The effects of olive leaf extract and 28 days forced treadmill exercise on electrocardiographic parameters in rats
Background: There is evidence that regular activity can prevent of cardiovascular diseases. There are many reports that exercise and the consumption of olive leaf extract (OLE) have a positive effect on cardiovascular parameters. This study was conducted to compare the effects of exercise and OLE al...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2018-01-01
|
| Series: | Journal of Research in Medical Sciences |
| Subjects: | |
| Online Access: | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2018;volume=23;issue=1;spage=108;epage=108;aulast=Javidanpour |
| _version_ | 1811235023800500224 |
|---|---|
| author | Somayeh Javidanpour Mahin Dianat Fatemeh Ramezani Aliakbari Alireza Sarkaki |
| author_facet | Somayeh Javidanpour Mahin Dianat Fatemeh Ramezani Aliakbari Alireza Sarkaki |
| author_sort | Somayeh Javidanpour |
| collection | DOAJ |
| description | Background: There is evidence that regular activity can prevent of cardiovascular diseases. There are many reports that exercise and the consumption of olive leaf extract (OLE) have a positive effect on cardiovascular parameters. This study was conducted to compare the effects of exercise and OLE alone and together on electrocardiographic parameters in rats. Materials and Methods: Male Sprague–Dawley rats were randomly divided into six groups (n = 8 rats in each): Control, exercise, OLE (100, 200, and 400 mg/kg, orally for 14 days), and exercise + OLE (200 mg/kg of extract, orally for 14 days). Exercise training in rats was performed using treadmill for 28 days (1 h/day). Electrophysiological parameters including heart rate, PR interval, QT interval, QT corrected (QTc), RR interval, QRS voltage, and duration were obtained from lead II electrocardiogram (ECG) recorded by a PowerLab system. Statistical evaluation was done by one-way analysis of variance followed by Fisher's least significant difference test and P < 0.05 was considered statistically significant. Results: The amounts of QT (P = 0.0009) and QTc interval (P = 0.0004), RR interval (P < 0.0001), QRS duration (P = 0.004), and QRS voltage (P = 0.003) in the exercise group were significantly higher than those of the control group. However, there were no significant differences in PR interval in comparison with the control group. Exercise (P < 0.0001) and OLE (400 mg/kg, P = 0.043) alone and both in combination (P = 0.007) reduced heart rate and increased the amount of QRS voltage (P = 0.003, P = 0.047, and P = 0.046, respectively) and RR interval (P < 0.0001, P = 0.046, and P = 0.0009, respectively). Conclusion: Results of this study indicated that administration of OLE alone and in combination with exercise has negative chronotropic and positive inotropic effects and also it can prevent of prolongation of QT and QTc interval induced by severe exercise. |
| first_indexed | 2024-04-12T11:45:15Z |
| format | Article |
| id | doaj.art-98a8aba2e0f94cb6a66fe284b233b649 |
| institution | Directory Open Access Journal |
| issn | 1735-1995 1735-7136 |
| language | English |
| last_indexed | 2024-04-12T11:45:15Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Research in Medical Sciences |
| spelling | doaj.art-98a8aba2e0f94cb6a66fe284b233b6492022-12-22T03:34:24ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362018-01-0123110810810.4103/jrms.JRMS_517_18The effects of olive leaf extract and 28 days forced treadmill exercise on electrocardiographic parameters in ratsSomayeh JavidanpourMahin DianatFatemeh Ramezani AliakbariAlireza SarkakiBackground: There is evidence that regular activity can prevent of cardiovascular diseases. There are many reports that exercise and the consumption of olive leaf extract (OLE) have a positive effect on cardiovascular parameters. This study was conducted to compare the effects of exercise and OLE alone and together on electrocardiographic parameters in rats. Materials and Methods: Male Sprague–Dawley rats were randomly divided into six groups (n = 8 rats in each): Control, exercise, OLE (100, 200, and 400 mg/kg, orally for 14 days), and exercise + OLE (200 mg/kg of extract, orally for 14 days). Exercise training in rats was performed using treadmill for 28 days (1 h/day). Electrophysiological parameters including heart rate, PR interval, QT interval, QT corrected (QTc), RR interval, QRS voltage, and duration were obtained from lead II electrocardiogram (ECG) recorded by a PowerLab system. Statistical evaluation was done by one-way analysis of variance followed by Fisher's least significant difference test and P < 0.05 was considered statistically significant. Results: The amounts of QT (P = 0.0009) and QTc interval (P = 0.0004), RR interval (P < 0.0001), QRS duration (P = 0.004), and QRS voltage (P = 0.003) in the exercise group were significantly higher than those of the control group. However, there were no significant differences in PR interval in comparison with the control group. Exercise (P < 0.0001) and OLE (400 mg/kg, P = 0.043) alone and both in combination (P = 0.007) reduced heart rate and increased the amount of QRS voltage (P = 0.003, P = 0.047, and P = 0.046, respectively) and RR interval (P < 0.0001, P = 0.046, and P = 0.0009, respectively). Conclusion: Results of this study indicated that administration of OLE alone and in combination with exercise has negative chronotropic and positive inotropic effects and also it can prevent of prolongation of QT and QTc interval induced by severe exercise.http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2018;volume=23;issue=1;spage=108;epage=108;aulast=JavidanpourElectrocardiogramexerciseolive leafQRSQT interval |
| spellingShingle | Somayeh Javidanpour Mahin Dianat Fatemeh Ramezani Aliakbari Alireza Sarkaki The effects of olive leaf extract and 28 days forced treadmill exercise on electrocardiographic parameters in rats Journal of Research in Medical Sciences Electrocardiogram exercise olive leaf QRS QT interval |
| title | The effects of olive leaf extract and 28 days forced treadmill exercise on electrocardiographic parameters in rats |
| title_full | The effects of olive leaf extract and 28 days forced treadmill exercise on electrocardiographic parameters in rats |
| title_fullStr | The effects of olive leaf extract and 28 days forced treadmill exercise on electrocardiographic parameters in rats |
| title_full_unstemmed | The effects of olive leaf extract and 28 days forced treadmill exercise on electrocardiographic parameters in rats |
| title_short | The effects of olive leaf extract and 28 days forced treadmill exercise on electrocardiographic parameters in rats |
| title_sort | effects of olive leaf extract and 28 days forced treadmill exercise on electrocardiographic parameters in rats |
| topic | Electrocardiogram exercise olive leaf QRS QT interval |
| url | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2018;volume=23;issue=1;spage=108;epage=108;aulast=Javidanpour |
| work_keys_str_mv | AT somayehjavidanpour theeffectsofoliveleafextractand28daysforcedtreadmillexerciseonelectrocardiographicparametersinrats AT mahindianat theeffectsofoliveleafextractand28daysforcedtreadmillexerciseonelectrocardiographicparametersinrats AT fatemehramezanialiakbari theeffectsofoliveleafextractand28daysforcedtreadmillexerciseonelectrocardiographicparametersinrats AT alirezasarkaki theeffectsofoliveleafextractand28daysforcedtreadmillexerciseonelectrocardiographicparametersinrats AT somayehjavidanpour effectsofoliveleafextractand28daysforcedtreadmillexerciseonelectrocardiographicparametersinrats AT mahindianat effectsofoliveleafextractand28daysforcedtreadmillexerciseonelectrocardiographicparametersinrats AT fatemehramezanialiakbari effectsofoliveleafextractand28daysforcedtreadmillexerciseonelectrocardiographicparametersinrats AT alirezasarkaki effectsofoliveleafextractand28daysforcedtreadmillexerciseonelectrocardiographicparametersinrats |