An Insight into Advances in Developing Nanotechnology Based Therapeutics, Drug Delivery, Diagnostics and Vaccines: Multidimensional Applications in Tuberculosis Disease Management
Tuberculosis (TB), one of the deadliest contagious diseases, is a major concern worldwide. Long-term treatment, a high pill burden, limited compliance, and strict administration schedules are all variables that contribute to the development of MDR and XDR tuberculosis patients. The rise of multidrug...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/16/4/581 |
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| author | Hitesh Chopra Yugal Kishore Mohanta Pradipta Ranjan Rauta Ramzan Ahmed Saurov Mahanta Piyush Kumar Mishra Paramjot Panda Ali A. Rabaan Ahmad A. Alshehri Basim Othman Mohammed Abdulrahman Alshahrani Ali S. Alqahtani Baneen Ali AL Basha Kuldeep Dhama |
| author_facet | Hitesh Chopra Yugal Kishore Mohanta Pradipta Ranjan Rauta Ramzan Ahmed Saurov Mahanta Piyush Kumar Mishra Paramjot Panda Ali A. Rabaan Ahmad A. Alshehri Basim Othman Mohammed Abdulrahman Alshahrani Ali S. Alqahtani Baneen Ali AL Basha Kuldeep Dhama |
| author_sort | Hitesh Chopra |
| collection | DOAJ |
| description | Tuberculosis (TB), one of the deadliest contagious diseases, is a major concern worldwide. Long-term treatment, a high pill burden, limited compliance, and strict administration schedules are all variables that contribute to the development of MDR and XDR tuberculosis patients. The rise of multidrug-resistant strains and a scarcity of anti-TB medications pose a threat to TB control in the future. As a result, a strong and effective system is required to overcome technological limitations and improve the efficacy of therapeutic medications, which is still a huge problem for pharmacological technology. Nanotechnology offers an interesting opportunity for accurate identification of mycobacterial strains and improved medication treatment possibilities for tuberculosis. Nano medicine in tuberculosis is an emerging research field that provides the possibility of efficient medication delivery using nanoparticles and a decrease in drug dosages and adverse effects to boost patient compliance with therapy and recovery. Due to their fascinating characteristics, this strategy is useful in overcoming the abnormalities associated with traditional therapy and leads to some optimization of the therapeutic impact. It also decreases the dosing frequency and eliminates the problem of low compliance. To develop modern diagnosis techniques, upgraded treatment, and possible prevention of tuberculosis, the nanoparticle-based tests have demonstrated considerable advances. The literature search was conducted using Scopus, PubMed, Google Scholar, and Elsevier databases only. This article examines the possibility of employing nanotechnology for TB diagnosis, nanotechnology-based medicine delivery systems, and prevention for the successful elimination of TB illnesses. |
| first_indexed | 2024-03-11T04:39:29Z |
| format | Article |
| id | doaj.art-98a67b253ffe423b8fb7f1b1371358fe |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-11T04:39:29Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-98a67b253ffe423b8fb7f1b1371358fe2023-11-17T20:50:57ZengMDPI AGPharmaceuticals1424-82472023-04-0116458110.3390/ph16040581An Insight into Advances in Developing Nanotechnology Based Therapeutics, Drug Delivery, Diagnostics and Vaccines: Multidimensional Applications in Tuberculosis Disease ManagementHitesh Chopra0Yugal Kishore Mohanta1Pradipta Ranjan Rauta2Ramzan Ahmed3Saurov Mahanta4Piyush Kumar Mishra5Paramjot Panda6Ali A. Rabaan7Ahmad A. Alshehri8Basim Othman9Mohammed Abdulrahman Alshahrani10Ali S. Alqahtani11Baneen Ali AL Basha12Kuldeep Dhama13Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, IndiaNanobiotechnology and Translational Knowledge Laboratory, Department of Applied Biology, School of Biological Sciences, University of Science and Technology Meghalaya (USTM), Techno City, 9th Mile, Ri-Bhoi, Baridua 793101, Meghalaya, IndiaSchool of Biological Sciences, AIPH University, Bhubaneswar 754001, Odisha, IndiaNanobiotechnology and Translational Knowledge Laboratory, Department of Applied Biology, School of Biological Sciences, University of Science and Technology Meghalaya (USTM), Techno City, 9th Mile, Ri-Bhoi, Baridua 793101, Meghalaya, IndiaNational Institute of Electronics and Information Technology (NIELIT), Guwahati Centre, Guwahati 781008, Assam, IndiaDepartment of Botany, B. N. College, Dhubri 