccine were asked to complete a self-report questionnaire to provide information on any adverse events that may have occurred in the first 3 days after injection. The frequency of AEFI corresponding to the three types of vaccines were compared and the potential risks of AEFI due to the three different vaccines were predicted by multivariate logistic regression analysis. Results: Of the 904 HCWs who completed the survey, the rates of AEFI were 10.1% (80/794) due to Vero cell, 16.3% (13/80) due to CHO cell, and 46.67% (14/30) due to Ad5 vectored vaccines, and the rates were significantly different (χ<sup>2</sup> = 38.7, <i>p</i> < 001) between the three vaccines. Multivariate logistic regression models predict that (1) compared to the Ad 5 vectored group, the risk of AEFI occurrence in the Vero cell group was reduced by about 85.9% (OR = 0.141, 95% CI: 0.065–0.306, <i>p</i> < 0.001) and in the CHO cell group by about 72.1% (OR = 0.279, 95% CI: 0.107–0.723, <i>p</i> = 0.009), (2) the odds for women experiencing AEFI were about 2.1 (OR = 2.093, 95% CI: 1.171–3.742, <i>p</i> = 0.013) times as high as those of men, and (3) the risk of AEFI for HCWs with a Bachelor’s degree or above was about 2.2 (OR = 2.237, 95% CI: 1.434–3.489, <i>p</i> = 0.001) times higher than in HCWs who do not have a Bachelor’s degree. Conclusions: 1. The inactivated COVID-19 vaccine (Vero cell), recombinant novel coronavirus vaccine (CHO cell), and adenovirus type-5 (Ad5) vectored COVID-19 vaccine made in China are safe and relatively broad-spectrum. 2. The prevalence of AEFI is more common in women healthcare workers. 3. The risk of AEFI was higher in those with a Bachelor’s degree or above and may be related to the psychological and social effects triggered by the global COVID-19 pandemic. |
| first_indexed | 2024-03-09T22:17:26Z |
| format | Article |
| id | doaj.art-98a12b209a4045e2bd24582a2138cfd9 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T22:17:26Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-98a12b209a4045e2bd24582a2138cfd92023-11-23T19:21:17ZengMDPI AGVaccines2076-393X2022-09-01109144910.3390/vaccines10091449Analysis of Adverse Effects of COVID-19 Vaccines Experienced by Healthcare Workers at Guizhou Provincial Staff Hospital, ChinaYunhua Wei0Yan Wang1Lin Liu2Yan Zha3Yuqi Yang4Yuanlin Wang5Neil Roberts6Yaying Li7Department of Nuclear Medicine, Guizhou Provincial People’s Hospital, Affiliated Hospital of Guizhou University, Guiyang 550002, ChinaDepartment of Nuclear Medicine, Guizhou Provincial People’s Hospital, Affiliated Hospital of Guizhou University, Guiyang 550002, ChinaDepartment of Nuclear Medicine, Guizhou Provincial People’s Hospital, Affiliated Hospital of Guizhou University, Guiyang 550002, ChinaDepartment of Nuclear Medicine, Guizhou Provincial People’s Hospital, Affiliated Hospital of Guizhou University, Guiyang 550002, ChinaDepartment of Nuclear Medicine, Guizhou Provincial People’s Hospital, Affiliated Hospital of Guizhou University, Guiyang 550002, ChinaDepartment of Nuclear Medicine, Guizhou Provincial People’s Hospital, Affiliated Hospital of Guizhou University, Guiyang 550002, ChinaSchool of Clinical Sciences, The Queen’s Medical Research Institute (QMRI), University of Edinburgh, Edinburgh EH8 9YL, UKDepartment of Nuclear Medicine, Guizhou Provincial People’s Hospital, Affiliated Hospital of Guizhou University, Guiyang 550002, ChinaObjective: A retrospective survey was conducted of adverse events following immunization (AEFI) experienced by health care workers (HCWs) in a relatively remote ethnic region in southwest China (Guizhou Province) who received COVID-19 vaccines. Methods: From 18 January 2021 to 21 January 2022, all HCWs of Guizhou Provincial Staff Hospital, China, who received at least one dose of