South American Hemorrhagic Fevers: A summary for clinicians
Objectives: This article is one of a series on acute, severe diseases of humans caused by emerging viruses for which there are no or limited licensed medical countermeasures. We approached this summary on South American Hemorrhagic Fevers (SAHF) from a clinical perspective that focuses on pathogenes...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-04-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971221001326 |
| _version_ | 1818961207779917824 |
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| author | Maria G. Frank Adam Beitscher Camille M. Webb Vanessa Raabe Adam Beitscher Nahid Bhadelia Theodore J. Cieslak Richard T. Davey Kerry Dierberg Jared D. Evans Maria G. Frank Jonathan Grein Mark G. Kortepeter Colleen S. Kraft Chris J. Kratochvil Karen Martins Susan McLellan Aneesh K. Mehta Vanessa Raabe George Risi Lauren Sauer Erica S. Shenoy Tim Uyeki |
| author_facet | Maria G. Frank Adam Beitscher Camille M. Webb Vanessa Raabe Adam Beitscher Nahid Bhadelia Theodore J. Cieslak Richard T. Davey Kerry Dierberg Jared D. Evans Maria G. Frank Jonathan Grein Mark G. Kortepeter Colleen S. Kraft Chris J. Kratochvil Karen Martins Susan McLellan Aneesh K. Mehta Vanessa Raabe George Risi Lauren Sauer Erica S. Shenoy Tim Uyeki |
| author_sort | Maria G. Frank |
| collection | DOAJ |
| description | Objectives: This article is one of a series on acute, severe diseases of humans caused by emerging viruses for which there are no or limited licensed medical countermeasures. We approached this summary on South American Hemorrhagic Fevers (SAHF) from a clinical perspective that focuses on pathogenesis, clinical features, and diagnostics with an emphasis on therapies and vaccines that have demonstrated potential for use in an emergency situation through their evaluation in nonhuman primates (NHPs) and/or in humans. Methods: A standardized literature review was conducted on the clinical, pathological, vaccine, and treatment factors for SAHF as a group and for each individual virus/disease. Results: We identified 2 treatments and 1 vaccine platform that have demonstrated potential benefit for treating or preventing infection in humans and 4 other potential treatments currently under investigation. Conclusion: We provide succinct summaries of these countermeasures to give the busy clinician a head start in reviewing the literature if faced with a patient with South American Hemorrhagic Fever. We also provide links to other authoritative sources of information. |
| first_indexed | 2024-12-20T12:09:46Z |
| format | Article |
| id | doaj.art-98aa4d7537e34a078c6a746422d4cb0f |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-12-20T12:09:46Z |
| publishDate | 2021-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-98aa4d7537e34a078c6a746422d4cb0f2022-12-21T19:41:16ZengElsevierInternational Journal of Infectious Diseases1201-97122021-04-01105505515South American Hemorrhagic Fevers: A summary for cliniciansMaria G. Frank0Adam Beitscher1Camille M. Webb2Vanessa Raabe3Adam BeitscherNahid BhadeliaTheodore J. CieslakRichard T. DaveyKerry DierbergJared D. EvansMaria G. FrankJonathan GreinMark G. KortepeterColleen S. KraftChris J. KratochvilKaren MartinsSusan McLellanAneesh K. MehtaVanessa RaabeGeorge RisiLauren SauerErica S. ShenoyTim UyekiDenver Health and Hospital Authority, Denver, CO, United States; Corresponding author at: 194 S. Ulster St., Denver, CO, 80230, United States.Denver Health and Hospital Authority, Denver, CO, United StatesUniversity of Texas Medical Branch, Galveston, TX, United StatesNew York University Grossman School of Medicine, New York, NY, United StatesObjectives: This article is one of a series on acute, severe diseases of humans caused by emerging viruses for which there are no or limited licensed medical countermeasures. We approached this summary on South American Hemorrhagic Fevers (SAHF) from a clinical perspective that focuses on pathogenesis, clinical features, and diagnostics with an emphasis on therapies and vaccines that have demonstrated potential for use in an emergency situation through their evaluation in nonhuman primates (NHPs) and/or in humans. Methods: A standardized literature review was conducted on the clinical, pathological, vaccine, and treatment factors for SAHF as a group and for each individual virus/disease. Results: We identified 2 treatments and 1 vaccine platform that have demonstrated potential benefit for treating or preventing infection in humans and 4 other potential treatments currently under investigation. Conclusion: We provide succinct summaries of these countermeasures to give the busy clinician a head start in reviewing the literature if faced with a patient with South American Hemorrhagic Fever. We also provide links to other authoritative sources of information.http://www.sciencedirect.com/science/article/pii/S1201971221001326South American hemorrhagic feversNew World ArenavirusJunín virusArgentine hemorrhagic feverVenezuelan hemorrhagic feverMachupo virus |
| spellingShingle | Maria G. Frank Adam Beitscher Camille M. Webb Vanessa Raabe Adam Beitscher Nahid Bhadelia Theodore J. Cieslak Richard T. Davey Kerry Dierberg Jared D. Evans Maria G. Frank Jonathan Grein Mark G. Kortepeter Colleen S. Kraft Chris J. Kratochvil Karen Martins Susan McLellan Aneesh K. Mehta Vanessa Raabe George Risi Lauren Sauer Erica S. Shenoy Tim Uyeki South American Hemorrhagic Fevers: A summary for clinicians International Journal of Infectious Diseases South American hemorrhagic fevers New World Arenavirus Junín virus Argentine hemorrhagic fever Venezuelan hemorrhagic fever Machupo virus |
| title | South American Hemorrhagic Fevers: A summary for clinicians |
| title_full | South American Hemorrhagic Fevers: A summary for clinicians |
| title_fullStr | South American Hemorrhagic Fevers: A summary for clinicians |
| title_full_unstemmed | South American Hemorrhagic Fevers: A summary for clinicians |
| title_short | South American Hemorrhagic Fevers: A summary for clinicians |
| title_sort | south american hemorrhagic fevers a summary for clinicians |
| topic | South American hemorrhagic fevers New World Arenavirus Junín virus Argentine hemorrhagic fever Venezuelan hemorrhagic fever Machupo virus |
| url | http://www.sciencedirect.com/science/article/pii/S1201971221001326 |
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