Maternal immunization with pneumococcal surface protein A provides the immune memories of offspring against pneumococcal infection
IntroductionStreptococcus pneumoniae (S. pneumoniae) is one of the most widespread pathogens in the world and one of the largest infectious causes of infant mortality. Although current vaccines have various benefits, antibiotic resistance and the inability to vaccinate infants less than one year old...
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1059603/full |
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| author | Masamitsu Kono Takuro Iyo Takuro Iyo Daichi Murakami Daichi Murakami Hideki Sakatani Denisa Nanushaj Muneki Hotomi |
| author_facet | Masamitsu Kono Takuro Iyo Takuro Iyo Daichi Murakami Daichi Murakami Hideki Sakatani Denisa Nanushaj Muneki Hotomi |
| author_sort | Masamitsu Kono |
| collection | DOAJ |
| description | IntroductionStreptococcus pneumoniae (S. pneumoniae) is one of the most widespread pathogens in the world and one of the largest infectious causes of infant mortality. Although current vaccines have various benefits, antibiotic resistance and the inability to vaccinate infants less than one year old demands the development of new protective strategies. One strategy, ‘maternal immunization’, is to protect infants by passive immunity from an immunized mother, although its mechanism is still not fully understood.Materials and methodsThe current study aimed to acquire immunity against S. pneumoniae in infants by maternal immunization with pneumococcal common antigen, pneumococcal surface protein A (PspA). Four-week-old female mice were immunized with recombinant PspA intranasally twice a week for three weeks. Females were mated with age-matched males after immunization, and delivered offspring.ResultsThe week-old offspring derived from and fostered by immunized mothers had more anti-PspA-specific antibody producing cells in the spleen than those derived from sham-immunized mothers. The offspring were raised up to four weeks old and were subcutaneously stimulated with recombinant PspA. The levels of anti-PspA IgG in sera after stimulation were significantly higher in the offspring derived from the immunized mothers and the induced specific antibody to PspA showed protective efficacy against systemic pneumococcal infection.DiscussionMaternal immunization is suggested to be able to provide a sustained immune memory to offspring. The current study would be a milestone in the field of maternal immunization toward a universal pneumococcal vaccine. |
| first_indexed | 2024-04-09T22:14:12Z |
| format | Article |
| id | doaj.art-98a75501a15e4a72b3370bff1ab634d5 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-09T22:14:12Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-98a75501a15e4a72b3370bff1ab634d52023-03-23T05:54:33ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882023-03-011310.3389/fcimb.2023.10596031059603Maternal immunization with pneumococcal surface protein A provides the immune memories of offspring against pneumococcal infectionMasamitsu Kono0Takuro Iyo1Takuro Iyo2Daichi Murakami3Daichi Murakami4Hideki Sakatani5Denisa Nanushaj6Muneki Hotomi7Department of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, JapanDepartment of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, JapanDepartment of Otorhinolaryngology-Head and Neck Surgery, Kinan Hospital, Tanabe, JapanDepartment of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, JapanDepartment of Otorhinolaryngology-Head and Neck Surgery, Kinan Hospital, Tanabe, JapanDepartment of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, JapanDepartment of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, JapanDepartment of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, JapanIntroductionStreptococcus pneumoniae (S. pneumoniae) is one of the most widespread pathogens in the world and one of the largest infectious causes of infant mortality. Although current vaccines have various benefits, antibiotic resistance and the inability to vaccinate infants less than one year old demands the development of new protective strategies. One strategy, ‘maternal immunization’, is to protect infants by passive immunity from an immunized mother, although its mechanism is still not fully understood.Materials and methodsThe current study aimed to acquire immunity against S. pneumoniae in infants by maternal immunization with pneumococcal common antigen, pneumococcal surface protein A (PspA). Four-week-old female mice were immunized with recombinant PspA intranasally twice a week for three weeks. Females were mated with age-matched males after immunization, and delivered offspring.ResultsThe week-old offspring derived from and fostered by immunized mothers had more anti-PspA-specific antibody producing cells in the spleen than those derived from sham-immunized mothers. The offspring were raised up to four weeks old and were subcutaneously stimulated with recombinant PspA. The levels of anti-PspA IgG in sera after stimulation were significantly higher in the offspring derived from the immunized mothers and the induced specific antibody to PspA showed protective efficacy against systemic pneumococcal infection.DiscussionMaternal immunization is suggested to be able to provide a sustained immune memory to offspring. The current study would be a milestone in the field of maternal immunization toward a universal pneumococcal vaccine.https://www.frontiersin.org/articles/10.3389/fcimb.2023.1059603/fullmaternal immunizationStreptococcus pneumoniaePspAimmunological memoryinvasive infection |
| spellingShingle | Masamitsu Kono Takuro Iyo Takuro Iyo Daichi Murakami Daichi Murakami Hideki Sakatani Denisa Nanushaj Muneki Hotomi Maternal immunization with pneumococcal surface protein A provides the immune memories of offspring against pneumococcal infection Frontiers in Cellular and Infection Microbiology maternal immunization Streptococcus pneumoniae PspA immunological memory invasive infection |
| title | Maternal immunization with pneumococcal surface protein A provides the immune memories of offspring against pneumococcal infection |
| title_full | Maternal immunization with pneumococcal surface protein A provides the immune memories of offspring against pneumococcal infection |
| title_fullStr | Maternal immunization with pneumococcal surface protein A provides the immune memories of offspring against pneumococcal infection |
| title_full_unstemmed | Maternal immunization with pneumococcal surface protein A provides the immune memories of offspring against pneumococcal infection |
| title_short | Maternal immunization with pneumococcal surface protein A provides the immune memories of offspring against pneumococcal infection |
| title_sort | maternal immunization with pneumococcal surface protein a provides the immune memories of offspring against pneumococcal infection |
| topic | maternal immunization Streptococcus pneumoniae PspA immunological memory invasive infection |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1059603/full |
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