A comparative study of two different doses of magnesium sulfate on pneumoperitoneum-related hemodynamics and on the recovery in patients undergoing laparoscopic gynecological surgeries: A double-blind, randomized, clinical study
Background: Pneumoperitoneum (PP) with carbon dioxide (CO2) induces hemodynamic response due to the release of catecholamines and vasopressin. Magnesium Sulfate (MgSo4) inhibits the release of these mediators and attenuates the hemodynamic responses to carbon dioxide PP. Aims and Objectives: This...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2023-10-01
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| Series: | Asian Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/56232 |
| _version_ | 1797668321227702272 |
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| author | Reddy Mamatha Chikkanarasimha Rajappa Nulenur Rashmi Venkataramaiah Vani Nitturu Bindu Nagaraj Nagaraja Swathi |
| author_facet | Reddy Mamatha Chikkanarasimha Rajappa Nulenur Rashmi Venkataramaiah Vani Nitturu Bindu Nagaraj Nagaraja Swathi |
| author_sort | Reddy Mamatha Chikkanarasimha |
| collection | DOAJ |
| description | Background: Pneumoperitoneum (PP) with carbon dioxide (CO2) induces hemodynamic response due to the release of catecholamines and vasopressin. Magnesium Sulfate (MgSo4) inhibits the release of these mediators and attenuates the hemodynamic responses to carbon dioxide PP.
Aims and Objectives: This study aimed to compare two different doses of intravenous Magnesium Sulfate on attenuating PP-related hemodynamic responses. We also evaluated recovery time, the time interval between administration of the reversal agent and extubation.
Materials and Methods: Seventy female patients undergoing laparoscopic surgeries were randomized into two groups. Group I received 30 mg/kg of MgSo4 and Group II received 50 mg/kg of MgSo4 intravenous infusion prior to PP, respectively. Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) were measured at regular intervals. The secondary outcome, Train of four ratio (TOF%), at reversal and extubation was recorded. Recovery time was noted.
Results: Demographic data, HR, SBP, DBP, and MAP were comparable between groups I and II, with no clinical and statistical significance in the ‘P’ value. The mean TOF ratio (%) at reversal was lower in group II (58.47±5.40) versus group I (66.93±3.43), with a P<0.001. The mean TOF ratio (%) at extubation was lower in group II (93.70±2.39) versus group I (97.47±1.59), with a P<0.001. Recovery time in minutes was higher in group II (17.80±1.19) versus group I (13.87±0.67), with a P<0.001.
Conclusion: Magnesium Sulfate 30 mg/kg and 50 mg/kg intravenous infusions prior to CO2 PP showed comparable hemodynamics in laparoscopic gynecological surgery. However, Magnesium Sulfate 50 mg/kg resulted in prolonged recovery from non-depolarizing muscle relaxants, necessitating neuromuscular monitoring for safer use. |
| first_indexed | 2024-03-11T20:27:26Z |
| format | Article |
| id | doaj.art-98a17de6bc7443d8be97d60308753565 |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-03-11T20:27:26Z |
| publishDate | 2023-10-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-98a17de6bc7443d8be97d603087535652023-10-02T12:08:17ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762023-10-0114105360https://doi.org/10.3126/ajms.v14i10.56232A comparative study of two different doses of magnesium sulfate on pneumoperitoneum-related hemodynamics and on the recovery in patients undergoing laparoscopic gynecological surgeries: A double-blind, randomized, clinical studyReddy Mamatha Chikkanarasimha 0https://orcid.org/0000-0003-2630-710XRajappa Nulenur Rashmi 1https://orcid.org/0009-0001-4770-9696Venkataramaiah Vani Nitturu 2https://orcid.org/0000-0002-4973-3577Bindu Nagaraj 3https://orcid.org/0009-0001-0246-3581Nagaraja Swathi 4https://orcid.org/0000-0002-0676-8382Assistant Professor, Department of Anaesthesiology, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India Associate Professor, Department of Anaesthesiology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India Assistant Professor, Department of Anaesthesiology, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India Assistant Professor, Department of