Assessment of corneal endothelial cell morphology and anterior segment parameters in COVID-19
Background: The ocular manifestations of the 2019 novel coronavirus disease (COVID-19) vary from acute follicular, pseudomembranous, and hemorrhagic conjunctivitis to keratoconjunctivitis with subepithelial infiltrates and dendritic lesions. Similar to other respiratory viruses, such as adenoviruses...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-05-01
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| Series: | Therapeutic Advances in Ophthalmology |
| Online Access: | https://doi.org/10.1177/25158414221096057 |
| _version_ | 1818201508883202048 |
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| author | Burak Oren Dilara Ozkoyuncu Kocabas |
| author_facet | Burak Oren Dilara Ozkoyuncu Kocabas |
| author_sort | Burak Oren |
| collection | DOAJ |
| description | Background: The ocular manifestations of the 2019 novel coronavirus disease (COVID-19) vary from acute follicular, pseudomembranous, and hemorrhagic conjunctivitis to keratoconjunctivitis with subepithelial infiltrates and dendritic lesions. Similar to other respiratory viruses, such as adenoviruses, it is thought that COVID-19 may impact the cornea. However, its impact on the cornea and anterior segment parameters are currently poorly understood. Objective: This study aims to assess the corneal endothelial cell morphology and anterior segment parameters in patients who have recovered from COVID-19. Methods: In this cross-sectional study, the COVID-19 group comprised 34 patients who had been diagnosed with and recovered from COVID-19, while the control group comprised age- and sex-matched individuals without any systemic or ocular diseases. The endothelial cell density (ECD), coefficient of variation (CV) of cell area, hexagonal cell percentage (HEX), anterior chamber depth (ACD), central corneal thickness (CCT), horizontal anterior chamber diameter (HACD), iridocorneal angle (ICA), horizontal visible iris diameter (HVID), pupillary diameter (PD), and keratometry values (K1 and K2) were analyzed for each participant. The differences in each of these between the groups were analyzed using either an independent samples t test or a Mann–Whitney U test based on the normality of the data. Results: Regarding corneal endothelial cell morphology, the ECDs for the COVID-19 and control groups were 2278.50 ± 186.78 cells/mm 2 and 2420.15 ± 222.25 cells/mm 2 , respectively ( p = 0.002). A significant increase was noted in CV values in the COVID-19 group compared with the control group ( p < 0.001). The HEX values for the COVID-19 and control groups were 56.26 ± 5.75 and 61.50 ± 3.63, respectively ( p < 0.001). Regarding the anterior segment parameters, no significant differences were observed between the groups ( p > 0.05). Conclusions: It was hypothesized that individuals who had recovered from COVID-19 would demonstrate a reduction in their endothelial functional preserves. A decrease in ECD and HEX and an increase in CV were observed in the individuals during their early post-recovery period from COVID-19. |
| first_indexed | 2024-12-12T02:54:41Z |
| format | Article |
| id | doaj.art-98a89960789444c4ad19aeb63aeebfa1 |
| institution | Directory Open Access Journal |
| issn | 2515-8414 |
| language | English |
| last_indexed | 2024-12-12T02:54:41Z |
| publishDate | 2022-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Ophthalmology |
| spelling | doaj.art-98a89960789444c4ad19aeb63aeebfa12022-12-22T00:40:48ZengSAGE PublishingTherapeutic Advances in Ophthalmology2515-84142022-05-011410.1177/25158414221096057Assessment of corneal endothelial cell morphology and anterior segment parameters in COVID-19Burak OrenDilara Ozkoyuncu KocabasBackground: The ocular manifestations of the 2019 novel coronavirus disease (COVID-19) vary from acute follicular, pseudomembranous, and hemorrhagic conjunctivitis to keratoconjunctivitis with subepithelial infiltrates and dendritic lesions. Similar to other respiratory viruses, such as adenoviruses, it is thought that COVID-19 may impact the cornea. However, its impact on the cornea and anterior segment parameters are currently poorly understood. Objective: This study aims to assess the corneal endothelial cell morphology and anterior segment parameters in patients who have recovered from COVID-19. Methods: In this cross-sectional study, the COVID-19 group comprised 34 patients who had been diagnosed with and recovered from COVID-19, while the control group comprised age- and sex-matched individuals without any systemic or ocular diseases. The endothelial cell density (ECD), coefficient of variation (CV) of cell area, hexagonal cell percentage (HEX), anterior chamber depth (ACD), central corneal thickness (CCT), horizontal anterior chamber diameter (HACD), iridocorneal angle (ICA), horizontal visible iris diameter (HVID), pupillary diameter (PD), and keratometry values (K1 and K2) were analyzed for each participant. The differences in each of these between the groups were analyzed using either an independent samples t test or a Mann–Whitney U test based on the normality of the data. Results: Regarding corneal endothelial cell morphology, the ECDs for the COVID-19 and control groups were 2278.50 ± 186.78 cells/mm 2 and 2420.15 ± 222.25 cells/mm 2 , respectively ( p = 0.002). A significant increase was noted in CV values in the COVID-19 group compared with the control group ( p < 0.001). The HEX values for the COVID-19 and control groups were 56.26 ± 5.75 and 61.50 ± 3.63, respectively ( p < 0.001). Regarding the anterior segment parameters, no significant differences were observed between the groups ( p > 0.05). Conclusions: It was hypothesized that individuals who had recovered from COVID-19 would demonstrate a reduction in their endothelial functional preserves. A decrease in ECD and HEX and an increase in CV were observed in the individuals during their early post-recovery period from COVID-19.https://doi.org/10.1177/25158414221096057 |
| spellingShingle | Burak Oren Dilara Ozkoyuncu Kocabas Assessment of corneal endothelial cell morphology and anterior segment parameters in COVID-19 Therapeutic Advances in Ophthalmology |
| title | Assessment of corneal endothelial cell morphology and anterior segment parameters in COVID-19 |
| title_full | Assessment of corneal endothelial cell morphology and anterior segment parameters in COVID-19 |
| title_fullStr | Assessment of corneal endothelial cell morphology and anterior segment parameters in COVID-19 |
| title_full_unstemmed | Assessment of corneal endothelial cell morphology and anterior segment parameters in COVID-19 |
| title_short | Assessment of corneal endothelial cell morphology and anterior segment parameters in COVID-19 |
| title_sort | assessment of corneal endothelial cell morphology and anterior segment parameters in covid 19 |
| url | https://doi.org/10.1177/25158414221096057 |
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