The Surgical Risk Factors of Giant Intracranial Meningiomas: A Multi-Centric Retrospective Analysis of Large Case Serie
Giant intracranial meningiomas (GIMs) are a subgroup of meningiomas with huge dimensions with a maximum diameter of more than 5 cm. The mechanisms by which a meningioma can grow to be defined as a “giant” are unknown, and the biological, radiological profile and the different outcomes are poorly inv...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/12/7/817 |
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| author | Daniele Armocida Antonia Catapano Mauro Palmieri Umberto Aldo Arcidiacono Alessandro Pesce Fabio Cofano Veronica Picotti Maurizio Salvati Diego Garbossa Giancarlo D’Andrea Antonio Santoro Alessandro Frati |
| author_facet | Daniele Armocida Antonia Catapano Mauro Palmieri Umberto Aldo Arcidiacono Alessandro Pesce Fabio Cofano Veronica Picotti Maurizio Salvati Diego Garbossa Giancarlo D’Andrea Antonio Santoro Alessandro Frati |
| author_sort | Daniele Armocida |
| collection | DOAJ |
| description | Giant intracranial meningiomas (GIMs) are a subgroup of meningiomas with huge dimensions with a maximum diameter of more than 5 cm. The mechanisms by which a meningioma can grow to be defined as a “giant” are unknown, and the biological, radiological profile and the different outcomes are poorly investigated. We performed a multi-centric retrospective study of a series of surgically treated patients suffering from intracranial meningioma. All the patients were assigned on the grounds of the preoperative imaging to giant and medium/large meningioma groups with a cut-off of 5 cm. We investigated whether the presence of large diameter and peritumoral brain edema (PBE) on radiological diagnosis indicates different mortality rates, grading, characteristics, and outcomes in a multi-variate analysis. We found a higher risk of developing complications for GIMs (29.9% versus 14.8%; <i>p</i> < 0.01). The direct proportional relationship between PBE volume and tumor volume was present only in the medium/large group (Pearson correlation with <i>p</i> < 0.01) and not in the GIM group (<i>p</i> = 0.47). In conclusion, GIMs have a higher risk of developing complications in the postoperative phase than medium/large meningioma without higher risk of mortality and recurrence. |
| first_indexed | 2024-03-09T03:38:38Z |
| format | Article |
| id | doaj.art-98a927834e8d4e4aa185ce7a71e9fc8a |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T03:38:38Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-98a927834e8d4e4aa185ce7a71e9fc8a2023-12-03T14:44:41ZengMDPI AGBrain Sciences2076-34252022-06-0112781710.3390/brainsci12070817The Surgical Risk Factors of Giant Intracranial Meningiomas: A Multi-Centric Retrospective Analysis of Large Case SerieDaniele Armocida0Antonia Catapano1Mauro Palmieri2Umberto Aldo Arcidiacono3Alessandro Pesce4Fabio Cofano5Veronica Picotti6Maurizio Salvati7Diego Garbossa8Giancarlo D’Andrea9Antonio Santoro10Alessandro Frati11Neurosurgery Division, Human Neurosciences Department, “Sapienza” University, 00135 Rome, RM, ItalyNeurosurgery Division, Human Neurosciences Department, “Sapienza” University, 00135 Rome, RM, ItalyNeurosurgery Division, Human Neurosciences Department, “Sapienza” University, 00135 Rome, RM, ItalyNeurosurgery Division, Human Neurosciences Department, “Sapienza” University, 00135 Rome, RM, ItalyNeurosurgery Unit, Ospedale Santa Maria Goretti, Via Guido Reni 1, 04100 Latina, LT, ItalyNeurosurgery Unit, Department of Neuroscience “Rita Levi Montalcini”, University of Turin, Via Cherasco, 15, 10126 Torino, TO, ItalyNeurosurgery Department of Fabrizio Spaziani Hospital, Via Armando Fabi, 03100 Frosinone, FR, ItalyPoliclinico Tor Vergata, University Tor Vergata of Rome, Viale Oxford, 81, 00133 Roma, RM, ItalyNeurosurgery Unit, Department of Neuroscience “Rita Levi Montalcini”, University of Turin, Via Cherasco, 15, 10126 Torino, TO, ItalyNeurosurgery Department of Fabrizio Spaziani Hospital, Via Armando Fabi, 03100 Frosinone, FR, ItalyNeurosurgery Division, Human Neurosciences Department, “Sapienza” University, 00135 Rome, RM, ItalyIRCCS “Neuromed”, Neurosurgeon Consultant, Via Atinense, 18, 86077 Pozzilli, IS, ItalyGiant intracranial meningiomas (GIMs) are a subgroup of meningiomas with huge dimensions with a maximum diameter of more than 5 cm. The mechanisms by which a meningioma can grow to be defined as a “giant” are unknown, and the biological, radiological profile and the different outcomes are poorly investigated. We performed a multi-centric retrospective study of a series of surgically treated patients suffering from intracranial meningioma. All the patients were assigned on the grounds of the preoperative imaging to giant and medium/large meningioma groups with a cut-off of 5 cm. We investigated whether the presence of large diameter and peritumoral brain edema (PBE) on radiological diagnosis indicates different mortality rates, grading, characteristics, and outcomes in a multi-variate analysis. We found a higher risk of developing complications for GIMs (29.9% versus 14.8%; <i>p</i> < 0.01). The direct proportional relationship between PBE volume and tumor volume was present only in the medium/large group (Pearson correlation with <i>p</i> < 0.01) and not in the GIM group (<i>p</i> = 0.47). In conclusion, GIMs have a higher risk of developing complications in the postoperative phase than medium/large meningioma without higher risk of mortality and recurrence.https://www.mdpi.com/2076-3425/12/7/817meningiomabrain tumorperitumoral brain edemagiant meningiomas |
| spellingShingle | Daniele Armocida Antonia Catapano Mauro Palmieri Umberto Aldo Arcidiacono Alessandro Pesce Fabio Cofano Veronica Picotti Maurizio Salvati Diego Garbossa Giancarlo D’Andrea Antonio Santoro Alessandro Frati The Surgical Risk Factors of Giant Intracranial Meningiomas: A Multi-Centric Retrospective Analysis of Large Case Serie Brain Sciences meningioma brain tumor peritumoral brain edema giant meningiomas |
| title | The Surgical Risk Factors of Giant Intracranial Meningiomas: A Multi-Centric Retrospective Analysis of Large Case Serie |
| title_full | The Surgical Risk Factors of Giant Intracranial Meningiomas: A Multi-Centric Retrospective Analysis of Large Case Serie |
| title_fullStr | The Surgical Risk Factors of Giant Intracranial Meningiomas: A Multi-Centric Retrospective Analysis of Large Case Serie |
| title_full_unstemmed | The Surgical Risk Factors of Giant Intracranial Meningiomas: A Multi-Centric Retrospective Analysis of Large Case Serie |
| title_short | The Surgical Risk Factors of Giant Intracranial Meningiomas: A Multi-Centric Retrospective Analysis of Large Case Serie |
| title_sort | surgical risk factors of giant intracranial meningiomas a multi centric retrospective analysis of large case serie |
| topic | meningioma brain tumor peritumoral brain edema giant meningiomas |
| url | https://www.mdpi.com/2076-3425/12/7/817 |
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