783324, Assam, IndiaSchool of Biological Sciences, AIPH University, Bhubaneswar 754001, Odisha, IndiaMolecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran 31311, Saudi ArabiaDepartment of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Najran University, Najran 61441, Saudi ArabiaDepartment of Public Health, Faculty of Applied Medical Sciences, Albaha University, Albaha 65779, Saudi ArabiaDepartment of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Najran University, Najran 61441, Saudi ArabiaDepartment of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Khalid University, Abha 61481, Saudi ArabiaLaboratory Department, King Fahad Specialist Hospital, Dammam 32253, Saudi ArabiaDivision of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly 243122, Uttar Pradesh, IndiaTuberculosis (TB), one of the deadliest contagious diseases, is a major concern worldwide. Long-term treatment, a high pill burden, limited compliance, and strict administration schedules are all variables that contribute to the development of MDR and XDR tuberculosis patients. The rise of multidrug-resistant strains and a scarcity of anti-TB medications pose a threat to TB control in the future. As a result, a strong and effective system is required to overcome technological limitations and improve the efficacy of therapeutic medications, which is still a huge problem for pharmacological technology. Nanotechnology offers an interesting opportunity for accurate identification of mycobacterial strains and improved medication treatment possibilities for tuberculosis. Nano medicine in tuberculosis is an emerging research field that provides the possibility of efficient medication delivery using nanoparticles and a decrease in drug dosages and adverse effects to boost patient compliance with therapy and recovery. Due to their fascinating characteristics, this strategy is useful in overcoming the abnormalities associated with traditional therapy and leads to some optimization of the therapeutic impact. It also decreases the dosing frequency and eliminates the problem of low compliance. To develop modern diagnosis techniques, upgraded treatment, and possible prevention of tuberculosis, the nanoparticle-based tests have demonstrated considerable advances. The literature search was conducted using Scopus, PubMed, Google Scholar, and Elsevier databases only. This article examines the possibility of employing nanotechnology for TB diagnosis, nanotechnology-based medicine delivery systems, and prevention for the successful elimination of TB illnesses.https://www.mdpi.com/1424-8247/16/4/581tuberculosisnanotechnologydiagnosisdrug deliveryvaccine |
| spellingShingle | Hitesh Chopra Yugal Kishore Mohanta Pradipta Ranjan Rauta Ramzan Ahmed Saurov Mahanta Piyush Kumar Mishra Paramjot Panda Ali A. Rabaan Ahmad A. Alshehri Basim Othman Mohammed Abdulrahman Alshahrani Ali S. Alqahtani Baneen Ali AL Basha Kuldeep Dhama An Insight into Advances in Developing Nanotechnology Based Therapeutics, Drug Delivery, Diagnostics and Vaccines: Multidimensional Applications in Tuberculosis Disease Management Pharmaceuticals tuberculosis nanotechnology diagnosis drug delivery vaccine |
| title | An Insight into Advances in Developing Nanotechnology Based Therapeutics, Drug Delivery, Diagnostics and Vaccines: Multidimensional Applications in Tuberculosis Disease Management |
| title_full | An Insight into Advances in Developing Nanotechnology Based Therapeutics, Drug Delivery, Diagnostics and Vaccines: Multidimensional Applications in Tuberculosis Disease Management |
| title_fullStr | An Insight into Advances in Developing Nanotechnology Based Therapeutics, Drug Delivery, Diagnostics and Vaccines: Multidimensional Applications in Tuberculosis Disease Management |
| title_full_unstemmed | An Insight into Advances in Developing Nanotechnology Based Therapeutics, Drug Delivery, Diagnostics and Vaccines: Multidimensional Applications in Tuberculosis Disease Management |
| title_short | An Insight into Advances in Developing Nanotechnology Based Therapeutics, Drug Delivery, Diagnostics and Vaccines: Multidimensional Applications in Tuberculosis Disease Management |
| title_sort | insight into advances in developing nanotechnology based therapeutics drug delivery diagnostics and vaccines multidimensional applications in tuberculosis disease management |
| topic | tuberculosis nanotechnology diagnosis drug delivery vaccine |
| url | https://www.mdpi.com/1424-8247/16/4/581 |
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