inactivated COVID-19 vaccine (Vero cell), recombinant novel coronavirus vaccine (CHO cell), or one dose of adenovirus type-5 (Ad5) vectored COVID-19 vaccine were asked to complete a self-report questionnaire to provide information on any adverse events that may have occurred in the first 3 days after injection. The frequency of AEFI corresponding to the three types of vaccines were compared and the potential risks of AEFI due to the three different vaccines were predicted by multivariate logistic regression analysis. Results: Of the 904 HCWs who completed the survey, the rates of AEFI were 10.1% (80/794) due to Vero cell, 16.3% (13/80) due to CHO cell, and 46.67% (14/30) due to Ad5 vectored vaccines, and the rates were significantly different (χ<sup>2</sup> = 38.7, <i>p</i> < 001) between the three vaccines. Multivariate logistic regression models predict that (1) compared to the Ad 5 vectored group, the risk of AEFI occurrence in the Vero cell group was reduced by about 85.9% (OR = 0.141, 95% CI: 0.065–0.306, <i>p</i> < 0.001) and in the CHO cell group by about 72.1% (OR = 0.279, 95% CI: 0.107–0.723, <i>p</i> = 0.009), (2) the odds for women experiencing AEFI were about 2.1 (OR = 2.093, 95% CI: 1.171–3.742, <i>p</i> = 0.013) times as high as those of men, and (3) the risk of AEFI for HCWs with a Bachelor’s degree or above was about 2.2 (OR = 2.237, 95% CI: 1.434–3.489, <i>p</i> = 0.001) times higher than in HCWs who do not have a Bachelor’s degree. Conclusions: 1. The inactivated COVID-19 vaccine (Vero cell), recombinant novel coronavirus vaccine (CHO cell), and adenovirus type-5 (Ad5) vectored COVID-19 vaccine made in China are safe and relatively broad-spectrum. 2. The prevalence of AEFI is more common in women healthcare workers. 3. The risk of AEFI was higher in those with a Bachelor’s degree or above and may be related to the psychological and social effects triggered by the global COVID-19 pandemic.https://www.mdpi.com/2076-393X/10/9/1449inactivated COVID-19 vaccine (Vero cell)recombinant novel coronavirus vaccine (CHO cell)adenovirus type-5 (Ad5) vectored COVID-19 vaccinehealthcare workersadverse events following immunization |
| spellingShingle | Yunhua Wei Yan Wang Lin Liu Yan Zha Yuqi Yang Yuanlin Wang Neil Roberts Yaying Li Analysis of Adverse Effects of COVID-19 Vaccines Experienced by Healthcare Workers at Guizhou Provincial Staff Hospital, China Vaccines inactivated COVID-19 vaccine (Vero cell) recombinant novel coronavirus vaccine (CHO cell) adenovirus type-5 (Ad5) vectored COVID-19 vaccine healthcare workers adverse events following immunization |
| title | Analysis of Adverse Effects of COVID-19 Vaccines Experienced by Healthcare Workers at Guizhou Provincial Staff Hospital, China |
| title_full | Analysis of Adverse Effects of COVID-19 Vaccines Experienced by Healthcare Workers at Guizhou Provincial Staff Hospital, China |
| title_fullStr | Analysis of Adverse Effects of COVID-19 Vaccines Experienced by Healthcare Workers at Guizhou Provincial Staff Hospital, China |
| title_full_unstemmed | Analysis of Adverse Effects of COVID-19 Vaccines Experienced by Healthcare Workers at Guizhou Provincial Staff Hospital, China |
| title_short | Analysis of Adverse Effects of COVID-19 Vaccines Experienced by Healthcare Workers at Guizhou Provincial Staff Hospital, China |
| title_sort | analysis of adverse effects of covid 19 vaccines experienced by healthcare workers at guizhou provincial staff hospital china |
| topic | inactivated COVID-19 vaccine (Vero cell) recombinant novel coronavirus vaccine (CHO cell) adenovirus type-5 (Ad5) vectored COVID-19 vaccine healthcare workers adverse events following immunization |
| url | https://www.mdpi.com/2076-393X/10/9/1449 |
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