Sex-specific parenting and depression evoked by preoptic inhibitory neurons
Summary: The role of preoptic GABAergic inhibitory neurons was addressed in parenting, anxiety and depression. Pup exposure and forced swimming resulted in similar c-Fos activation pattern in neurons expressing vesicular GABA transporter in the preoptic area with generally stronger labeling and diff...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-10-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004221010580 |
| _version_ | 1818985039042445312 |
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| author | Diána Dimén Gina Puska Vivien Szendi Eszter Sipos Dóra Zelena Árpád Dobolyi |
| author_facet | Diána Dimén Gina Puska Vivien Szendi Eszter Sipos Dóra Zelena Árpád Dobolyi |
| author_sort | Diána Dimén |
| collection | DOAJ |
| description | Summary: The role of preoptic GABAergic inhibitory neurons was addressed in parenting, anxiety and depression. Pup exposure and forced swimming resulted in similar c-Fos activation pattern in neurons expressing vesicular GABA transporter in the preoptic area with generally stronger labeling and different distributional pattern in females than in males. Chemogenetic stimulation of preoptic GABAergic cells resulted in elevated maternal motivation and caring behavior in females and mothers but aggression toward pups in males. Behavioral effects were the opposite following inhibition of preoptic GABAergic neurons suggesting their physiological relevance. In addition, increased anxiety-like and depression-like behaviors were found following chemogenetic stimulation of the same neurons in females, whereas previous pup exposure increased only anxiety-like behavior suggesting that not the pups, but overstimulation of the cells can lead to depression-like behavior. A sexually dimorphic projection pattern of preoptic GABAergic neurons was also identified, which could mediate sex-dependent parenting and associated emotional behaviors. |
| first_indexed | 2024-12-20T18:28:33Z |
| format | Article |
| id | doaj.art-98a795941e324cc19e164d211f77d587 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-20T18:28:33Z |
| publishDate | 2021-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-98a795941e324cc19e164d211f77d5872022-12-21T19:30:06ZengElsevieriScience2589-00422021-10-012410103090Sex-specific parenting and depression evoked by preoptic inhibitory neuronsDiána Dimén0Gina Puska1Vivien Szendi2Eszter Sipos3Dóra Zelena4Árpád Dobolyi5MTA-ELTE Laboratory of Molecular and Systems Neurobiology, Department of Physiology and Neurobiology, Hungarian Academy of Sciences, Eötvös Loránd Research Network, Eötvös Loránd University, 1117 Budapest, HungaryMTA-ELTE Laboratory of Molecular and Systems Neurobiology, Department of Physiology and Neurobiology, Hungarian Academy of Sciences, Eötvös Loránd Research Network, Eötvös Loránd University, 1117 Budapest, Hungary; Department of Ecology, University of Veterinary Medicine Budapest, 1078 Budapest, HungaryMTA-ELTE Laboratory of Molecular and Systems Neurobiology, Department of Physiology and Neurobiology, Hungarian Academy of Sciences, Eötvös Loránd Research Network, Eötvös Loránd University, 1117 Budapest, HungaryDepartment of Behavioral and Stress Studies, Institute of Experimental Medicine, 1080 Budapest, HungaryDepartment of Behavioral and Stress Studies, Institute of Experimental Medicine, 1080 Budapest, Hungary; Centre for Neuroscience, Szentágothai Research Centre, Institute of Physiology, Medical School, University of Pécs, 7624 Pécs, HungaryMTA-ELTE Laboratory of Molecular and Systems Neurobiology, Department of Physiology and Neurobiology, Hungarian Academy of Sciences, Eötvös Loránd Research Network, Eötvös Loránd University, 1117 Budapest, Hungary; Corresponding authorSummary: The role of preoptic GABAergic inhibitory neurons was addressed in parenting, anxiety and depression. Pup exposure and forced swimming resulted in similar c-Fos activation pattern in neurons expressing vesicular GABA transporter in the preoptic area with generally stronger labeling and different distributional pattern in females than in males. Chemogenetic stimulation of preoptic GABAergic cells resulted in elevated maternal motivation and caring behavior in females and mothers but aggression toward pups in males. Behavioral effects were the opposite following inhibition of preoptic GABAergic neurons suggesting their physiological relevance. In addition, increased anxiety-like and depression-like behaviors were found following chemogenetic stimulation of the same neurons in females, whereas previous pup exposure increased only anxiety-like behavior suggesting that not the pups, but overstimulation of the cells can lead to depression-like behavior. A sexually dimorphic projection pattern of preoptic GABAergic neurons was also identified, which could mediate sex-dependent parenting and associated emotional behaviors.http://www.sciencedirect.com/science/article/pii/S2589004221010580Behavioral neuroscienceMolecular neuroscienceBiology of gender |
| spellingShingle | Diána Dimén Gina Puska Vivien Szendi Eszter Sipos Dóra Zelena Árpád Dobolyi Sex-specific parenting and depression evoked by preoptic inhibitory neurons iScience Behavioral neuroscience Molecular neuroscience Biology of gender |
| title | Sex-specific parenting and depression evoked by preoptic inhibitory neurons |
| title_full | Sex-specific parenting and depression evoked by preoptic inhibitory neurons |
| title_fullStr | Sex-specific parenting and depression evoked by preoptic inhibitory neurons |
| title_full_unstemmed | Sex-specific parenting and depression evoked by preoptic inhibitory neurons |
| title_short | Sex-specific parenting and depression evoked by preoptic inhibitory neurons |
| title_sort | sex specific parenting and depression evoked by preoptic inhibitory neurons |
| topic | Behavioral neuroscience Molecular neuroscience Biology of gender |
| url | http://www.sciencedirect.com/science/article/pii/S2589004221010580 |
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