Anaesthesiology, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India Assistant Professor, Department of Anaesthesiology, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, IndiaBackground: Pneumoperitoneum (PP) with carbon dioxide (CO2) induces hemodynamic response due to the release of catecholamines and vasopressin. Magnesium Sulfate (MgSo4) inhibits the release of these mediators and attenuates the hemodynamic responses to carbon dioxide PP. Aims and Objectives: This study aimed to compare two different doses of intravenous Magnesium Sulfate on attenuating PP-related hemodynamic responses. We also evaluated recovery time, the time interval between administration of the reversal agent and extubation. Materials and Methods: Seventy female patients undergoing laparoscopic surgeries were randomized into two groups. Group I received 30 mg/kg of MgSo4 and Group II received 50 mg/kg of MgSo4 intravenous infusion prior to PP, respectively. Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) were measured at regular intervals. The secondary outcome, Train of four ratio (TOF%), at reversal and extubation was recorded. Recovery time was noted. Results: Demographic data, HR, SBP, DBP, and MAP were comparable between groups I and II, with no clinical and statistical significance in the ‘P’ value. The mean TOF ratio (%) at reversal was lower in group II (58.47±5.40) versus group I (66.93±3.43), with a P<0.001. The mean TOF ratio (%) at extubation was lower in group II (93.70±2.39) versus group I (97.47±1.59), with a P<0.001. Recovery time in minutes was higher in group II (17.80±1.19) versus group I (13.87±0.67), with a P<0.001. Conclusion: Magnesium Sulfate 30 mg/kg and 50 mg/kg intravenous infusions prior to CO2 PP showed comparable hemodynamics in laparoscopic gynecological surgery. However, Magnesium Sulfate 50 mg/kg resulted in prolonged recovery from non-depolarizing muscle relaxants, necessitating neuromuscular monitoring for safer use.https://www.nepjol.info/index.php/AJMS/article/view/56232magnesium sulfate; laparoscopy; pneumoperitoneum; hemodynamics response; recovery time |
| spellingShingle | Reddy Mamatha Chikkanarasimha Rajappa Nulenur Rashmi Venkataramaiah Vani Nitturu Bindu Nagaraj Nagaraja Swathi A comparative study of two different doses of magnesium sulfate on pneumoperitoneum-related hemodynamics and on the recovery in patients undergoing laparoscopic gynecological surgeries: A double-blind, randomized, clinical study Asian Journal of Medical Sciences magnesium sulfate; laparoscopy; pneumoperitoneum; hemodynamics response; recovery time |
| title | A comparative study of two different doses of magnesium sulfate on pneumoperitoneum-related hemodynamics and on the recovery in patients undergoing laparoscopic gynecological surgeries: A double-blind, randomized, clinical study |
| title_full | A comparative study of two different doses of magnesium sulfate on pneumoperitoneum-related hemodynamics and on the recovery in patients undergoing laparoscopic gynecological surgeries: A double-blind, randomized, clinical study |
| title_fullStr | A comparative study of two different doses of magnesium sulfate on pneumoperitoneum-related hemodynamics and on the recovery in patients undergoing laparoscopic gynecological surgeries: A double-blind, randomized, clinical study |
| title_full_unstemmed | A comparative study of two different doses of magnesium sulfate on pneumoperitoneum-related hemodynamics and on the recovery in patients undergoing laparoscopic gynecological surgeries: A double-blind, randomized, clinical study |
| title_short | A comparative study of two different doses of magnesium sulfate on pneumoperitoneum-related hemodynamics and on the recovery in patients undergoing laparoscopic gynecological surgeries: A double-blind, randomized, clinical study |
| title_sort | comparative study of two different doses of magnesium sulfate on pneumoperitoneum related hemodynamics and on the recovery in patients undergoing laparoscopic gynecological surgeries a double blind randomized clinical study |
| topic | magnesium sulfate; laparoscopy; pneumoperitoneum; hemodynamics response; recovery time |
| url | https://www.nepjol.info/index.php/AJMS/article/view/56232 |
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